Polyoxyl stearate

Surfactants. The use of surfactants is greatly restricted in formulating ophthalmic solutions. The order of surfactant toxicity is anionic > cationic >> nonionic. Several nonionic surfactants are used in relatively low concentrations to aid in dispersing steroids in suspensions and to achieve or to improve solution clarity. Those principally used are the sorbitan ether esters of oleic acid (Polysorbate or Tween 20 and 80), polymers of oxyethylated octyl phenol (Tyloxapol), and polyoxyl 40 stearate. The lowest concentration possible is used to perform the desired function. Their effect on preservative efficacy and their possible binding by macromolecules must be taken into account, as well as their effect on ocular irritation. The use of surfactants as cosolvents for an ophthalmic solution of chloramphenicol has been described [271]. This com-... [Pg.458]

Humectant Ammonium lactate Ammonium lactate Glyceryl stearate, polyxyl 100 stearate, polyoxyl 40 stearate, cetyl alcohol Methylparabens, propylparabens... [Pg.219]

Stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate Cetyl alcohol, diethylaminoethyl stearamide... [Pg.442]

Cetyl alcohol, glyceryl monostearate, polyoxyl 40 stearate... [Pg.442]

Cetomacrogol 1000 BP, cetostearyl alcohol Cetyl alcohol, stearyl alcohol, cetyl esters wax, polyoxyl 40 stearate, polyoxyl 8 stearate... [Pg.443]

Fatty-acids, salts and esters Aluminum monostearate, calcium stearate, ethyl oleate, isopropyl myristate, isopropyl palmitate, magnesium stearate, oleic acid, polyoxyl 40 stearate, proprionic acid, sodium stearate, stearic acid, purified stearic acid, and zinc stearate... [Pg.980]

Neomycin ThiomerosaP Mineral oil Polyoxyl 40 stearate Propylene glycol... [Pg.2480]

JP Polyoxyl 40 stearate USPNF Polyoxyl 40 stearate See also Sections 2, 3, 4, and 5. [Pg.585]

Polyoxyl 12 stearate Polyoxyl 20 stearate Polyoxyl 30 stearate Polyoxyl 40 stearate Polyoxyl 50 stearate Polyoxyl 100 stearate Polyoxyl 150 stearate Polyoxyl 4 distearate Polyoxyl 8 distearate Polyoxyl 12 distearate Polyoxyl 32 distearate Polyoxyl 150 distearate... [Pg.585]

Polyoxyethylene stearates are generally used as emulsifiers in oil-in-water-type creams and lotions. Their hydrophilicity or lipophilicity depends on the number of ethylene oxide units present the larger the number, the greater the hydrophilic properties. Polyoxyl 40 stearate has been used as an emulsifying agent in intravenous infusions. ... [Pg.586]

Polyoxyl 40 stearate Waxy solid, with a faint, bland, fat-like... [Pg.586]

Although polyoxyethylene stearates are primarily used as emulsifying agents in topical pharmaceutical formulations, certain materials, particularly polyoxyl 40 stearate, have also been used in intravenous injections and oral preparations. [Pg.587]

Chakravarty D, Each JL, Blaug SM. Study of complex formation between polyoxyl 40 stearate and some pharmaceuticals. Drug Standards 1957 25 137-140. [Pg.588]

The anhydrous petrolatum base may be made more miscible with water through the use of an anhydrous liquid lanolin derivative. Drugs can be incorporated into such a base in aqueous solution if desired. Polyoxyl 40 stearate and polyethylene glycol 300 are used in an anti-infective ointment to solubilize the active principle in the base so that the ointment can be sterilized by aseptic filtration. The cosmetic-type bases, such as the oil-in-water (o/w) emulsion bases popular in dermatology, should not be used in the eye, nor should liquid emulsions, owing to the ocular irritation produced by the soaps and surfactants, used to form the emulsion. [Pg.163]

Melt white soft paraffin, stearyl alcohol, and polyoxyl 40 stearate in the fat-melting vessel at... [Pg.122]

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