Poly biological activity

They encapsulated poly(MA-CDA) into mannan-coated liposomes and evaluated superoxide production from mouse macrophages. The activity was three- to five-fold high compared with uncapsulated poly(MA-CDA) itself [5,11], suggesting that an increased incorporation of the polymer by the receptor-mediated endocytosis mediated the higher biological activity.. 

Esterbauer, LI. (1985). Lipid peroxidation products formation, chemical properties and biological activation. In Free Radicals in Liver Injury (eds. G. Poli, K. Cheeseman, M.U. Dianzani and T. Slater) pp. 29-47, IRL Press, Oxford. 

Poly(oxyethylene)-Si02 ormosils have been prepared as an approach to the preparation of biologically active polymer-apatite composites. For this purpose, Yamamoto et al. [72] obtained these Class II hybrids from triethoxysilyl-terminated poly(oxyethylene) (PEG) and TEOS by using the in situ sol-gel process. After being subjected to the biomimetic process to form the bone-like apatite layer, it was found that a dense apatite layer could be prepared on the hybrid materials, indicating that the silanol groups provide effective sites for CHA nucleation and growth. 

Leonetti JP, Degols G, Lebleu B (1990) Biological activity of oligonucleotide-poly(L-lysine) conjugates mechanism of cell uptake 381. Bioconjug Chem 1 149-153... 

The dissociation of 7 (Scheme 5) from poly[(G-C)] showed three relaxation times and the amplitude corresponded to the total signal, while the dissociation of 7 from poly[(A-T)] was faster and only two relaxation times, corresponding to 70% of the total signal were observed in the stopped-flow experiment. The biological activity of this class of molecules was correlated to the presence of four relaxation times when the dissociation process is measured with DNA, in particular the presence of the long-lived component of hundreds of milliseconds.86,104 105,132 143 The difference in the dissociation kinetics observed with the two polydeoxynucleotides indicates that intercalation into G-C sites is responsible for the biological activity. The dissociation of 7 from ct-DNA led to four relaxation times, a result that is in line with the relaxation times observed with poly[(G-C)] and poly[(A-T)]. 

General Comment. The foregoing examples clearly show that poly(vinyl alcohol) can be modified readily and that some of these derivatives have potential (and/or actual) biological activity. This survey is definitely not encyclopedic in scope but rather illustrative. No doubt many more examples of potentially biologically active poly(vinyl alcohol) derivatives will be developed in the future and it is entirely possible that some of these may become of value in chemotherapy and other areas where biologically active polymers are now being studied. 

Piotrovsky LB, Dumpis MA, Poznyakova LN et al. (2000) Study of the biological activity of the adducts of fullerenes with poly(N-vinylpyrrolidine). Mol Mat. 13 41-50. 

Polyamino acids are easy to prepare by nucleophUe-initiated polymerisation of amino acid JV-carboxyanhydrides. Polymers such as poly-(L)-leucine act as robust catalysts for the epoxi-dation of a wide range of electron-poor alkenes, such as y-substituted a,Ji-unsaturated ketones. The optically active epoxides so formed may be transformed into heterocyclic compounds, polyhydroxylated materials and biologically active compounds such as dUtiazem and taxol side chain. 

An anesthetic drug, Richlocaine, developed jointly by scientists from Kazakhstan and Russia, and commercially available biologically active substances bovine serum albumin, lysozyme, and catalase were used. Hydrogels of acrylamide and acrylic acid copolymer(AA-AAc),poly(N-isopropylacrylamide)(PNIPA),N-isopropylacrylamide and acrylic acid copolymer (NlPA-AAc), N-isopropylacrylamide and 2-(acrylamido)-2-propanesulfonic acid copolymer (NIPA-APSA) were synthesized. Diffusion parameters of bioactive substances into hydrogel matrices were calculated using Eq. (19.1) ... 

In earlier investigations, it had been recognized335,536 that interferon retains full biological activity after removal of sialic acid, or after removal of 50% of the total carbohydrate.532 However, its apparent hy-drophobicity, and affinity for poly(ribonucleotides), are conferred only when glycosylation is unimpaired.337... 

Katsarava et al. (4) prepared biodegradable hydrogels, (III), consisting of epoxy-containing poly(ester amides), which were used as implantable medical devices for delivery of biologically active agents. 

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