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Polar carboxylic acids

There are ill-defined limits on EI/CI usage, based mostly on these issues of volatility and thermal stability. Sometimes these limits can be extended by preparation of a suitable chemical derivative. For example, polar carboxylic acids generally give either no or only a poor yield of molecular ions, but their conversion into methyl esters affords less polar, more volatile materials that can be examined easily by EL In the absence of an alternative method of ionization, EI/CI can still be used with clever manipulation of chemical derivatization techniques. [Pg.283]

Bile acids, which exist mainly as bile salts, are polar carboxylic acid derivatives of cholesterol that are important in the digestion of food, especially the solubilization of ingested fats. The Na and salts of glycocholic acid and tauro-cholic acid are the principal bile salts (Ligure 25.41). Glycocholate and tauro-cholate are conjugates of cholic acid with glycine and taurine, respectively. [Pg.846]

An ester group can be introduced into a local anesthetic, such as tolycaine (3.26), to prevent the drug from reaching the CNS if it is injected intravascularly hy accident or abuse. The ester group is fairly stable in the tissues but is very rapidly hydrolyzed in the serum to the polar carboxylic acid, which cannot penetrate the blood-hrain barrier. [Pg.156]

RCOOH dissolves because the H of COOH can H-bond with H,0. The R portion is nonpolar and hydrophobic this effect predominates as R gets large (over five C s). Alcohols are less polar than water and are less antagonistic toward the less polar carboxylic acids of higher C content. [Pg.345]

Asymmetrization of a prochiral dicarboxylic acid diester catalyzed by lipases, where the stereo center of the product is located on the acyl side, becomes a single-step process because the polar carboxylic acid and/or amide formed are not well accepted as substrates by the Upase. One example is the enantioselective hydrolysis or ammonolysis of diethyl 3-hydroxyglutarate, as shown in Scheme 7.4, a reaction which leads to the formation of a precursor for the important chiral side chain of atorvastatin, lipitor [40, 41]. The S-enantiomer was formed with high e.e. (98%), but unfortunately this is the undesired enantiomer for the production of the pharmaceutically important product. Only a-chymotrypsin gave a predominance of the... [Pg.103]

Many oxidative processes (e.g., benzylic, allylic, alicyclic, or aliphatic hydroxylation) generate alcohol or carbinol metabolites as intermediate products. If not conjugated, these alcohol products are further oxidized to aldehydes (if primary alcohols) or to ketones (if secondary alcohols). Aldehyde metabolites resulting from oxidation of primary alcohols or from oxidative deamination of primary aliphatic amines often undergo facile oxidation to generate polar carboxylic acid derivatives." As a general rale, primary alcoholic groups and aldehyde functionalities are quite vulnera-... [Pg.99]

C), anhydride formation proceeds in the exposed area while PTBMA in the unexposed regions remains intact. After this high temperature process, the PTBMA resist film is flood-exposed and baked at <150 °C, which converts PTBMA to poly (methacrylic acid) in the initially unexposed areas. This entire process renders the unexposed area more polar (carboxylic acid) than the exposed area (anhydride), allowing negative imaging with aqueous base [121]. This concept has been later employed in the design of water-castable and water-developable resist [346]. [Pg.148]

Polar carboxylic acids Anion-exchange resins, RP (CIS and Hamilton PRP)... [Pg.334]

The results of deaminations in acetic acid were in agreement with those of Berson et al. (1964), i.e., partial retention in the exo-acetate (10.5% and 20.5% 7.109, R=C0CH3) obtained from the exo- and from the e rfo-amine, respectively, but practically full retention (98 2%) of the e rfo-acetate (7.110, R=COCH3) obtained from 7.103 and 7.104. In the less polar carboxylic acids, the authors observed increasing yields of the ewrfo-ester from the exo-amine, decreasing yields of endo-ester, and increasing enantiomeric purities of exo-alcohols and exo-esters. [Pg.284]

Verwey and de Boer surmised that the particles were surrounded by an oriented layer of oleic acid molecules. These had their polar carboxylic acid groups adsorbed at the surfaces of the particles and their nonpolar tails oriented toward the nonaqueous dispersion medium. Verwey and de Boer even represented the particles (see Fig. 2.1) by a schematic diagram that would be immediately recognizable today as depicting steric stabilization. [Pg.25]

A fatty acid consists of a long nonpolar chain of carbon atoms, with a polar carboxylic acid group at one end. Most natural fatty aeids eontain an even number of ear-bon atoms. They may be saturated, unsaturated, or polyunsaturated (containing two or more double bonds). [Pg.285]

Because of their polar hydrophilic outer shell and relatively hydrophobic cavity, cyclodextrins are able to form inclusion complexes with a wide variety of suitable hydrophobic molecules (4) eg, nonpolar hydrocarbons, polar carboxylic acid, and amine derivatives (Fig. 2, Table 2). This phenomenon leads to significant changes of the solubility and reactivity of the guest molecules without any chemical modification. Water-insoluble molecules become completely water-soluble by treatment with aqueous solution of native cyclodextrins or their derivatives, eg, methylated or hydroxypropylated cyclodextrins. [Pg.2035]

Fatty acids consist of a long, nonpolar hydrocarbon tail and a polar carboxylic acid functional group at the head. Fatty acids are the simplest lipid molecules. They have hydrophilic polar heads, but their hydrocarbon chains make them insoluble in water. Fatty acids can also be saturated or unsaturated. Saturated fatty acids have no carbon-carbon double bonds, while unsaturated fatty acids have one or more double bonds in the hydrocarbon chain. The Upid shown below is oleic acid, which is found in animal fat. [Pg.710]

Thiocillin I (158, Figure 8.8) is a member of thiopeptide antibiotics isolated from Bacillus cereus [172]. The seminal work of Walsh et al. [173] has established the significance of this 26-membered macrocycle. Recently, total synthesis of thiocillin I along with its structural assignment has been described (Scheme 8.14) [174]. The synthesis is notable for two reasons use of new methods in the retrosynthetic scheme and chemoselectivity in the macrolactonization step. The synthesis of precursor 159 involved a key step of modified Bohlmann-Rahtz pathway to the pyridine nucleus [175]. This polar carboxylic acid 159 was coupled in crude form with 162 to yield 160. Global deprotection followed by macrocyclization gave thiocillin I 158 that was identical to the natural product. The carboxyl group at... [Pg.351]

PFCAs are a subset of perfluorinated acids which consist of a non-polar perfluorinated alkyl chain and a polar carboxylic acid end group. Based upon their combination of hydrophobic and hydrophilic properties they are often used as surfactants in emulsion reactions, or as reactants to make low-molecular weight perfluorinated products. Historically the C8 PFCA (perfluorooctanoic acid—... [Pg.178]

Very polar carboxylic acids are esterified in esters before their analysis by GC-MS. In the Fisher esterification process, the reactive used is an alcohol, usually methanol or ethanol, which also has the role of solvent in the reaction. This reaction (Figure 1.4)... [Pg.3]


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See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.283 ]




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Acids polarity

Carboxylic acid derivative polarity

Carboxylic acid polarity

Carboxylic acid polarity

Polar acids

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