Polyethylenimine nanoparticles

Rhaese, S., von Briesen, FI., Rubsamen-Waigmann, FI., Kreuter, J., and Langer, K. (2003), Human serum albumin-polyethylenimine nanoparticles for gene delivery, J. Controlled Release, 92(1-2), 199-208. 

Chen XA, Zhang LJ, He ZJ et al (2011) Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells. Int J Nanomedicine 6 843-853... 

Tumor-homing glycol chitosan/ polyethylenimine nanoparticles For the systemic delivery of siRNA in tumor-bearing mice [291]... 

Beyth, N., Yudovin-Farber, 1., Bahir, R., Domb, A.J., Weiss, E.I. Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans. Biomaterials 27, 3995-4002 (2006)... 

Elfinger M, Pfeifer C, Uezguen S, Golas MM, Sander B, Maucksch C, Stark H, Aneja MK, Rudolph C (2009) Self-assembly of ternary insulin-polyethylenimine (PEI)-DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells. Biomacromolecules 10 2912-2920... 

Lin J, Qiu SY, Lewis K et al. (2002) Bactericidal properties of flat surfaces and nanoparticles derivatized with alkylated polyethylenimines. Biotechnol Prog 18 1082-1086... 

Bertschinger M, Chaboche S, Jordan M, Wurm FM (2004), A spectrophotometric assay for the quantification of polyethylenimine in DNA nanoparticles, Anal. Biochem. 334 196-198. 

Langer [3] coupled 1,4-butanediol diacrylate with poly(A, A -dimethylethyl-enediamine), (III), piperazine, and 4,4 -trimethylenedipiperidine to prepare poly(p-amino esters) that were particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes were also prepared. Hubbell [4] and Zhao [5] prepared polymeric biomaterials by the nucleophilic addition of cysteine, (IV), and polyethylenimine, (V), respectively, to cx,p-unsaturated macromolecular diacrylates. 

Jia F, Shan CS, Niu L et til (2008) Ctubon ntmotube/gold nanoparticles/polyethylenimine-functionaUzed ionic liquid thin film composites for glucose biosensing. Biosens Bioelectron 24 945-950... 

In the literature, chitosan nanoparticles have been shown to neutralize the surface charge of liver cancer eells, deerease the membrane potential of mitochondria and indicate lipid peroxidation thus they eause neerotic death. Chitosan nanoparticles form either polyplexes or eneapsulate aetive molecules in their nanoparticle matrix.However, chitosan nanoparticles have lower transfection efficiency than synthetic cationic polymers sueh as polyethylenimine because of their lower endosomal escape. ... 

A series of fatty acids (FAs) were conjugated with polyethylenimine (PEI 25 kDa) (Figure 20.2). A near-infrared fluorescence probe, IR820, was used to study in vivo and ex vivo the brain targeting ability of these fatty acid-PEI conjugates (FA-PEIs). Brain uptake of FA-PEI(25 kDa)/rhodamine-6-iso-thiocyanate (RITC)-labeled DNA nanoparticles was investigated via a fluorescence imaging method. 

However, being a natural polymer, chitosan has aU disadvantages of natural materials mentioned earlier (see Section 11. A). Presently, a lot of other polyplexes based on cationic synthetic polymers have been described in the literature. Among others, we could mention rather new DNA delivery nanoparticles based on poly(2-dimethylamino)ethyl methacrylate-co-poly(ethylene glycol) (PDMAEMA) [70,71] and PEGylated polyethylenimine (PEI/DNA) [72]. The last polyplexes have been encapsulated in PLGA microparticles and proposed for mucosal (oral) polyplex-based vaccination of Wistar rats. 

Thiinemaim, A. F. and Beyermann, J. 2000. Polyethylenimine complexes with retinoic acid Structure, release profiles, and nanoparticles. Macromolecules 33 6878-85. 

He P, Greenway G, Haswell SJ (2008) The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide. Nanotechnology 19 315603-315610... 

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