Podophyllum emodi Podophyllotoxin

The resin product obtained by extraction of the dried roots and rhizomes of the North American plant Podophyllum peltatum L. (the American mandrake or mayapple) and of the related Indian species Podophyllum emodi Wall. Ex Royle is known as podophyllin and has long been known to possess medicinal properties. The major active substance in podophyllin is the lignan lactone podophyllotoxin (7) although a variety of other lignans and lignan glycosides have also been isolated from podophyllin. ... 

Indian Podophyllum Podophyllum emodi WALL. Berberidaceae MD 6%-12% resin with l%-4% podophyllotoxin, only traces of peltatines, berberine ... 

Podophyllotoxin was extracted from Podophyllum emodi Wall. var. chinense Sprague. 2, 3, 4, 6- tetra- o- acetyl- P - D- ghlcopyrunose was prepared in our laboratory Pichloromethane, BF3 Et20, Trichloromethane, methanol, zinc powder, copper powder, aluminium powder, magnesium powder and tin powder were purchased from chemical store. 

Extracts of the Himalayan shrub Podophyllum emodi have been used for the treatment of malignant diseases for over two thousand years [2j. Studies by American and Swiss workers on the constituents of this plant and the May apple. Podophyllum peltatum, have shown that podophyllotoxin (LVIa) and its D-glucoside (LVIb) possess antimitotic activity. Subsequent investigations have shown that podophyllotoxin and deoxypodophyllotoxin (LVIc) are... 

Little is known about the tissue and subcellular compartmentation of lignan biosynthesis in Podophyllum. In vitro cultured cells of P. emodi are capable of synthesizing podophyllotoxin from coniferyl alcohol, implying... 

Podophyllotoxin and deoxypodophyllotoxin are the two alkaloids obtained from the Himalayan shrub Podophyllam emodi and the May Apple Podophyllum peltatum (Family Berheridaceae). 

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