Apoptosis-inducing agents

Fig. 3. Micrograph demonstrating die effect of NaSal on morphological changes in eosinophils (W16). After eosinophils were treated for 12 h (a) without or (b) with 20 mM NaSal, which is an apoptosis-inducing agent, cells were harvested and stained with Hemacolor Rapid blood smear staining set. The stained cells were examined by light microscopy. The arrows depict the apoptotic eosinophils...

Organometallic osmium-carbonyl clusters such as [Os3(CO)10(NCCH3)2] are apoptosis-inducing agents with anticancer therapeutic potential. The mechanism appears to involve the loss of the labile acetonitrile ligand [85]. 

Kong KV, Leong WK, Ng SP, Nguyen TH, Lim LHK (2008) Osmium carbonyl clusters a new class of apoptosis inducing agents. ChemMedChem 3 1269-1275... 

Other efforts in the anticancer area have focused on the use of heterocyclic podophyllotoxin analogs 76 as antiproliferative and apoptosis inducing agents [43, 44] Libraries of analogs were prepared by a one-step multicomponent Hantzsch-type protocol employing aminopyrazoles (Scheme 18). Apoptosis... 

Apoptosis is induced by a variety of stimuli, such as genotoxic compounds, tumor necrosis factor, Eas ligand, and various environmental stresses. Despite the diversity of apoptosis-inducing agents, numerous experiments indicate that signals leading to the activation of members of the intracellular cysteine protease family, for instance, the caspase, may play a pivotal role in the initiation and execution of apoptosis induced by various stimuli. ... 

Oh et al. [188] isolated the principle (3f ,6f )-4-methyl-6-( 1 -methylethyl)-3-phenylmethylperhydro-l, 4-oxazine-2,5-dione from the fruiting bodies of Isaria japonica to study its effects as an apoptosis-inducing agent on human leukemia HL-60 cells. 

Tumor-priming Pre-treatment of solid tumor with apoptosis-inducing agents (e.g., paclitaxel) to reduce cell density and trigger cell shrinkage, so subsequent nanoparticle/macromolecule treatment can penetrate better 146... 

A -Alkylated thiazolium salts are often used to introduce complexity into the thiazole heterocycle. The synthesis of imidazothiazole-chalcone derivatives as anti-cancer and apoptosis inducing agents by Kamal et al. at the Indian Institute of Chemical Technology illustrates this point. Here, a new class of imidaza[2,l-6]thiazole chalcone derivatives were synthesized from the corresponding imidazol[2,l-6]thiazole aldehydes, which in turn... 

His group applied these reactions to the total synthesis of apoptolidinone 91, the aglycon of apoptosis-inducing agent apoptolidin A 92 (Scheme 8.15). The aldol reaction of aldehyde C6 and thiazolidinethione C3 in the presence of TiCLt (1.05 equiv), ( )-sparteine (1.0 equiv), and N-methyl-2-pyrrolidinone (1.0 equiv) afforded Evans syn ... 

Kikuchi, K., Shima, H., Mitsuhashi, S Suzuki, M and Oikawa, H. (2000) New apoptosis-inducing agents thyrsiferyl 23-acetate, tautomycin and related compounds. Drugs Future, 25, 501-507. 

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