Hydrogels biodegradable

Functionalized albumin was also utilized as a degradable cross-linking agent for preparing poly(acrytic acid) (Park, 1988) and poly-W-vinylpyr-rolidone biodegradable hydrogels (Shalaby and Park, 1990). 

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Minh KN, Lee DS (2010) Injectable biodegradable hydrogels. Macromol Biosci 10 563-579... 

Park K, Shalaby WS, Park H (1993) Biodegradable hydrogels for drug delivery. Tech-nomics, Lancaster, PA... 

Elvira, C., Mano, J. F., San Roman, J., Reis, R. L. (2002). Starch-based biodegradable hydrogels with potential biomedical applications as drug delivery systems. Biomaterials, 23(9), 1955-1966. 

Katsarava et al. (4) prepared biodegradable hydrogels, (III), consisting of epoxy-containing poly(ester amides), which were used as implantable medical devices for delivery of biologically active agents. 

Biodegradable hydrogels cross-linked with hyaluronic acid serve as inflammation-sensing systems. At sites of inflammation leukocytes and macrophages produce hydroxyl radicals, which specifically break down the hyaluronic acid cross-linking, thus aiding in drug release at the site of inflammation.47 48... 

Another approach to improve the properties of chitosan hydrogels is via the preparation of polymer composites. Porous hydrogels of N-carboxymethyl chitosan/polyvinyl alcohol were prepared by Lee et al. [99]. Hydroxypropyl chitosan was combined with sodium alginate for the formation of biodegradable hydrogels [100]. Chitosan-hyaluronic acid composite was prepared by Tan et al. [101]. 

Liang Y, Liu WS et al (2011) An in situ formed biodegradable hydrogel for reconstruction of the comeal endothelium. Colloids Surf B 82 1-7... 

Kamath KR, Park K. Biodegradable hydrogels in drug delivery. Adv Drug Delivery Rev 1993 11 59-84. 

T.im DW, Choi SH, Park TG. A new class of biodegradable hydrogels stereocomplexed by enantiomeric ohgo(lactide) side chains of poly(HEMA-g-OLA)s. Macromol Rapid Comm 2000 21 464- 71. 

Bos GW, Jacobs JJL, Koten JW, Van Tomme S, Veldhuis Th, Van Nostrum CF, Den Otter W, Hennink WE. In situ cross-linked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 delivery. Eur J Pharm Sciences 2004 21 561-567. 

Thermosensitive Biodegradable Hydrogels for the Delivery of Therapeutic Agents... 

Synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid) was carried out (4). Aqueous solutions of these copolymers exhibited temperature-dependent reversible gel-sol transitions. The hydrogel can be loaded with bioactive molecules in an aqueous phase at an elevated temperature (around 45°C), where they form a solution. In this form, the polymer is injectable. On subcutaneous injection and subsequent rapid cooling to body temperature, the loaded copolymer forms a gel that can act as a sustained release matrix for drugs (4). 

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