Physiological functions neutrophils, activated

The role of CaMKIy in neurite growth is one of the few physiologically important roles attributed to the CaMKI isoforms. Besides possible roles in cell cycle for CaMKIa and neutrophil activation for CaMKlS (see below), the functions of the other isoforms of CaMKI remain to be determined. Based on the involvement of CaMKIy in neurite growth, it would be interesting to learn whether growth and... 

On the other hand, there are a number of human diseases associated with an overactivity of neutrophil function. Many facets of the neutrophil antimicrobial arsenal, such as reactive oxygen metabolites and proteases, can attack host tissues as effectively as they can attack microbial targets. For this reason, activation of neutrophils under physiological conditions is carefully regulated and damage restricted for the following reasons ... 

One of the main reasons for interest in chemokines is the ease with which their expression can be documented in physiological settings involving leukocyte trafficking or in diseases characterized by inflammatory cell infiltration. In the case of most ELR-containing CXC chemokines, their ability to attract neutrophils in vitro is paralleled by a similar activity when injected in vivo (1-3). However, in the case of non-ELR CXC and most CC chemokines, injection in vivo has resulted in disparate and inconsistent reports of activity (4-6). Thus, in order to be able to infer anything about the function of chemokines in normal physiology or disease, it must be demonstrated that their in vitro activities accurately predict their in vivo activities. 

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