Ejaculation

OTR is also expressed in male reproductive tissues, like testis, epididymis and in the prostate. OT increases the resting tone of prostatic tissue from guinea pig, rat, dog and human. The activation of these receptors could lead to the contraction of the prostate and the resulting expulsion of prostatic secretions during ejaculation. 

Dizziness, weakness, lassitude, syncope, postural or exertional hypotension, diarrhea, bradycardia, fluid retention and edema, inhibition of ejaculation, CHF Sedation, weakness, dizziness, dry mouth, constipation, impotence... 

Adverse reactions with finasteride usually are mild and do not require discontinuing use of the drug. Adverse reactions, when they occur, are related to the sexual drive and include impotence, decreased libido, and a decreased volume of ejaculate... 

Kollack-Walker S. and Newman S.W. (1997). Mating-induced expression of c-fos in the male Syrian hamster brain role of experience, pheromones, and ejaculations. Neurobiol J 32, 481-501. 

Venlafaxine was approved by the FDA recently for the treatment of PD. Venlafaxine in doses of 75 to 225 mg/day reduced panic and anticipatory anxiety in short-term controlled trials. The most common side effects include anorexia, dry mouth, constipation, somnolence, tremor, abnormal ejaculation, and sweating.52... 

Detumescence occurs with sympathetic discharge after ejaculation. Sympathetic activity induces smooth muscle contraction of arterioles and vascular spaces leading to a reduction in blood inflow, decompression of the sinusoidal spaces, and enhanced outflow. 

Onset of action is slow at around 30 minutes, which limits spontaneity. In addition, patients and partners may complain of a cold, lifeless, discolored penis that has a hinge-like feel. Painful ejaculation or inability to ejaculate are additional adverse effects. VEDs are contraindicated in persons with sickle cell disease and should be used with caution in patients on oral anticoagulants or who have bleeding disorders due to the increased possibility of priapism. 

The prostate is a heart-shaped, chestnut-sized organ that encircles the portion of the proximal urethra that is located at the base of the urinary bladder. The prostate produces secretions which are part of the ejaculate. 

Drug-induced sexual dysfunction Ejaculation disorders Decreased libido, erectile dysfunction, ejaculation disorders... 

Ejaculation disorders, including delayed and retrograde ejaculation, occur with all adrenergic antagonists and are an... 

If the patient is started on a 5a-reductase inhibitor, monitor the patient for drug-induced decreased libido, erectile dysfunction, or ejaculation disorders. If severe, discontinue the drug. 

Prostate An organ in the urogenital tract that surrounds the urethra at the base of the urinary bladder. Prostatic secretions are secreted into the urethra and become part of the ejaculate in males. 

Prostate-specific antigen (PSA) a substance secreted by the prostate and normally carried by ducts to the urethra during ejaculation PSA is used as a screening test for prostate cancer. 

Gerena, R. L et al (2000b). Immunocytochemical localization of lipocalin-type prostaglandin D synthase in the bull testis and epididymis and on ejaculated sperm. Biol. Reprod. 62, 547-56. 

Tubbs, C.E. et al. (2002) Binding of protein D/E to the surface of rat epidermal sperm before ejaculation and after deposition in the female reproductive tract./. Andrology 23(4), 512-521. 

Increased concentrations of copper in ejaculates (16 mg/kg DW vs. 2 in controls) and liver (1435 mg/kg DW vs. 63). Sperm motility in test rams was significantly decreased, abnormalities were increased, and testes copper was elevated (96-101 mg/kg DW vs. 60-69 in controls)... 

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