Precursor cells development

Ahlgren SC, Wallace H, Bishop J, Neophytou C, Raff MC 1997 Effects of thyroid hormone on embryonic oligodendrocyte precursor cell development in vivo and in vitro. Mol Cell Neurosci 9 420-432... 

Ambros V 1999 Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. Development 126 1947—1956... 

Neuronal differentiation is the process by which neuronal precursor cells develop the morphological, biochemical, and physiological properties of neurons. This is characterized by cell elongation, development of neurites, decreased... 

Jaksits S, Kriehuber E, Charbonnier AS, et al. CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner. J Immunol 1999 163(9) 4869 877. 

Broadie K.S. and Bate M. 1991. The development of adult muscles in Drosophila Ablation of identified muscle precursor cells. Development 113 103-118. 

Hematopoietic (blood) cells transport oxygen and carbon dioxide, contribute to host immunity, and facilitate blood clotting [1], A complex, interrelated, and multistep process, called hematopoiesis, controls the production as well as the development of specific marrow cells from immature precursor cells to functional mature blood cells. This well-regulated process also allows for replacement of cells lost through daily physiologic activities. The proliferation of precursor cells, the maturation of these into mature cells, and the survival of hematopoietic cells require the presence of specific growth factors. 

NFAT2 plays a key role in the development of the embryo s heart. In the precursor cells, there is a temporal and spatial specific expression of NFAT2, which directs the formation of the valves and the septum in the heart. In the adult heart, NFAT proteins also cooperate with transcription factors of the GATA and MEF2 families to regulate cardiac muscle hypertrophic responses. 

Tsai HH, Frost E, To V, et al. The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. Cell 2002 110 373-383. 

Most mammalian cell types develop from precursor cells that divide a limited number of times before they stop and terminally differentiate. In no case do we understand why the cells stop dividing when they do. The stopping mechanisms are important because they determine how many differentiated cells are produced and when differentiation begins. We have been studying the stopping mechanism in oligodendrocyte precursor cells (OPCs) isolated from the developing optic nerve of rats and mice. 

Kondo T, Raff M 2000b Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289 1754-1757 Lane ME, Sauer K, Wallace K, Jan YN, Lehner CF, Vaessin H 1996 Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87 1225-1235... 

Raff The ventralizing signals such as Sonic hedgehog that are required for motor neuron development are also required for oligodendrocyte precursors to develop from CNS stem cells, at least in the spinal cord. 

Clearly the full potential of CIS PV devices has not been fully exploited, since the combination of group I-III-VI2 elements can result in a variety of end products. Therefore, standards need to be defined that can associate device processing, fabrication, and film composition to cell band gap and efficiency. Spray CVD in conjunction with SSP design provides a proof-of-concept for a reproducible highly manufacturable process. Items that need more investigation include (1) precursor design development of more volatile/thermally... 

NT3 is also critical for glial development. There is good evidence that NT3 acts to stimulate the proliferation of oligodendrocyte precursor cells, probably in concert with platelet derived growth factor (PDGF) (see below). 

---