Phenylmethyl alcohol

Triphenylmethyl thioethers have been formed by reaction of the thiol with tri-phenylmethyl alcohol/anhydrous CF3COOH (85-90% yield) or with triphenyl-methyl chloride (75% yield). 

Chemical Designations - Synonyms Benzenecarbinol, alpha-Hydroxytoluene Phenylcarbinol Phenylmethanol Phenylmethyl Alcohol Chemical Formula C HjCHjOH. 

Phenylhydrazine Hydrochloride Phenylhydrazinium Chloride Phenyl Hydroxide Phenylmethanol Phenylmethyl Alcohol Phenylmethyl Amine Phenylphosphine Dichloride Phenylphosphine Thiodichloride Phenylphosphonothioic Dichloride Phenyl Phosphonous Dichloride Phenylpropylene 1 -Phenyltetradecane 1-Phenylundecane Phosgene Phosphoric Acid Phosphoric Sulfide... 

BENZYL ALCOHOL Benzencarbinol, Phenylmethanol, Phenylmethyl Alcohol NL 2 1 0... 

Benzyl Alcohol Benzenecarbinol Alpha- Hydroxytoluene Phenylcarbinol Phenyl- Methanol Phenylmethyl Alcohol... 

PHENYLMETHYL ALCOHOL (100-51-6) Forms explosive mixture with air (flash point 213°F/101°C). Contact with water may cause frothing. Slowly oxidizes in air and oxygen, forming benzaldehyde. Incompatible with mineral acids, caustics, aliphatic amines, isocyanates. Reacts violently with strong oxidizers, and explosive with sulfuric acid at elevated temperature. Corrodes aluminum at high temperature. Attacks some nonfluorinated plastics may not attack polypropylene. 

Synonyms Bentanol Benzal alcohol Benzenecarbinol Benzenemetha-nol Benzoyl alcohol (Hydroxymethyl) benzene Hydroxytoluene a-Hydroxytoluene Phenolcarbinol Phenylcarbinol Phenylmethanol Phenylmethyl alcohol a-Toluenol Classification Aromatic alcohol Empirical CjHsO Formula CsHsCHjOH... 

Phenylmethoxy) methanol. See Benzylhemiformal Phenylmethyl acetate. See Benzyl acetate Phenylmethyl alcohol. See Benz alcohol N-(PhenylmethyD dimethylamine. See N-Benzyidimethylamine Phenyl methyl ethanolamine. See 2-(N-Methylanilino) ethanol Phenyl methyl ketone. See Acetophenone... 

Phenylmethyl alcohol. See Benzyl alcohol (Phenylmethyl) amine. See N-Benzylamine N-Phenylmethylamine. See N-Methylaniline Phenylmethyl benzoate. See Benzyl benzoate... 

Synonyms benzenemethanol phenylcarbinol phenylmethyl alcohol phenylmethanol a-hydroxytoluene benzoyl alcohol hydro-x oluene benzenecarbinol a-toluenol (hydroxymethyl)benzene... 

Phenyl Hydroxide Phenylmethanol Phenylmethyl Alcohol Phenylmethyl Amine Phenylphosphine Dichloride... 

Phenylmethanol Phenylmethyl alcohol. See Benzyl alcohol Phenylmonoglycol ether. See Phenoxyethanol... 

The chemical structures of the majority of FMs that have been studied in wastewater treatment are given in Figs. 1-3. Figure 1 shows a variety of FM structures that include alcohols, aldehydes, and ketones, including benzyl acetate (phenylmethyl ester acetic acid), methyl salicylate (2-hydroxy-methyl ester benzoic acid), methyl dihydrojasmonate (3-oxo-2-pentyl-methyl ester cyclopentaneacetic acid), terpineol (4-trimethyl-3-cyclohexene-1-methanol), benzyl salicylate (2-hydroxy-phenylmethyl ester benzoic acid), isobornyl acetate... 

The oxidation of secondary alcohols (66) to (67) is possible by indirect electrooxidation utilizing thioanisole as an organic redox catalyst in a PhCN-2,6-lutidine-Et4NOTs-(C/Pt) system at 1.5 V vs. SCE (Scheme 25) [81] and is also performed in the presence of 2,2,2-trifluoroethanol [82]. It is suggested that the initially formed cation radical sulfide species derived from the direct discharge of the sulfide provides phenylmethyl-alkoxysulfonium ions, which are transformed to (67) and thioanisole. 

Both of these ethers are prepared easily by nucleophilic displacements (Equations 15-7 and 15-8) and can be converted back to the parent alcohol under mild conditions, by catalytic hydrogenation for phenylmethyl ethers (Equation 15-9), or by mild acid hydrolysis for trimethylsilyl ethers (Equation 15-10) ... 

It should be noted that owing to the great affinity of the phenol for sodium, no sodium alcoholate remains to react with the ethyl iodide. Diethyl ether, however, may be prepared in a similar manner, using the same quantities of sodium, alcohol and ethyl iodide as above. The ether and excess of alcohol are distilled off and the ether separated from the alcohol by the addition of salt solution. Anisole (phenylmethyl ether, B.P. 154°, see p. 218) can also be prepared in a similar way, using corresponding quantities of methyl alcohol and methyl iodide. The alkyl iodides give the best yields, but alkyl chlorides can also be employed. 

Phenylmethyl pyrazolone (see Preparation 252) is methylated with a methyl alcoholic solution of methyl chloride or bromide at 90°—100°, a slight excess of methylating agent being employed. The methylation can he conveniently carried out in an autoclave fitted with an agitator. The alcohol is distilled off, and the reaction product dissolved in water made slightly alkaline with caustic soda. The antipyrine is then extracted with benzene, and crystallised from benzene, and finally from water, animal charcoal being used to decolorise. 

Homogenization buffer, pH 7.4. Concentrations given below indicate the final concentrations. The concentrations of stock solutions that can be used are indicated. 50 mM HEPES (stock solution 1M), 1 mM EDTA 0.5 M (stock solution pH 8.0), 10 mM MgCl2 (stock solution 1M), Protease inhibitor cocktail tablets (see Note 2), 2 iM Pepstatin A (stock solution 1 mM in 100% DMSO), 1 mM phenylmethyl-sulfonyl fluoride (PMSF) (stock solution 50 mM in 100% alcohol) (see Note 2). 

A suspension of zinc (30.6 mmol) in 50 ml THF was treated with 200 xl chlorotrimethyl-silane, stirred 30 minutes at ambient temperature, and then cooled to 0 °C. Phenylmethyl bromide (26.3 mmol) dissolved in 20 ml THF was added and stirred 2 hours. Thereafter, the mixture was treated with CuCN (25 mmol) and LiCl (50 mmol) at -10 °C, briefly stirred, and finally cooled to -70 °C. The product from Step 4 (19.5 mmol) dissolved in 50 ml THF was added, the mixture warmed to 0°C, stirred 1 hour, then quenched by pouring into 100 ml 1M HCl followed by 200 ml CH2CI2. The precipitate was filtered, extracted with CH2CI2, dried, and concentrated. The residue was purified by chromatography on a silica gel column with CH2Cl2/methyl alcohol, 98 2, recrystallized in ethyl alcohol, and the product isolated in 86% yield, mp = 146-147°C. 

SYNS ASCABIN ASCABIOL BENYLATE BENZOIC ACID, PHENYLMETHYL ESTER BENZYL ALCOHOL BENZOIC ESTER BENZYL BENZENE-CARBOXYLATE BENZYL BENZOATE (FCC) BENZYLETS BENZYL PHENYLFORMATE COLEBENZ FEMA No. 2138 NOVOSCABIN PERUSCABIN SCABANCA VANZOATE VENZONATE... 

SYNS BENZYL ALCOHOL CINNAMIC ESTER BENZYL y-PHENYLACRYLATE Q CINNAMEIN trans-CINNAMIC ACID BENZYL ESTER FEMA No. 2142 3-PHENYL-2-PROPENOIC ACID PHENYLMETHYL ESTER (9CI)... 

SYNS BENZYLHYDROSULFIDE BENZYL MERCAPTAN BENZYLTHIOL (MERCAPTOMETH-YL)BENZENE o-MERCAPTOTOLUENE METHANETHIOL, PHENYL- PHENYLMETHAN-ETHIOL PHENYLMETHYL MERCAPTAN THIOBENZYL ALCOHOL a-TOLYL MERCAPTAN USAF EK-1509... 

---