Platelet-derived growth factor homodimer

Insulin-like growth factor-R Colony stimulating factor 1-R Platelet-derived growth factor-R Present as a homodimer... 

Fig. 8.6 Heterodimerization of PDCF receptors, a) There are a and / subtypes of platelet derived growth factor receptor (PDCF-R) these are induced by ligand binding to form homodimers and heterodimers, b) Platelet derived growth factor (PDCF) is a dimeric growth factor, composed of chains A and/or B. The protein may exist as a homodimer (AA, BB) or heterodimer (AB). The AA homodimer of PDCF binds to the aa dimer of PDCF-R, AB binds to the aa and a 3 types, BB binds to all three combinations.

The gel contains becaplermin, a recombinant human platelet-derived growth factor for topical administration. Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet-derived growth factor into the yeast Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 kDa and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide... 

The water extract of Buddieja qfficinalis (Buddlejaceae) inhibited vascular inflammation and atherosclerotic disorders. Recently, Tai et al. isolated several compounds from the flowers of the plant and tested their in vitro effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among the tested compounds, two iridoids, namely, methylscutelloside (146) and methylcatalpol (147), showed significant inhibitory effects on homodimer platelet-derived growth factor beta polypeptide (PDGF-BB)-induced proliferation in rat aortic VSMCs. Methylscutelloside (146) decreased cell proliferation at 10, 30, and 50 pM, with inhibition of 39.1%, 42.0%, and 79.6%, respectively, while methylcatalpol showed significant inhibition (80%) only at 50 pM concentration. Their inhibitory effect on rat aortic VSMC proliferation may be useful for the treatment of atherosclerosis [153]. 

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