Platelets headaches

More than half of the patients receiving this drug by the parenteral route experience some adverse reaction. Severe and sometimes life-threatening reactions include leukopenia (low white blood cell count), hypoglycemia (low blood sugar), thrombocytopenia (low platelet count), and hypotension (low blood pressure). Moderate or less severe reactions include changes in some laboratory tests, such as the serum creatinine and liver function tests. Other adverse reactions include anxiety, headache, hypotension, chills, nausea, and anorexia Aerosol administration may result in fatigue a metallic taste in the mouth, shortness of breath, and anorexia... 

Anagrelide -inhibitor of platelet aggregation which causes thrombocytopenia -cardiovascular effects (CHF, edema, palpitations) -anemia -nausea and vomiting -headache... 

NSAIDs may also cause kidney diseases, hepatitis, hypersensitivity reactions, rash, and CNS complaints of drowsiness, dizziness, headaches, depression, confusion, and tinnitus. All nonselective NSAIDs inhibit COX-l-dependent thromboxane production in platelets, thereby increasing bleeding risk. NSAIDs should be avoided in late pregnancy because of the risk of premature closure of the ductus arteriosus. 

Patients receiving IFN experience side effects similar to influenza symptoms headache, nausea and tiredness. IFN also decreases red blood cells, white blood cells and platelet counts. A measure of the effectiveness of IFN treatment is the marker called alanine aminotransferase in blood. The normal range is 10-70 U/L. 

Certain foods can trigger a migraine attack by effects on neurotransmitter release or metabolism in the brain. For example, a number of foods contain tryptamine which is known to cause release of other amines (dopamine, noradrenaline and 5-hydroxytryptamine) from both nerve terminals and platelets. This release could initiate the sequence of events that results in the migraine attack. Elimination of such foods from the diet can decrease the number of headaches. Compounds that discourage platelet aggregation (e.g. aspirin) may prevent such attacks. 

Clarithromycin Adverse reactions occurring in at least 3% of patients include abdominal pain, abnormal taste, diarrhea, increased BUN, nausea, and rash. Dirithromycin Adverse reactions occurring in at least 3% of patients include abdominal pain/discomfort, diarrhea/loose stools, headache, increased platelet counts, nausea, and vomiting. 

Erythromycin Adverse reactions occurring in at least 3% of patients include abdominal pain/discomfort, diarrhea/loose stools, headache, increased platelet count, and nausea. 

Chronic hepatitis B Adverse reactions occurring in at least 3% of patients include abdominal discomfort/pain arthralgia diarrhea ear, nose, and throat infections fever or chills headache malaise/fatigue myalgia nausea/vomiting rash sore throat. Lab abnormalities may include decreased platelets and elevations in ALT, CPK, and serum lipase. 

Cilostazol is a selective cAMP phosphodiesterase inhibitor. It inhibits platelet aggregation and is a direct arterial vasodilator. It is used for the symptoms of intermittent claudication in individuals with peripheral vascular disease. Side-effects of cilostazol include headache, diarrhea, increased heart rate, and palpitations. Drugs similar to cilostazol have increased the risk of death in patients with congestive heart failure. 

The main adverse effects are orthostatic hypotension and reflex tachycardia due to the rapid vasodilatation. These often result in headaches and flushes. Other side effects include gastrointestinal upsets and polyuria. Ketanserin may cause dizziness, sedation, and tiredness and may inhibit serotonin-dependent platelet aggregation. 

Serotonin is an important neurotransmitter, a local hormone in the gut, a component of the platelet clotting process, and is thought to play a role in migraine headache. Serotonin is also one of the mediators of the signs and symptoms of carcinoid syndrome, an unusual manifestation of carcinoid tumor, a neoplasm of enterochromaffin cells. In patients whose tumor is not operable, a serotonin antagonist may constitute a useful treatment. 

Recombinant human IL-11 (oprelvekin) is a polypeptide of 177 amino acids. It differs from natural IL-11 due to lack of glycosylation and the amino-terminal proline residue. Oprelvekin is administered by subcutaneous injection, usually 6-24 h after chemotherapy, at a dose of 25-50 p,g/kg per day. The drug has a half-life of about 7h. It is used to stimulate bone marrow to induce platelet production in nonmyeloid malignancies in patients undergoing chemotherapy. The common side effects of oprelvekin include fluid retention, tachycardia, edema, nausea, vomiting, diarrhea, shortness of breath and mouth sores. Other side effects include rash at the injection site, blurred vision, paresthesias, headache, fever, cough and bone pain. Rarely, CLS may occur. 

Feverfew is most often used as a prophylactic remedy for migraine headache. This action has been related to the serotonin hypothesis for migraine causation (see also Chapter 16 Histamine, Serotonin, the Ergot Alkaloids). In vitro, feverfew and parthenolide inhibit platelet aggregation and serotonin release from platelets. 

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