Hydrogels, cytocompatible

Kretsinger JK, Haines LA, Ozbas B et al (2005) Cytocompatibility of self-assembled ss-hairpin peptide hydrogel surfaces. Biomaterials 26 5177-5186... 

Kang HS, Park SH, Lee YG et al (2007) Polyelectrolyte complex hydrogel composed of chitosan and poly(y-glutamic acid) for biological application Preparation, physical properties, and cytocompatibility. J Appl Polym Sci 103 386-394... 

Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions... 

Keywords Cell encapsulation Cell engineering Cytocompatibility Hydrogel Phospholipid polymers... 

Cytocompatible Polymer Hydrogels Composed of Water-Soluble Phospholipid Polymers... 

Similarly to the phospholipid polymers, the MPC polymers show excellent biocompatibility and blood compatibility [43—48]. These properties are based on the bioinert character of the MPC polymers, i.e., inhibition of specific interaction with biomolecules [49, 50]. Recently, the MPC polymers have been applied to various medical and pharmaceutical applications [44-47, 51-55]. The crosslinked MPC polymers provide good hydrogels and they have been used in the manufacture of soft contact lenses. We have applied the MPC polymer hydrogel as a cell-encapsulation matrix due to its excellent cytocompatibility. At the same time, to prepare a spontaneously forming reversible hydrogel, we focused on the reversible covalent bonding formed between phenylboronic acid and polyol in an aqueous system. 

Fig. 2 Concept of 3D cell engineering based on a spontaneously forming and reversible PMBV/ PVA hydrogel with high cytocompatibility as soft biodevice...

In consideration of the clinical importance of being able to visualize any implant material within the body, radio-opaque hydrogels for NPR have been formulated [69]. Copolymers of iodobenzoyl-oxo-ethyl methacrylate (4IEMA) and hydrophilic PVP or hydroxylethyl methacrylate (HEMA) exhibit appropriate swelling characteristics, viscoelastic mechanical properties, and excellent cytocompatibility [69]. Moreover, inclusion of the covalently attached iodine molecules allowed for hydrogel visualization via X-ray in a porcine cadaveric spine model [69],... 

Qi B, Yu A et al (2010) The preparation and cytocompatibility of injectable thermosensitive chltosan/poly(vlnyl alcohol) hydrogel. J Huazhong Univ Sci Technolog Med Scl 30 89-93... 

Glycidyl methacrylate derivatized dextran and/or HA were cross-linked into hydrogels in the presence of photoinitiators and UV radiation in multi-well inserts. The materials showed good cytocompatibility in vitro using smooth muscle cell migration/proliferation assay (84). 

The hydrogels were able to prevent drug leakage to a common conservation liquid for SCLs and to sustain drug delivery in lacrimal fluid for 2 weeks. The hydrogels with pendant pCDs are particularly useful for the development of cytocompatible medicated implants or biomedical devices, such as drug-loaded SCLs. 

Ichikawa, H., Peppas, N.A. Novel complexation hydrogels for oral peptide delivery In vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using caco-2 cell monolayers. J. Biomed. Mater. Res., 67, 609, 2003. 

Williams, C. G, Malik, A. N, Kim, T. K, Manson, P. N. Elisseeff, J. H. (2005) Variable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulation. Biomaterials, 26, 1211-1218. 

Mansur HS, Costa ES Jr, Mansur AAP, Barbosa-Stancioli EE (2009) Cytocompatibility evaluation in cell-culture systems of chemically crosslinked chitosan/PVA hydrogels. Mat Sci Eng C 29 1574-1583... 

Vo TN, Ekenseair AK, Kasper FK, Mikos AG. Synthesis, physicochemical characterization, and cytocompatibility of bioresorbable, dual-geUing injectable hydrogels. 

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