Polyvinylpyrrolidone Povidone-iodine

Skin disinfection." Reduction of germ counts prior to punctures or surgical procedures is desirable if the risk of wound infection is to be minimized. Useful agents include alcohols (1- and 2-propanol ethanol 60-90% iodine-re-leasing agents like polyvinylpyrrolidone [povidone, PVPj-iodine as a depot form of the active principle iodine, instead of iodine tincture), cationic surfactants, Liillmann, Color Atlas of Pharmacology <... 

The ability to form complexes with such a large number of substances is a special feature of polyvinylpyrrolidone (Section 2.2.7). The complexes formed are almost always soluble and are stable only in an acid medium. This property can be used to increase the solubility of drugs in liquid dosage forms, as in the case of povidone-iodine. In solid dosage forms, the ability to form complexes is used to increase bioavailability. A reduction in the local toxicity of certain drugs can also be achieved by complexation with povidone. A special use for the complexation properties lies in the stabilization of proteins and enzymes in diagnostics. 

Figure 96.1 The PVP-I complex. Povidone-iodine (PVP-I), a complex of the polymer polyvinylpyrrolidone and iodine, is a water-soluble powder containing 10% iodine. The available iodine content in the preparation varies from 0.05 to 1%. PVP-I solutions used for disinfection of the skin or wounds have a 1 % iodine content.

Nowadays, iodine is widely used for the manufacturing of X-ray contrast media, antimicrobial products, as tinctures of polyvinylpyrrolidone-iodine (Povidone-iodine), catalysts in chemical processes (e.g. for the production of acetic acid by carbonylation of methanol in the presence of a rhodium iodide-catalyst (Monsanto process) or an iridium iodide-catalyst (Cativa process)), and also on a smaller scale for the production of pharmaceuticals like thyroid hormones. [ 83 ]... 

X0-1-pyrrolidinyl) ethylene) iodine complex Polyvinylpyrrolidone-iodine complex Povidone-iodine... 

Hypersensitivity responses to povidone-iodine include a few clear-cut cases of anaphylaxis, generalized urticaria-angioedema, and contact dermatitis. Polyvinylpyrrolidone not iodine has been implicated as the offending component. 

Povidone-B Betadyne Polyvinylpyrrolidone/iodine Purdue, Pharma, USA Disinfectant... 

More recently available is an aqueous solution of an iodine complex of polyvinylpyrrolidone, or povidone. It does not sting when applied to open wounds. 

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