Polyvinylpyrrolidone-iodine complex

It is used in the manufacture of polyvinylpyrrolidone (PVP), in the manufacture of copolymers with, for example, aciv lic acid, acrylates, vinyl acetate and acrylonitrile and in the synthesis of phenolic resins. About 10-15% of the monomer is used in the pharmaceutical industry for the production of PVP-iodine complex used as a disinfectant. It is also used as a reactive solvent of ultraviolet-curable resins for the production of printing inks and paints as paper and textile auxiliaries, and as an additive in the cosmetics industry (Harreus, 1993). 

Kristinsson KG, Jansen B, Treitz U et al. (1991) Antimicrobial activity of polymers coated with iodine-complexed polyvinylpyrrolidone. J Biomater Appl 5 173-184... 

The ability to form complexes with such a large number of substances is a special feature of polyvinylpyrrolidone (Section 2.2.7). The complexes formed are almost always soluble and are stable only in an acid medium. This property can be used to increase the solubility of drugs in liquid dosage forms, as in the case of povidone-iodine. In solid dosage forms, the ability to form complexes is used to increase bioavailability. A reduction in the local toxicity of certain drugs can also be achieved by complexation with povidone. A special use for the complexation properties lies in the stabilization of proteins and enzymes in diagnostics. 

More recently available is an aqueous solution of an iodine complex of polyvinylpyrrolidone, or povidone. It does not sting when applied to open wounds. 

Figure 96.1 The PVP-I complex. Povidone-iodine (PVP-I), a complex of the polymer polyvinylpyrrolidone and iodine, is a water-soluble powder containing 10% iodine. The available iodine content in the preparation varies from 0.05 to 1%. PVP-I solutions used for disinfection of the skin or wounds have a 1 % iodine content.

Polyvinylpyrrolidone, crosslinked. See Polyvi nyl polypyrrol idone Crospovidone Polyvinylpyrrolidone/decene copolymer. See PVP/decene copolymer Polyvinylpyrrolidone/hexadecene copolymer. See PVP/hexadecene copolymer Polyvinylpyrrolidone-iodine complex. See PVP-iodine... 

X0-1-pyrrolidinyl) ethylene) iodine complex Polyvinylpyrrolidone-iodine complex Povidone-iodine... 

Polyvinylpyrrolidone is thus utilized as either aqueous or organic solutions in a multitude of applications. Many of these applications are also related to the chelating properties of this polymer. Thus, it forms complexes with molecular iodine (I2) and can thus be used as a reservoir of this molecule whose disinfecting properties are well known. It also gives strong interactions with natural and synthetic dyes and thus facilitates their anchoring on textile fibers by complexation with the corresponding polymers. 

---