Plasma performance profile

Organic acid analysis could be performed in other biological specimens [14, 22] when targeting specific analyte(s) in previously diagnosed patients, or fetuses at risk for a specific condition. Plasma/serum profiling is not helpful in the laboratory evaluation of patients without a specific diagnosis, and should be avoided [2]. 

In these experimental conditions too, similar results were obtained no transmucosal passage of the tracer to the bloodstream before swallowing, as well as local persistence for hours after administration were observed. Accordingly, plasma radioactivity profile and radioactivity gel filtration profile at its peak were similar to the former set of experiments. Preliminary studies were also performed in subjects with allergic rhinitis due to P. judaica pollen, receiving radiolabelled Par j 1 intranasally. At variance with what is shown in normal individuals, the disappearance rate of radioactivity from the nasal... 

Since the IVIVC model is going to be used to predict the plasma concentrationtime profile, it is imperative to assess the predictive performance of the model via the assessement of the prediction error of the model. Depending on the intended application of the IVIVC and the therapeutic index of the drug, evaluation of the internal or external predictability may be warranted. Evaluation of internal predictability is based on the data that was used to develop the IVIVC. Evaluation of... 

General Requirements and Performance Profile of Plasma-Sprayed Bioceramic Coatings... 

For a general account on the material properties of hydroxyapatite (HAp) ceramics see Willmann (1993). Guidelines for a performance profile of plasma-sprayed bio-conductive hydroxyapatite coatings have been provided by Callahan, Gantenberg and Sands (1994) and Wintermantel and Ha (1996) (Table 6.1). A recent review paper by Demnati et al. (2014) highlights the salient physico-chemical features and the influence they have on biological consequences and in vivo performance. 

Table 6.1 Performance profile of plasma-sprayed hydroxyapatite coatings (Wintermantel and Ha, 1996 Callahan, Gantenberg and Sands, 1994).

Catalyst characterization - Characterization of mixed metal oxides was performed by atomic emission spectroscopy with inductively coupled plasma atomisation (ICP-AES) on a CE Instraments Sorptomatic 1990. NH3-TPD was nsed for the characterization of acid site distribntion. SZ (0.3 g) was heated up to 600°C using He (30 ml min ) to remove adsorbed components. Then, the sample was cooled at room temperatnre and satnrated for 2 h with 100 ml min of 8200 ppm NH3 in He as carrier gas. Snbseqnently, the system was flashed with He at a flowrate of 30 ml min for 2 h. The temperatnre was ramped np to 600°C at a rate of 10°C min. A TCD was used to measure the NH3 desorption profile. Textural properties were established from the N2 adsorption isotherm. Snrface area was calcnlated nsing the BET equation and the pore size was calcnlated nsing the BJH method. The resnlts given in Table 33.4 are in good agreement with varions literature data. 

A number of advantages exist for ion milling compared to plasma etching or RIE. Because of the collimated beam of ions, essentially vertical profiles are possible. Also, profile tapering can be achieved by tilting the substrate relative to the ion beam. In addition, ion milling is performed at pressures at least 100 times lower than those used in plasma etching or RIE. Therefore, redeposition of sputtered material is reduced. 

PK models (Section 13.2.4), PD models (Section 13.2.5), and PK/PD models (Section 13.2.6) can be used in two different ways, that is, in simulations (Section 13.2.7) and in data analysis (Section 13.2.8). Simulations can be performed if the model structure and its underlying parameter values are known. In fact, for any arbitrary dose or dosing schedule the drug concentration profile in each part of the model can be calculated. The quantitative measures of the effectiveness of drug targeting (Section 13.4) can also be evaluated. If actual measurements have been performed in in-vivo experiments in laboratory animals or man, the relevant model structure and its parameter values can be assessed by analysis of plasma disappearance curves, excretion rate profiles, tissue concentration data, and so forth (Section 13.2.8). 

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