Phenyl methyl ketone

TTie true ketones, in which the >CO group is in the side chain, the most common examples being acetophenone or methyl phenyl ketone, C HjCOCH, and benzophenone or diphenyl ketone, C HjCOC(Hj. These ketones are usually prepared by a modification of the Friedel-Crafts reaction, an aromatic hydrocarbon being treated with an acyl chloride (either aliphatic or aromatic) in the presence of aluminium chloride. Thus benzene reacts with acetyl chloride... 

Acetophenone. Acetophenone [98-86-2] (methyl phenyl ketone) is a colorless Hquid that forms laminar crystals at low temperature (mp 20°C). It has a characteristic sweet orange blossom odor, and is soluble in alcohols and ethers. It is found in nature in oil of casatoreum, obtained from beavers oil of labdanum, recovered from plants and in buds of balsam poplar. It can be prepared by the Friedel-Crafts reaction (qv) of acetyl chloride with benzene in the presence of aluminum chloride however, this route is of Htde commercial significance. 

Acetophenone Methyl phenyl ketone 1.34 CgHgO Hydrogen bromide 226 HBr... 

Methyl phenyl ketone CgHgO 98862 120.151 7.2692E-I-04 3..3783E-I-02... 

While discussing ethers we should mention that the presence of unreacted anisoles or methyl anisoles is highly undesirable in the manufacture of phenol-formaldehyde resoles. These materials tend to be unreactive relative to phenol under normal resole conditions. They are also volatile and have odors detectable at very low concentrations. They have been the source of worker complaints and costly claims in the wood products industry. Benzophenones and methyl phenyl ketones are also common phenol contaminants that are problematic in this regard. 

Methyl phenyl ether, m55 Methyl phenyl ketone, a31 2-Methyl-2-phenylpropane, b523 Methyl y-picolinate, m413... 

Problem 13.11 For the following pairs of halides and carbonyl compounds, give the structure of each alcohol formed by the Grignard reaction, (a) Bromobenzene and acetone, (b) p-Chlorophenol and formaldehyde, (c) Isopropyl chloride and benzaldehyde. (d) Chlorocyclohexane and methyl phenyl ketone. 4... 

KETENES, KETENE DITffiRS AND RELATED SUBSTANCES] (Vol 14) Methyl phenyl ketone [98-86-2]... 

Methyl 2-methyl phenyl ketone, AP28 Methyl 3-methyl phenyl ketone, AP29 Methyl -methylphenyl ketone, AP30 Methyl 2-methylpropenoate, AE51 2-Methyl-2-methylthi opropion-aldehyde, AE73... 

Keywords methyl phenyl ketone, 2-phenyl indole, formylation, Vilsmeier reagent, silica gel, microwave irradiation... 

Methylphenols, c279, c280, c281 Methyl-m-phenylene diisocyanate, tl72 Methyl phenyl ether, m48 Methyl phenyl ketone, a31... 

A decrease in the formation of the Z-isomer in MeOH as solvent is caused by a lowering of the energy of the preferred conformer due to H-bonding. The lack of diastereoselectivity in the case of a-(o-benzylphenyl)methyl phenyl ketone can be explained (Figure 8.1) by considering the difficulty for two benzene rings in the 1,5-biradical to conjugate fully, due to the half-occupied p-orbital. 

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