Polyethylene glycol hydrogels

Observations Polyethylene glycol hydrogels are water-swollen gels. They are prepared... 

O Neal DP, Meledeo MA, Davis JR, Ibey BL, Gant VA, Pishko MV, Cote GL (2004), Oxygen sensor based on the fluorescence quenching of a ruthenium complex immobilized in a biocompatible polyethylene glycol) hydrogel, IEEE Sensors Journal 4 728 - 734. 

Leach JB, Schmidt CE. Characterization of protein release from photocros-slinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds. Biomaterials 2004 26 125-135. 

Mahoney, M. J., Anseth, K. S. Three-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogels. Biomaterials. 2006, 27,2265-2274. 

Francisco, A.T., Hwang, P.Y., Jeong, C.G., ling, L., Chen, J., Setton, L.A. Photocros-slinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration. Acta Biomater. 10(3), 1102-1111 (2014)... 

Ferretti, M., Marra, K.G., Kobayashi, K., Defail, A.J., Chu, C.R., 2006. Controlled in vivo degradation of genipin crossUnked polyethylene glycol hydrogels within osteochondral defects. Tissue Engineering 12, 2657-2663. 

Mhanna, R., Ozturk, E., Vallmajo-Martin, Q., Millan, C., Muller, M., Zenobi-Wong, M., 2014. GEOGER-modifled MMP-sensitive polyethylene glycol hydrogels induce chondrogenic differentiation of human mesenchymal stem cells. Tissue Engineering Part A 20 (7-8), 1165-1174. 

Wu J, Wei W, Wang LY, Su ZG, Ma GH (2007) A thermosensitive hydrogel based on quatemized chitosan and polyethylene glycol) for nasal drug delivery system. Biomaterials 28 2220-2232. 

Biocept introduced the 3D Hydro Array. The array is produced by mixing the oligonucleotide (or protein) into a polyethylene glycol-based prepolymer solution. The solution is then arrayed onto a glass slide (aminosilane, GAPS2 , Coming) and the droplets cured to form a hydrogel. Biocept esh-mates 10 to 10 probes per 300-p diameter spot. 

Hydrogel and water-soluble ointment achieve their consistency by means of different gel-forming agents (gelatin, methylcellulose, polyethylene glycol). Lotions are aqueous suspensions of water-insoluble and solid constituents. 

Other hydrogels are prepared from poly(a-hydroxylic) acids, e.g., lactic acid, polyacrylic acid, acrylamides and acrylated polyvinyl alcohol, and polyethylene glycol. 

A large number of researches have been carried out in order to obtain biocompatible hydrophilic surfaces by introducing water-soluble polymer grafts, including polyethylene glycol), polyacrylamide and poly(vinyl alcohol). It was, however, occasionally observed that there is an optimum in the number of grafted chains for the surface to exhibit the best biocompatibility. The discussions in Sect. 3 will present an approach to a possible elucidation of this problem. A very unique property of poly(JV-isopropylacrylamide) as thermores-ponsive hydrogel will also be discussed in this chapter. 

Hydrogel formation from four-arm polyethylene glycol methanethiosulfonate... 

Wieland JA, Houchin-Ray TL, Shea LD (2007) Non-viral vector delivery from polyethylene glycol)-hyaluronic acid hydrogels. J Control Release 120(3) 233—241... 

The above photopolymerizable adhesives can be broadly included within the glass of hydrogels even if the hydrophilic components are a material such as polyethylene glycol substituted for water. 

Sirkar K, Pishko M. Amperometric biosensors based on oxidoreductases immobilised in photopolymerised polyethylene glycol) redox polymer hydrogels. Analytical Chemistry 1998, 70, 2888-2894. 

In some cases, the rate-controlling polymeric membrane is not compact but porous. Microporous membranes can be prepared by making hydrophobic polymer membranes in the presence of water-soluble materials such as polyethylene glycol), which can be subsequently removed from the polymer matrix by dissolving in aqueous solution. Cellulose esters, loosely cross-linked hydrogels and other polymers given in Table 4.2 also give rise to porous membranes. 

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