Phosphatidylserine receptor

Fadok, V.A., Warner, M.L., Bratton, D.L. and Henson, P.M., 1998, CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (avp3)l, 7. Immunol. 161 6250-6257. 

Tail, J.F., and Smith, C., 1999, Phosphatidylserine receptor Role of CD36 in binding of anionic phospholipid vesicles to monocytic cells, J. Biol. Chem. 274 3048-3054. 

Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA, et al. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol 1992 149 4029-4035. 

Li MO, Sarkisian MR, Mehal WZ, RaMc P, Flavell RA (2003) Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 302 1560-1563... 

Part of this response may also be related to the ability of neutrophil elastase to degrade and/or remove a number of receptors involved in the uptake of bacteria and/or in the responses to cytokines and other molecules (121-123). In addition, as will be discussed in the next section, neutrophil elastase also reduces the level of expression of the phosphatidylserine receptor by macrophages, a receptor that is involved in the uptake of apoptotic neutrophils. 

Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002 109 661. 

Bandyopadhyay and Bong have presented a new synthetic approach to trifunctional phosphatidyl serine lipid mimics (46) for identification of a novel phosphatidylserine receptor of proteins. It contained a lipid head-group for a recognition, a benzophenone moiety for photoaffinity cross-linking, and an alkyne for post-labeling readout. ... 

Minami M, Kume N, Shimaoka T, et al. Expression of scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX) in human atheroma. Ann N Y Acad Sci 2001 947 373-376. 

FIGURE 1 2-2 Schematic diagram of the phosphorylation sites on each of the four 60kDa subunits of tyrosine hydroxylase (TOHase). Serine residues at the N-terminus of each of the four subunits of TOHase can be phosphorylated by at least five protein kinases. (J), Calcium/calmodulin-dependent protein kinase II (CaM KII) phosphorylates serine residue 19 and to a lesser extent serine 40. (2), cAMP-dependent protein kinase (PKA) phosphorylates serine residue 40. (3), Calcium/phosphatidylserine-activated protein kinase (PKC) phosphorylates serine 40. (4), Extracellular receptor-activated protein kinase (ERK) phosphorylates serine 31. (5), A cdc-like protein kinase phosphorylates serine 8. Phosphorylation on either serine 19 or 40 increases the activity of TOHase. Serine 19 phosphorylation requires the presence of an activator protein , also known as 14-3-3 protein, for the expression of increased activity. Phosphorylation of serines 8 and 31 has little effect on catalytic activity. The model shown includes the activation of ERK by an ERK kinase. The ERK kinase is activated by phosphorylation by PKC. (With permission from reference [72].)... 

Massicotte,G., 1996, Effect of phosphatidylserine on the binding properties of glutamate receptors in brain sections from adult and neonatal rats. Brain Res. 740 337-345. 

Klerman GL, DiMascio A, Weissman MM, et al Treatment of depression by drugs and psychotherapy. Am J Psychiatry 131 186-191, 1984 Kleven MS, Seiden LS D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain. Brain Res 505 351-353, 1989 Kligman D, Marshak D Purification and characterization of a neurite extension factor from bovine brain. Proc Natl Acad Sci U S A 82 7136-7139, 1985 Klimek V, Maj J Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2 receptors. J Pharm Pharmacol 41 555-558, 1989 Klinkhamer P, Szelies B, Heiss WD Effect of phosphatidylserine on cerebral glucose metabolism in Alzheimer s disease. Dementia 1 197-201, 1990... 

Buratta S., Mambrini R., Miniaci M. C., Tempia F., and Mozzi R. (2004). Group I metabotropic glutamate receptors mediate the inhibition of phosphatidylserine synthesis in rat cerebellar slices a possible role in physiology and pathology. J. Neurochem. 89 730-738. 

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