Poly ADP-ribose

Researchers found that NAD serves as a substrate in poly(ADP-ribose) synthesis, a reaction important for DNA repair processes. In addition, it takes part in mono (ADP-ribosyl)ation reactions that are involved in endogenous regulation of many aspects of signal transduction and membrane trafficking in eukaryotic cells. [Pg.851]

Poly(ADP-ribose)polyrmerase (PARP) inhibitors, 42 (2004) 125 P2 Purinoreceptor ligands, 38 (2001) 115 p38 MAP kinase inhibitors, 38 (2001) 1 Paclitaxel, anticancer agent, 32 (1995) 289... [Pg.390]

Ame J-C et al. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 1999 274 17860-17868. [Pg.124]

The knockout of PARP-1 or PARP-2 significantly reduces the cells ability to repair damaged DNA following their exposure to radiation or cytotoxic insult [6,7]. Poly (ADP-ribose) polymer synthesis consumes substantial amounts of NAD+, and hyperactivation of PARP results in depletion of cellular NAD+ pools and energy stores, leading to cell death by necrosis. [Pg.230]

It is known that peroxynitrite is able to induce DNA strand breakage, which activates nuclear enzyme poly(ADP ribose) synthase (PARS). Szabo et al. [257] showed that the inhibition of PARS by oral treatment with lipophilic inhibitor 5-iodo-6-amino-l,2-benzopyr-one delayed the onset of arthritis in rats. It is possible that infrared pulse laser therapy can be useful for the treatment of RA patients [258]. [Pg.933]

Ataxia telangiectasia mutated (ATM), poly(ADP ribose) polymerase (PARP), DNA-dependent protein kinase, DNA replication factor C, DNA topoisomerase I, DNA fragmentation factor (DFF)45, inhibitor of caspase-activated DNAse (ICAD), lamins A, Bl, and C TRAF-1, Rafl, Ras, GAP, GDP dissociation inhibitor of Rho family GTPases, phospholipase A2, Statl... [Pg.604]

Messmer, U.K. et al., Nitric oxide induced poly(ADP-ribose) polymerase cleavage in RAW264.7 macrophage apoptosis is blocked by Bcl-2, FEES Lett., 384, 162, 1996. [Pg.181]

Zhuang, Z. X., Shen, Y., Shen, H. M., Ng, V. andOng, C. N. (1996). DNA strand breaks and poly(ADP-ribose) polymerase activation induced by crystalline nickel subsulfide in MRC-5 lung fibroblast cells, Human Exper. Toxicol., 15, 891-897. [Pg.399]

Nitrosobenzamide and 6-nitroso-l,2-benzopyrone are among the most active C-nitroso compounds that inactivate the eukariotic nuclear protein poly(ADP-ribose) polymerase at... [Pg.1023]

Pieper A.A., Vbrma A., Zhang J., Snyder S.H. Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol. Sci. [Pg.88]

Covalent links of histones HI, H2A, H2B, and H3 with poly(ADP-ribose) have been reported (for references, see Hayaishi and Ueda, 1977). Furthermore, a histone HI dimer linked by poly(ADP-ribose) has been reported. The increase in ADP-ribosylation is concomitant with cellular replication and ADP-ribosylation has been proposed as a trigger for in vivo replication in eukaryotic cells. [Pg.46]

CuvUlier, O., Rosenthal, D.S., Smulson, M.E. and Spiegel, S., 1998, Sphingosine 1-phosphate inhibits activation ofcaspases that cleave poly(ADP-ribose)polymerase and lamins during Fas- and ceramide-mediated apoptosis injurkat T lymphocytes,/. Biol. Chem. 273 2910-2916. [Pg.261]

REGULATION OF CHROMATIN STRUCTURE AND CHROMATIN-DEPENDENT TRANSCRIPTION BY POLY(ADP-RIBOSE) POLYMERASE-1... [Pg.45]

Abstract Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly... [Pg.45]

BRCT BRCAl C-terminus-like DBD DNA-binding domain dPARP Drosophila PARP MPTP l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine NAD+ Nicotinamide adenine dinucleotide NAm Nicotinamide NLS Nuclear locahzation signal OAADPR O-acetyl-ADP-ribose PAR Poly(ADP-ribose) PARG Poly(ADP-ribose) glycohydrolase PARP Poly(ADP-ribose) polymerase PARylation poly(ADP-ribosyl)ation... [Pg.45]

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