Pharmacological and Physiological Properties

Unlike their 1,3,4-isomers, 5-sulfanilamido-1,2,4-thiadiazoles containing branched-chain 3-substituents have no blood-sugar-reducing 

Fungicidal properties are exhibited by 3-methyl-209 and 3-methyl-thio-5-arylsulfonyl-l,2,4-thiadiazoles,210 5-substituted 3-trichloro-methyl-1,2,4-thiadiazoles,97 2,4-dimethyl-3-thiono-l,2,4-thiadiazoli-din-5-one,164,166,211 and 2,4-dimethyl-l,2,4-thiadiazolidine-3,5-dithi-one.165,166 5-Halogeno-3-halogenoalkyl-l,2,4-thiadiazoles are active against Rhizoctonia aolani,9B 

The fungicidal properties212 and production of albinism in plants213 that have been referred to in connection with two 1,2,4-thiadiazoles are actually properties of the corresponding 1,3,4-isomers.214 

Simon and 1.1. Kovtunovskaya-Levshina, Tiolovye Soedinen. v Med., Ukrain. Nauch.-Issledovatel. Sanit.-Khim. Inst., Trudy Nauch. Konf., Kiev 40 (1957) (pub. 1959) Chem. Abetr. 54, 24760 (1960). 

The radioprotective action of 3,5-diamino-l,2,4-thiadiazole, its 3-toluene-p-sulfonyl derivative, and the corresponding 5-methyl-amino- and 5-anilino analogs has been determined.218 Administration of the parent compound results in 69% survival in mice after 900 r whole body X-radiation, a result that compares favorably with the effects of such established protectors as AET ( S-2-aminoethyl-thiuronium bromide hydrobromide) and cysteamine.218 

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Daval, J-L, Nehlig A, and Nicolas F. Physiological and pharmacological properties of adenosine Therapeutic implications. Life Sci 1991 49 1435-1453. 

The physiological and pharmacological properties of the new compounds described in this review have not yet been investigated. Thus, nothing can be said concerning potential applications. 

Clearly, elucidation of the properties of native Ca2+ currents in schistosomes and other flatworms has presented major challenges. A molecular approach offers an alternative for studying the physiological and pharmacological properties of cloned Ca2+ channel subunits expressed in heterologous systems. Ultimately, however, the characterization of native currents within schistosome cells will be essential for understanding the properties of these channels and the physiological roles they play within the parasite. 

Blair, K.L. and Anderson, P.A.V. (1994) Physiological and pharmacological properties of muscle cells isolated from the flatworm Bdelloura Candida (triclada). Parasitology 109, 325-335. 

The majority of insect neuropeptides discovered thus far seem to have the property of regulating the contractile activity of either skeletal and/or visceral muscles. Whether these are the principal or auxiliary modes of action for a given peptide must await a more comprehensive assessment of their individual profiles of activity in a variety of physiological systems. What follows is a summary of our current understanding of the physiological and pharmacological properties of the insect neuropeptides that regulate muscle activity. 

Jandhyala BS, Horn GJ. 1983. Minireview Physiological and pharmacological properties of vanadium. Life Sci 33 1325-1340. 

Different evidence supports the possible existence of functional interactions between cannabinoids and other drugs of abuse including opioids, psychostimulants, ethanol and nicotine. Findings in support of a link between cannabinoids and other drugs of abuse include (1) the existence of common physiological and pharmacological properties (opioids, ethanol, nicotine) (2) the stimulation of dopamine release after their administration (psychostimulants, opioids, ethanol, nicotine) ... 

Physiological and Pharmacological Properties Biologically Active Acetylenic Compounds Acetylenes as Phytoalexins Plant-Insect and Plant-Nematode Relationships Phototoxic Effects of Acetylenic Compounds Allenic Fatty Acids References... 

The physiological and pharmacological properties of serotonin have been the subjects of recent reidews S6S, S 4)-... 

The purpose of the present chapter is to provide an overview of these distinct and complementary roles of the arachidonate cascade, intracellular and transcellular. We will first consider a series of messenger functions that arachidonate metabolites may serve within cells. We will turn next to the transport mechanisms used by the eicosanoids to exit cells and to gain access to transmembrane receptors present on the surface of cells nearby. Finally, we will briefly discuss the molecular structures of the eicosanoid receptors, their transduction mechanisms and some of their physiological and pharmacological properties. 

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