Phosphoinositol-3-kinase

Phosphoinositol kinases Phosphatidylinositol kinases Phosphatidylinositide kinases... 

Mediator Receptor-hormone complex cAMP,cGMP,Ca k metabolites of complex phosphoinositols, kinase cascades... 

Yotsushima, K. Mitsui, T. Hayakawa, T. Purification of phosphoinositol kinase from suspension-cultured cells of rice (Oryza sativa L.). Biosci. Biotech-nol. Biochem., 59, 1953-1955 (1995)... 

Majumder, A.L., Mandal N.C., and Biswas, B.B., 1972, Phosphoinositol kinase from germinating mung bean seeds. Phytochemistry 11 503-508. 

Non-receptor serine/threonine kinases and dual specificity kinases cAMP-dependent protein kinase (PKA) Phosphoinositol-3-kinase (PI-3K) Cyclin-dependent kinase (CDK) Mitogen-activated protein kinase (MAPK) MAPKK (ERK)... 

The major current working hypothesis for lithium s therapeutic mechanism of action supposes that its effects on phosphoinositol turnover, leading to an early relative reduction of myoinositol in human brain, are part of an initiating cascade of intracellular changes. Effects on specific isoforms of protein kinase C may be most relevant. Alterations of protein kinase C-mediated signaling alter gene expression and the production of proteins implicated in... 

Miyakawa, Y. Rojnuckarin, P. Habib, T. Kaushansky, K. Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. J. Biol. Chem., 276, 2494-2502 (2001)... 

When IL-2 binds to high-affinity receptors, it becomes internalized following receptor-mediated endocytosis. After high-affinity binding, there is an increase in the stimulation of phosphoinositol turnover, redistribution of protein kinase C from the cytoplasm to the cell membrane, and an increased expression of IL-2 receptors, with low-affinity receptors being preferentially increased. 

Very recent efforts to further evaluate the functional implications of phosphoinositol signaling in vertebrate chemosensory transduction have led to the discovery that not only the phosphoinositol breakdown pathway catalyzed by phospholipase C, but also membrane phosphoinositols themselves involving phosphoinositide-3-kinase may play a functional role in the transduction process. It was found that 3-phosphoinositides signaling in concert with the canonical phosphoinositide turnover pathway modulate the cyclic nucleotide signaling cascade downstream of the receptor. The data suggest that 3-phosphoinositide, the primary product of PI3K activity, attenuates the cyclic nucleotide-dependent excitation of olfactory neurons (Spehr et al., 2002). 

CD7 transmembrane protein linked to PI-3 (phosphoinositol-3) kinase cellular function not thoroughly clarified... 

Phospholipase C A family of intracellular enzymes central to many signal transduction pathways via effects on Ca + and protein kinase C. Phospholipase C catalyzes the hydrolysis of phosphoinositol 4,5-bisphosphate to yield 1,4,5-inositol triphosphate and diacylglycerol. See Irvine, R.F., The enzymology of stimulated inositol lipid turnover. Cell Calcium 3, 295-309,1982 Farese, R.V., Phospholipids as intermediates in hormone action. Mol. Cell Endocrinol. 35,1-14,1984 Majerus, P.W., The production... 

Carvalho CR, Carvalheira JB, Lima MH, et al. Novel signal transduction pathways for luteinizing hormone and interaction with insulin activation of Janus kinase/ signal transducer and activator of transcription and phosphoinositol 3 kinase/Akt pathways. Endocrinology 2003 144 638-647. 

---