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PIN synthesis

Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as T-bag, SPOT, and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided. [Pg.358]

The most significant commercial product is barium titanate, BaTiO, used to produce the ceramic capacitors found in almost all electronic products. As electronic circuitry has been rniniaturized, demand has increased for capacitors that can store a high amount of charge in a relatively small volume. This demand led to the development of highly efficient multilayer ceramic capacitors. In these devices, several layers of ceramic, from 25—50 ]lni in thickness, are separated by even thinner layers of electrode metal. Each layer must be dense, free of pin-holes and flaws, and ideally consist of several uniform grains of fired ceramic. Manufacturers are trying to reduce the layer thickness to 10—12 ]lni. Conventionally prepared ceramic powders cannot meet the rigorous demands of these appHcations, therefore an emphasis has been placed on production of advanced powders by hydrothermal synthesis and other methods. [Pg.500]

The synthesis and purification of cumyl alcohol (CumOH), p-dicumyl methyl ether (DCE)) and 2-chloro-2,4,4-trimethylpentane (TMPC1), and the sources and purification of methyl chloride (MeCl), methylcyclohexane (MCHx), isobutylene have been described [9, 10]. P-Pinene (P-PIN), (Aldrich), was chromatographed over alumina (activity I, Fisher), and freshly distilled over CaH2 under nitrogen according to 1H-NMR spectroscopy and GC analysis the purity was >99%. 2,6-Di-/er/-butylpyridine (DtBP), (Aldrich), anhydrous A,A-dimethylacetamid (DMA), (Aldrich), ethylaluminum dichloride (EtAlCl2), 1.0 M solution in hexanes (Aldrich), and methanol (Fisher) were used as received. [Pg.2]

Polymerizations with the H20 /EtAlCl2 System. The Synthesis of High Molecular Weight Poly(P-PIN)... [Pg.4]

The earliest applications of the array format have been for peptide arrays. For example, the pin method for peptide synthesis involves the... [Pg.90]

When the peptide synthesis was complete, the phosphines were deprotected by sequential treatment with MeOTf and HMPT (Scheme 36.9). Addition of the rhodium precursor then created the catalyst library, which was screened, on the pin in the enantioselective hydrogenation of methyl-2-acetamidoacrylate (see Scheme 36.10). Unfortunately, this beautiful concept was poorly rewarded with rather low enantioselectivities. [Pg.1258]

This chapter will cover the efforts that have been made to use the principles of combinatorial chemistry in the development of new catalysts. In the last few years there has been a lively discussion of what is the correct definition of combinatorial chemistry. Some workers reserve the term combinatorial chemistry for the synthesis and evaluation of mixtures. For the purpose of this chapter, we will employ a liberal interpretation of the term. Since one of the definitions of the word combinatorial is, of or involving combinations (14), we will use the term to include what may be referred to as parallel synthesis. In parallel synthesis, one generates a combination of molecules, be they in separate vials or on separate pins. One view may be that a collection of vessels represents a combination of molecules. It is for this... [Pg.434]

Fig. 9.31 a) Synthesis of PS-b-polyacrylate brushes by LCSIP and consecutive ATRSIP [282]. AFM images of the tethered PS-fa-PMMA brushes with 23 nm thick PS layer and 14 nm thick PMMA layer b) after treatment with CH2CI2, c) with cyclohexane and d) after solvent exchange from CHjClj to cyclohexane, e) Cartoon proposing a model for the regular nanopattern morphology ( pinned micelles )... [Pg.422]

The stage is then set for a solid-phase synthesis. The monomer to he used in the synthesis is added to the 96 wells in the polyethylene plate. The protecting Fmoc groups are removed from the ends of the pins, and the pins themselves are inserted into the 96 wells. At this point, the monomer in each well reacts with the exposed carhoxylate group on the end of the pin, producing the monomer-support complex (comparable to that present in the first step of resin-head-hased SPS). The 96-pin plate is then removed from the 96-well plate, and the pins are washed and reinserted into a second 96-well plate that contains the second monomer to be added. The 96-pin plate is removed, washed again, and reinserted into a third 96-well plate for the addition of a third monomer. The process is repeated as often as necessary to produce the polymers to be produced in the synthesis. [Pg.146]

Obviously, graphical techniques are equally important in the study of electron momentum densities. Coulson [2,4] made the pioneering effort in this direction. Other early work was published by Henneker and Cade [305] Epstein and Lipscomb [306-308] Kaijser, Lindner, and coworkers [309-311] Tanner and Epstein [312] and Tawil and Langhoff [313,314]. A synthesis of these studies was made by Epstein and Tanner [13], who abstracted some principles that they hoped would be generally applicable to chemical bonding. One of their abstractions pinned down an observation about the anisotropy of n(p) that had been made in several of the earlier studies. Epstein and Tanner called it the bond directional principle, and they stated it as follows [13] ... [Pg.331]

For reviews of this and related reactions, see Heck Palladium Reagents in Organic Syntheses Academic Press New York. 1985, pp. 179-321 Ryabov Synthesis 198S, 233-252 Heck Org. React. 1982,27. 345-390. Adv. Catal. 1977. 26, 323-349 Volkova Levitin Vol pin Russ. Chem. Rev. 1975, 44, 552-560 Moritani Fujiwara Synthesis 1973, 524-533 Jira Freieslcben Organomet. React. 1972,3, 1-190, pp. 84-105. [Pg.717]

Giger, R. Pin Sort-and-Combine Method for HTP Synthesis of Individual Crowns, paper presented at the Cambridge Healthtec Institue Conference, Barcelona, Spain, 1997. [Pg.217]

In addition to incorporating the 4-(2-aminoethyl)dibenzofuran-6-propanoic acid template into small peptides where a reverse turn is desired, we have also recently incorporated this template into a mini-protein called the PIN WW domain. WW domains have a three-stranded antiparallel p-sheet structure that mediates intracellular protein-protein interactions. 31 Substitution of this 3-turn mimetic into loop 1 of the PIN WW domain leads to a folded, three-stranded, antiparallel p-sheet structure with a stability indistinguishable from that of the all a-amino acid sequence. The template-incorporated PIN WW domain (11) was synthesized by an Fmoc-based solid-phase peptide synthesis strategy (Scheme 8), utilizing N-Fmoc-protected 4-(2-aminoethyl)dibenzofuran-6-propanoic acid 10. 11 The synthesis of 10, similar to that of 8, has been published.1 1 ... [Pg.800]

Supports of different macroscopic shape have been used for solid-phase synthesis. The most common are spherical particles (beads, 0.04-0.15 mm), which are readily weighed, filtered, and dried, and are well-suited for most applications. Other forms of insoluble support include sheets [1], crown-shaped pins [2], or small discs [3]. [Pg.18]

Linear polystyrene can be generated on insoluble polymers by /-irradiation of the latter in a solution of styrene [110]. Polystyrene grafted onto polytetrafluoroethylene [111-116], polyethylene [2,110,117], or polypropylene [15] can be functionalized in the same way as cross-linked polystyrene, and loadings of up to 1.0 mmol/g can be attained. These supports, which are also available as crown-shaped pins (Multipin, 2-3 mm diameter, 8-10 pmol per crown), have been used for the synthesis of peptides [2,110,111,118], oligonucleotides [112-115,117,119], and small molecules [120-122]. [Pg.25]

Benzodiazepines were the first class of heterocyclic compounds to be synthesized on the SynPhase surface. In 1994, Ellman and co-workers24 reported a 192 member library of structurally diverse 1,4-benzodiazepines. These compounds were prepared on Mimotopes pins that were grafted with polyacrylic acid, the surface originally used for antibody epitope elucidation.10 Ellman and co-workers25 subsequently synthesized a 1680-member 1,4-benzodiazepine library on SynPhase Crowns that were grafted with a methacrylic acid/dimethylacrylamide copolymer, one of the first SynPhase surfaces designed for solid-phase synthesis. The synthesis was performed on a preformed linker-template system in order to avoid low aminobenzophenone incorporation in this case the HMP acid-labile linker... [Pg.43]

Scheme 12.20. Synthesis of (5R,6S)-6-acetoxy-5-hexadecanolide using a three-component hetero[4+2] cycloaddition/ allylboration, by Gao and Hall [63]. Ac = acetyl, pin = pinacolato, Ms = methanesulfonyl, mCPBA = m-chloroperoxybenzoic acid. Scheme 12.20. Synthesis of (5R,6S)-6-acetoxy-5-hexadecanolide using a three-component hetero[4+2] cycloaddition/ allylboration, by Gao and Hall [63]. Ac = acetyl, pin = pinacolato, Ms = methanesulfonyl, mCPBA = m-chloroperoxybenzoic acid.
Scheme 12.27. Synthesis of methyl dihydropalustramate using a three-component aza[4+2] cycloaddition/allylboration, by Toure and Hall [91] Bn = benzyl, pin = pinacolato. Scheme 12.27. Synthesis of methyl dihydropalustramate using a three-component aza[4+2] cycloaddition/allylboration, by Toure and Hall [91] Bn = benzyl, pin = pinacolato.

See other pages where PIN synthesis is mentioned: [Pg.132]    [Pg.169]    [Pg.303]    [Pg.132]    [Pg.169]    [Pg.303]    [Pg.279]    [Pg.6]    [Pg.149]    [Pg.134]    [Pg.91]    [Pg.292]    [Pg.64]    [Pg.110]    [Pg.88]    [Pg.209]    [Pg.26]    [Pg.176]    [Pg.145]    [Pg.165]    [Pg.113]    [Pg.70]    [Pg.89]    [Pg.1]    [Pg.258]    [Pg.801]    [Pg.97]    [Pg.79]    [Pg.289]    [Pg.497]    [Pg.513]    [Pg.50]   
See also in sourсe #XX -- [ Pg.161 ]




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