Prednisolone hemisuccinate

A study in 6 healthy subjects found that after taking 50-mg oral doses of glycyrrhizin every 8 hours for 4 doses, followed by a bolus injection of prednisolone hemisuccinate 96 micrograms/kg, the AUC of total prednisolone was increased by 50% and the AUC of free prednisolone was increased by 55%. This confirms the findings of two previous studies in which the glycyrrhizin was given orally, or by intravenous infusion, and one study where the route of administration is not clear. ... 

ChenM-F, ShimadaF, KatoH, Yano S, KanaokaM. Effectofglyc3frrliizinon the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. EndocrinolJpn (1990) 37, 331-41,... 

A woman stopped taking iproniazid 50 mg twice daily and about a day and a half later became restless and incoherent almost immediately after being given pethidine 100 mg for chest pain. She was comatose within 20 minutes. An hour after receiving the injection she was flushed, sweating and showed Cheyne-Stokes respiration. Her pupils were dilated and unreactive. Deep reflexes could not be initiated and plantar reflexes were extensor. Her pulse rate was 82 bpm and blood pressure 156/110 mmHg. She was reusable within 10 minutes of receiving an intravenous injection of prednisolone hemisuccinate 25 mg. A very similar reaction was described in another patient. ... 

In Older to improve the poor oral absorption of carbenicillin [4697-36-3] a bpophilic rndanyl ester has been formulated, Geocillin [33331-88-3] (5). Prednisolone [30-24-8] a steroid, is derivatized to its C-21 hemisuccinate sodium salt (6) to make it extremely water-soluble (108). 

A generic enzyme immunoassay for the determination of several synthetic corticosteroids including dexamethasone, betamethasone, flumethasone, triamcinolone, prednisolone, and methylprednisolone in milk, liver, kidney, and muscle samples was recently developed (156). Antibodies raised against dexamethasone-21-hemisuccinate-bovine serum albumin were used in this assay, whereas dexa-methasone-horseradish peroxidase was the label conjugate. Skimmed milk could be directly screened for the presence of corticosteroids at limits of detection of 0.1 ppb for dexamethasone, betamethasone, and flumethasone, 0.3 ppb for triamcinolone and 0.5 ppb for prednisolone. Tissue samples were submitted, prior to the immunoassay, to an extraction/cleanup procedure involving liquid-liquid partitions with acetonitrile-water followed by hexane-chloroform. Background values for bovine liver, swine kidney, and calf muscle were determined to be 0.26, 0.26, and 0.07 ppb, respectively, of dexamethasone equivalents. 

An asthmatic patient using inhaled budesonide and salbutamol developed an acute asthma attack. Despite emergency treatment the patient deteriorated, requiring endotracheal intubation and assisted ventilation, and there was no improvement until the glucocorticoid was withdrawn, after which there was steady improvement. Skin prick tests with prednisolone, sodium hemisuccinate, and 6-methylprednisolone-sodium hemisuccinate were positive. Thirty minutes after intradermal 6-methylprednisolone-sodium hemisuccinate 4 mg, the patient developed a dry cough, dyspnea, and wheezing and a 17% fall in FEVi. 

Yano, H., Hirayama, F., Arima, H., Uekama, K. Hydrolysis behavior of prednisolone 21-hemisuccinate/ 3-cyclodextrin amide conjugate involvement of intramolecular catalysis of amide group in drug release. Chem. Pharm. Bull. 2000, 48, 1125-1128. 

The prednisolone radioimmunoassay developed by Colburn and Buller (66) used an antiserum raised against prednisolone-21-hemisuccinate conjugated to... 

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