2- -3-phenylpropyl

In an investigation of the stereoselectivity of nucleophilic addition to larger ring systems, ethyl-, vinyl-, and ethynyl-lithium and -Grignard reagents have been added to 2-(3 -phenylpropyl)cycloheptanone (69). In all cases, the predominant product is the cw-alcohol, and calculations have been used to identify the steric and torsional effects in the transition state that favour this stereochemistry. 

A novel ionic liquid methodology for pyrrole C-alkylation is described (Equation 136) <20050L1231>. The pyrrole alkylation is achieved with various simple alkyl halides (1-bromopentadecane, l-(bromomethyl)-, l-(3-chloropropyl)- and l-(3-iodopropyl)benzenes, 2-(2-bromoethyl)- and 2-(3-bromopropyl)naphthalenes) and mesylates (3-phenylpropyl-, l-methyl-3-phenylpropyl-, 2-(2-naphthyl)ethyl- and 3-(2-naphthyl)propyl methanesulfonates) selectively at C(2)- and C(5)-positions in good yields with minimal by-products under relatively mild conditions in various ionic liquids. 2-(3-Phenylpropyl)pyrrole 569 was synthesized from pyrrole and l-bromo-3-phenylpropane in a mixed solvent system, [Bmim][SbF6] and MeCN, in 81% yield at 115°C for 44h with 5% yield of dialkylated compound. 

In C-alkylation of other compounds containing nitrogen atoms. Chi s group [35] has done a lot of work. They have described a novel approach for pyrrole C-alkylation in which [BMIM][SbFg] and CH CN as a mixture was onployed for the synthesis of 2-(3-phenylpropyl)pyrrole from pyrrole and 7-bromo-3-phenylpropane with the results that 81% yield was achieved at 115 C for 44 h with 5% yield of dialkylated compound. It is obvious that the ionic Uqnid demonstrated an important driving force in the regioselective alkylation of pyrrole. Moreover, it is worthy to be noted that in this reaction, no Lewis add/base catalysts were needed. 

A series of novel renin inhibitors based on 2- [(3-phenylpropyl)phosphoryl]oxy) alkanoic acid moieties (234)(R = Me, Et, Pr or Bu) and (235)(R = Pr or Bu R as in 234) were prepared as indicated in Scheme 24 diastereoisomers were separated by chromatography on silica gel. The syntheses of, and biological results for, a series of compounds of the general structure (236)(R and R with the same significance as before)... 

Hydrocinnamyl tetrahydrofuran. See 2-(3-Phenylpropyl) tetrahydrofuran Hydrocoil AC-30. See Hydrolyzed collagen Hydrocoll AG-SD. See Gelatin Hydrocoll ALSO, AL-55, EN-40, ENS5-X, EN-SD-1M, EN-SD-10M, Hydrocoll EN-55, Hydrocoll EN-SD. See Hydrolyzed collagen Hydrocoll G-40 Hydrocoll G-55. See Gelatin... 

Phenylpropyltetrahydrofuran. See 2-(3-Phenylpropyl) tetrahydrofuran 2-(3-Phenylpropyl) tetrahydrofuran CAS 3208-40-0 EINECS/ELINCS 221-715-6... 

Phenylpropyl isobutyrate 3-Phenylpropyl isovalerate 3-Phenylpropyl propionate 2-(3-Phenylpropyl) tetrahydrofuran Phenyl salicylate... 

Phenylpropyl) tetrahydrofuran Phenyl salicylate a-Pinene p-Pinene Piperidine Pi peri ne d-Piperitone Piperonyl acetate Piperonyl isobutyrate Potassium acetate Propenylguaethol Propionaldehyde Propyl acetate Propyl alcohol p-Propyl anisole Propyl benzoate Propyl butyrate Propyl cinnamate Propyl disulfide Propyl formate Propyl 2-furanacrylate Propyl heptanoate Propyl hexanoate 3-Propylidenephthalide Propyl isobutyrate... 

Phenyl-3-methyl-3-pentanol 5-Phenyl-1-pentanol 2-Phenylpropanal Phenyl propanol 2-Phenyl propanol-1 Phenylpropionaldehyde 2-Phenylpropionaldehyde dimethylacetal 1-Phenylpropyl acetate 2-(3-Phenylpropyl) tetrahydrofuran Phytol... 

Amyl isovalerate P-Naphthyl methyl ether 2-(3-Phenylpropyl) tetrahydrofuran Snakeroot (Asarum canadense) oil tobacco ingredient Bornyl acetate... 

As with the polyethers, inhibition was selective occurring for most of the organisms for the 4,6-diamino-5-isoamyl-2-(3-phenylpropyl-anaino)-pyrimidine product. 

What happens during hydrolysis is that the OH forms and the elemicin propyl alcohol drops out of solution and forms its own oil layer. Of course one won t see this because the solution is a big old brown mess, lousy with emulsion particles. Emulsions suck But can be dealt with effectively by adding a little acid or base, or filtration and the like. Anyway, after a little work up one gets some really pure phenylpropyl compound. And if Strike had Strike s way. Strike would have that OH stuck right on the middle (beta) carbon of the species. Work could then progress on using that OH to get an amphetamine (Sob Strike had so much about that subject that Strike was prepared to put in this book ). 

Cyhexatin [13121 -70-5], tricyclohexylhydroxystannane (147) (mp 195°C), rat oral 540 mg/kg, and fenbutatin oxide [13356-08-6], hexakis-(2-methyl-2-phenylpropyl)distannoxane (148) (mp 138°C), rat oral LD q 2630 mg/kg, are two novel tin acaricides used on deciduous fmits. They are inhibitors of oxidative phosphorylation. 

Carbon Substituents. Alkyl groups at positions 2 and 4 of a pyridine ring are more reactive than either those at the 3-position of a pyridine ring or those attached to a benzene ring. Carbanions can be formed readily at alkyl carbons attached at the 2- and 4-positions. This increased chemical reactivity has been used to form 2- and 4-(phenylpropyl)pyridines, eg, 4-(3-phenylpropyl)pyridine [2057-49-0] (21) (24). 

Chemical Name 4-hydroxy-3,5-diiodo-0 -[1-[(1-methyl-3-phenylpropyl)amino] ethyl] benzyl alcohol... 

Chemical Name 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester hydrochloride... 

The 3-carbethoxy-3 (1 -phenylpropyl)-4-oxo-dihydrocoumarin may be hydrolyzed and decar-boxylated as follows. The crude product is heated to 85°C for /a hour with 100 parts by volume of 5% aqueous sodium hydroxide, while agitating or stirring. To remove traces of undissolved oil, the cooled solution is treated with 1 part by weight of charcoal, whereupon it is filtrated and acidified to Congo reaction with dilute sulfuric acid. The 3-(1 -phenylpropyl)-4-hydroxycoumarin formed is separated off and recrystallized in 80% ethanol, whereupon it melts at 178°-179°C according to U.S. Patent 2,701,804. 

A -(l-Phenylpropyl)amidcs 3 are enantioselectively synthesized by alkylation of acylimines 2 generated in situ from N-(amidobenzyl)benzotriazoles 1 with diethylzinc in the presence of an enantiomerically pure promoter [(— )-(l/ 2.V)-A,A-dibutylnorcphcdrine, DBNE], The best results are obtained with one equivalent of 1, one equivalent of DBNE and two or three equivalents of diethylzinc in toluene at —78 =C with slow warming to room temperature before workup11. 

In the reaction of 88 with /(-phenethyl bromide, l-phenethyl-3-phenylpropyl methyl sulfoxide and bis-3-phenylpropyl sulfoxide, besides 3-phenylpropyl methyl sulfoxide are obtained118. Sulfoxides, bearing a /1-hydrogen to the sulfmyl function, give olefins upon thermolysis. Utilizing this reaction, Trost and Bridges120 alkylated benzyl phenyl sulfoxide, 3,4-methylenedioxybenzyl phenyl sulfoxide, phenylthiomethyl phenyl sulfoxide, phenylsulfinylmethyl phenyl sulfoxide and cyanomethyl phenyl sulfoxide with alkyl, allyl and benzyl halides and subjected these sulfoxides to thermolysis, obtaining olefins in one-pot processes. 

CN (+)-A/-[2-((Acetylthio)methyl]-l-oxo-3-phenylpropyl]glycine phenylmethyl ester... 

RN 447-41-6 MF Ci HjjNOj MW 299.41 EINECS 207-182-2 CN 4-hydroxy-a-[l-[(l-methyl-3-phenylpropyl)amino]ethyl]benzenemethanol... 

Q4 [25-(2a,5a,6P)]-6-[(l,3-dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-4-thia-l-azabicyclo[3.2.0]heptane-2-carboxylic acid... 

CN [7 -(7 , / )]-2-hydroxy-5-[l-hydroxy-2-[(l-methyl-3-phenylpropyl)amino]ethyl]benzamide monohydrochloride... 

N-[ 1 (S)-ethoxycarbonyl-3-phenylpropyl]-L-olanine tert-butyl ester (l)... 

---