Podo-phyllotoxin

A synthesis of cyclobutane derivative (301), which may be a useful substrate in an approach to podo-phyllotoxin, involves Knoevenagel reaction of an aromatic aldehyde with cyanoacetate to give (300) followed by a Michael addition, demethylcarbonylation, intramolecular alkylation and exchange of a cyano group with acetate. ... 

Podophyllum, Indian. Rhizome and roots of Podophyllum emodi Wall., Berberidaceae. Habit, Himalaya Mountains, Kashmir. Constit. 6-12% resin, 1-4% podo-phyllotoxin berbedne. 

Tenipocide VM-Z6) (SS) Derivative of podo-phyllotoxin Phase-specific (late S, early Gj) cytotoxic antitumor drug inhibits topoisomerase II used in combination therapy of leukemia and other cancers with other antitumor drugs. 

Guo YE, Chen H, Zuo S, Liu DL, Lu YL, Lv JJ, Wen SP, Zhang TC. Synthesis and antitumor activity of novel podo-phyllotoxin derivatives against multidrug-resistant cancer cells. J. Asian. Nat. Prod. Res. 2011 13(5) 417-424. 

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