Replication factor C

Ataxia telangiectasia mutated (ATM), poly(ADP ribose) polymerase (PARP), DNA-dependent protein kinase, DNA replication factor C, DNA topoisomerase I, DNA fragmentation factor (DFF)45, inhibitor of caspase-activated DNAse (ICAD), lamins A, Bl, and C TRAF-1, Rafl, Ras, GAP, GDP dissociation inhibitor of Rho family GTPases, phospholipase A2, Statl... 

Roles of Replication Factor C (RFC)- and Proliferating Cell Nuclear Antigen (PCNA)-like Complexes in Damage Sensing... 

Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRadl7-replication factor C complex in vitro. Proc. Natl. Acad. Sci. U.S.A. 2003 100(4) 1633-1638. 

Kenna MA Skibbens RV. Mechanical link between cohesion establishment and DNA replication Ctf7p/Ecolp, a cohesion establishment factor, associates with three different replication factor C complexes. Mol. Cell. Biol. 2003 23 2999-3007. 

Nucleotide-excision repair involves PCNA, DNA polymerase epsilon, and several accessory proteins, such as RF-C (replication factor C), RP-A (replication protein A), and Lig I (DNA ligase I). It could be that these proteins form an aggregate DNA repair machine. PCNA is a hollow circular protein that encircles DNA. PCNA binds and activates many proteins involved in DNA repair. Mismatch repair is less well characterized, but involves DNA polymerase delta. 

Examples include the focal adhesion kinase FAK (see Section 11.3), P-catenin (see Section 14.9), p21-activated kinase (PAK), replication factor C, and poly-ADP-ribose polymerase. The latter enzyme participates in the repair of DNA double-strand breaks. 

The primer is extended into daughter-strand DNA by DNA polymerase 8 (Pol 8), which is less likely to make errors during copying of the template strand than is Pol a. Pol 8 forms a complex with Rfc (replication factor C) and PCNA (proliferating cell nuclear antigen), which displaces... 

Green, C. M., Erdjument-Bromage, H., Tempst, P., Lowndes, N. F. (2000). A novel Rad24 checkpoint protein complex closely related to replication factor C. [erratum appears in Curr Biol 2000 Feb 24 10(4) R171]. Current Biology CB, 10, 39—42. 

Gruz, P., Pisani, F. M., Shimizu, M., Yamada, M., Hayashi, I., Morikawa, K., and Nohmi, T. (2001). Synthetic activity of Sso DNA polymerase Yl, an archaeal DinB-like DNA polymerase, is stimulated by processivity factors proliferating cell nuclear antigen and replication factor C.J. Biol. Chem. 276, 47394-47401. 

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