Rho family GTPases

Kaibuchi K, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem 1999 68 459-486. 

Ataxia telangiectasia mutated (ATM), poly(ADP ribose) polymerase (PARP), DNA-dependent protein kinase, DNA replication factor C, DNA topoisomerase I, DNA fragmentation factor (DFF)45, inhibitor of caspase-activated DNAse (ICAD), lamins A, Bl, and C TRAF-1, Rafl, Ras, GAP, GDP dissociation inhibitor of Rho family GTPases, phospholipase A2, Statl... 

Busch, C. and Aktories, K., Microbial toxins and the glycosylation of Rho family GTPases, Curr. Opin. Struct. Biol., 10, 528-535, 2000. 

Blum, A. E., Joseph, S. M., Przybylski, R. J., and Dubyak, G. R. (2008). Rho-family GTPases modulate Ca(2+)-dependent ATP release from astrocytes. Am. J. Physiol. Cell Physiol. 295, C231-C241. 

The Rho-family GTPase Rac was shown to localize to the plasma membrane at the pollen tube apex (Kost et al., 1999). PtdIns(4,5)P2 and PIPK are known regulators of Rho GTPases in mammalian cells. Kost et al. (1999) used pollen... 

A. W. Roberts et al. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Imimmity, 10, 183-196, 1999. 

Wrch-l/RhoU is an atypical Rho family GTPase of the Cdc42 branch (57% sequence identity to Cdc42) but with additional N- and C-terminal extensions [95]. Wrch-1 terminates in a CCFV motif, which upon first inspection appears to be a permanently prenylated CAAX motif but is not rather, it specifies reversible palmitoylation of the second cysteine... 

Berzat, A.C., Buss, J.E., Chenette, E.J., Weinbaum, C.A., Shutes, A., Der, C.J., Minden, A., and Cox, A.D. (2005). Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J Biol Chem 280 33055-33065. 

Brady, D.C., Alan, J.K., Madigan, J.P., Fanning, A.S., and Cox, A.D. (2009). The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis. Mol Cell Biol 29 1035-1049. 

Okada, S., Yamada, E., Saito, T., Ohshima, K., Hashimoto, K., Yamada, M., Uehara, Y., Tsuchiya, T., Shimizu, H., Tatei, K., Izumi, T., Yamauchi, K., et al. (2008). CDK5-dependent phosphorylation of the Rho family GTPase TClO(alpha) regulates insulin-stimulated GLUT4 translocation. J Biol Chem 283 35455-35463. 

Roberts, P.J., et al. (2008). Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem 283 25150-25163. 

TOLIAS KF, CANTLEY LC, Carpenter CL. Rho family GTPases bind to i sphoinositide kinases. JBiol ChemTlO 17656-17659,1995. 

Hill CS, Wynne J, Treisman R (1995) The Rho family GTPases RhoA, Racl, and CDC42Hs regulate transcriptional activation by SRF. In Cell 81 1159-70 Hirata K, Kikuchi A, Sasaki T et al. (1992) Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. In J. Biol. Chem. 267 8719-22... 

Hill, CS, Wynne, J and Treisman, R (1995) The rho family GTPases, rhoA, racl and cdc42Hs regulate transcriptional activation by SRF. In Cell 8 1159—70. 

The Rho family GTPase Cdc42 directly interacts wilh/l/lC /l / to control filopodia formation, actin organization, and intracellular lipid transport (Diederich et al. 2001 Tsukamoto et al. 2001). We have previously shown (Drobnik et al. 2002) that ABCAl and Cdc42 were partially localized in Lubrol- but not in Triton-X DRMs and that apoA-I preferentially depleted unesterified cholesterol/phospholipids from Lubrol DRMs, whereas HDL3 additionally decreased the cholesterol content of Triton-X DRMs. 

Figure 9-3 Structures of compounds that affect Rho-family GTPases and downstream signal transductions. Molecules in parentheses are targets of small molecules.

Price, L.S. and Collard, J.G. (2001) Regulation of the cytoskeleton by Rho-family GTPases implications for tumour cell invasion. Semin.Cancer Biol., 11, 167-173. 

Noren NK, Liu BP, Burridge K, et al. pl20 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol. 2000 150 567-580. 

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