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Platelet-derived growth factor PDGF-BB

Mohapel, P., Frielingsdorf, H., Haggblad, J., Zachrisson, O., Brundin, P. (2005). Platelet-Derived Growth Factor (PDGF-BB) and Brain-Derived Neurotrophic Factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience, 132, 767-76. [Pg.30]

Bronchoalveolar lavage fluid from patients exposed to crocidolite in Western Australia contained mitogens for human lung fibroblasts, but platelet-derived growth factor (PDGF)-BB, tumour necrosis factor-a, insulin-like growth factor-1, or interleukin-ip did not contribute to this activity (Mut-SAERS et al. 1998). Some stimulation of proliferation was observed for the PDGF-AB antibody (P <0.05). [Pg.465]

A. General description Becaplermin, a recombinant human platelet-derived growth factor (rhPDGF-BB), is produced by recombinant DNA technology by insertion of the gene for the B chain of PDGF into the yeast Saccharomyces cerevisiae. [Pg.331]

Platelet-derived growth factors (PDGFs) exist in three different dimeric compositions, containing disulphide-linked A-, or B-, or A- and B-chains (AA, BB, or heterodimeric... [Pg.11]

Platelet derived growth factor, PDGF, types AA, AB and BB... [Pg.312]

Platelet-derived growth ikctor (PDGF-BB) hrsulin-ltke growth factor-I (IGF-I)... [Pg.95]

Trade names PDGF (Novartis) Regranex (Janssen) (Cilag AG) Indications Diabetic ulcers less than or equal to 5 cm2 Category Platelet derived growth factor-BB Half-life N/A... [Pg.62]

Figure 8.11 Platelet-derived growth factor B (PDGF-BB) detection using a proximity-dependent DNA ligation assay. [From Fredriksson et al. (2002).]... Figure 8.11 Platelet-derived growth factor B (PDGF-BB) detection using a proximity-dependent DNA ligation assay. [From Fredriksson et al. (2002).]...
The water extract of Buddieja qfficinalis (Buddlejaceae) inhibited vascular inflammation and atherosclerotic disorders. Recently, Tai et al. isolated several compounds from the flowers of the plant and tested their in vitro effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among the tested compounds, two iridoids, namely, methylscutelloside (146) and methylcatalpol (147), showed significant inhibitory effects on homodimer platelet-derived growth factor beta polypeptide (PDGF-BB)-induced proliferation in rat aortic VSMCs. Methylscutelloside (146) decreased cell proliferation at 10, 30, and 50 pM, with inhibition of 39.1%, 42.0%, and 79.6%, respectively, while methylcatalpol showed significant inhibition (80%) only at 50 pM concentration. Their inhibitory effect on rat aortic VSMC proliferation may be useful for the treatment of atherosclerosis [153]. [Pg.3051]

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See also in sourсe #XX -- [ Pg.217 ]



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Platelet-derived growth factor (PDGF

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