Plasma nature

Yang H, Erdos E Second kininase in human blood plasma. Nature 1967 215 1402-1403. 

There are some other states of matter, although we don t normally encounter them. The best known is plasma. In the plasma state, the electrons have been stripped from the atoms, leaving free electrons and bare nuclei (see chapter 1 for an explanation of atoms and electrons). A plasma can be formed either by heating a gas to a very high temperature or by passing an electric current through a gas.The sun forms plasma naturally. 

Boettcher, E. W., P. Kistler, and H. Nitschmann Method of isolating the beta -metal-combining globulin from human blood plasma. Nature 181, 490 (1958). 

Szymendera J, Madajewicz S. 1968. Comparative ultrafiltrability of calcium and strontium in human plasma. Nature 217 968-969. 

Suso FA and Edwards HM Jr (1972) Binding of EDTA, histidine and acetylsalicylic acid to zinc-protein complex in intestinal content, intestinal mucosa and blood plasma. Nature 236 (5344) 230-232. 

According to the relevant power and momentum balance, Eqs. (38) and (39), the electron kinetics in steady-state plasmas is characterized by tbe conditions that at any instant the power and the momentum input from the electric field are dissipated by elastic and inelastic electron collisions into the translational and internal energy of the gas particles. This instantaneous complete compensation of the respective gain from the field and the loss in collisions usually does not occur in time-dependent plasmas, and often the collisional dissipation follows with a more or less large delay—for example, the temporally varying action of a time-dependent field. Thus, the temporal response of the electrons to certain disturbances in the initial value of their velocity distribution or to rapid changes of the electric field becomes more complicated, and the study of kinetic problems related to time-dependent plasmas naturally becomes more complex and sophisticated. Despite this extended interplay between the action of the binary electron collisions and the action of the electric field, the electron kinetics in time-... 

Addona, T.A., AbbatieUo, S.E., Schilling, B., et al. (2009) Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nature Biotechnology, 27,633-641. 

Diniz C.R., Carvalho L.F., Ryan J. and Rocha E. Silva M. "A micro metod for the determination of brady-kininogen in the blood plasma" Nature 192,1194,1961. 

In the laboratory, it has been found that similar effects can be produced if a voltage is applied between two electrodes immersed in a gas. The nature of the laboratory or instrumental discharge depends critically on the type of gas used, the gas pressure, and the magnitude of the applied voltage. The actual electrical and gas pressure conditions determine whether or not the discharge is called a corona, a plasma, or an arc. 

Other vapor introduction systems are discussed in Parts B and C (Chapters 16 and 17) because, although liquids and solids are ultimately introduced to the plasma flame as vapors, these samples are usually prepared differently from naturally gaseous ones. For example, electrothermal (oven) or laser heating of solids and liquids to form vapors is used extensively to get the samples into the plasma flame. At one extreme with very volatile liquids, no heating is necessary, but, at the other extreme, very high temperatures are needed to vaporize a sample. For convenience, the electrothermal and laser devices are discussed in Part C (Chapter 17) rather than here. 

Human blood plasma contains over 700 different proteins (qv) (1). Some of these are used in the treatment of illness and injury and form a set of pharmaceutical products that have become essential to modem medicine (Table 1). Preparation of these products is commonly referred to as blood plasma fractionation, an activity often regarded as a branch of medical technology, but which is actually a process industry engaged in the manufacture of speciaUst biopharmaceutical products derived from a natural biological feedstock (see Pharmaceuticals). 

Dielectric Film Deposition. Dielectric films are found in all VLSI circuits to provide insulation between conducting layers, as diffusion and ion implantation (qv) masks, for diffusion from doped oxides, to cap doped films to prevent outdiffusion, and for passivating devices as a measure of protection against external contamination, moisture, and scratches. Properties that define the nature and function of dielectric films are the dielectric constant, the process temperature, and specific fabrication characteristics such as step coverage, gap-filling capabihties, density stress, contamination, thickness uniformity, deposition rate, and moisture resistance (2). Several processes are used to deposit dielectric films including atmospheric pressure CVD (APCVD), low pressure CVD (LPCVD), or plasma-enhanced CVD (PECVD) (see Plasma technology). 

Alkyl mercury compounds in the blood stream are found mainly in the blood cehs, and only to a smah extent in the plasma. This is probably the result of the greater stabhity of the alkyl mercuric compounds, as well as their pecuflar solubiUty characteristics. Alkyl mercury compounds affect the central nervous system and accumulate in the brain (17,18). Elimination of alkyl mercury compounds from the body is somewhat slower than that of inorganic mercury compounds and the aryl and alkoxy mercurials. Methylmercury is eliminated from humans at a rate indicating a half-life of 50—60 d (19) inorganic mercurials leave the body according to a half-life pattern of 30—60 d (20). Elimination rates are dependent not only on the nature of the compound but also on the dosage, method of intake, and the rate of intake (21,22). 

Phospholipids. Phospholipids, components of every cell membrane, are active determinants of membrane permeabiUty. They are sources of energy, components of certain enzyme systems, and involved in Hpid transport in plasma. Because of their polar nature, phosphoUpids can act as emulsifying agents (42). The stmcture of most phosphoUpids resembles that of triglycerides except that one fatty acid radical has been replaced by a radical derived from phosphoric acid and a nitrogen base, eg, choline or serine. 

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