1- phenyl -1 propanone

Fig. 6 Use of ferredoxin-hydrogenase for NADPH regeneration here in a system for the stereoselective reduction of (2S)-hydroxy-l-phenyl-propanone to (lfi,2S)-phenyl-propane-l,2-diol catalyzed by ADH...

The method was also successful with an a-benzoyloxy ketone, but was unsuccessful with 2-dimethylamino-l-phenylpropanone, which failed to react, and with 2-benzyloxy-l-phenyl-propanone, which reacted with negligible stereoselectivity2,... 

In general, 1.2-diones are good substrates for baker s yeast reduction, however, selectivity is low. In most cases a racemic mixture of the hydroxy ketones and the 1,2-diols is obtained. One exception Lo this rule is the reduction of 1-phenyl-1,2-propanedione to LS )-2-hydroxy-l -phenyl-propanone by baker s yeast in phosphate buffer at pH 5217. If the reaction is carried out with a large excess of yeast in distilled water, the (1 / ,2S)-1-phenyl-1,2-propanediol is obtained in high chemical and optical yield222. 

Synonyms. 2-(Dimethylamino) propiophenone 2-(Dimethylamino)-l-phenyl-propanone N-Methylephedrone Dimepropion a-(Dimethylamino) propiophenone Benzoyl-a-dimethyl-amino ethane. 

Solvent effects were studied in the enantioselective hydrogenation of l-phenylpropane-l,2-dione over Pt-alumina-Cnd catalyst. The ee values and reaction rates are dependent on the hydrogen solubilities and dielectric constants in different solvents. The highest ee, 65%, of (i )-1-hydroxy-1-phenyl-propanone was obtained in toluene. It decreased non-linearly with increasing solvent dielectric constant becoming close to zero in MeOH (Toukonitty et al. )... 

Chem. Descrip. Esacure KIP 150 (oligo [2-hydroxy-2-methyl-1-[4-(1-methylvinyl) phenyl] propanone] (75%) and tripropyleneglycol diactylate... 

Chem. Descrip. Oligo (2-hydroxy-2-methyl-1-4 (1-methylvinyl) phenyl propanone and 2-hydroxy-2-methyl-1 -phenyl-1 -propanone (monomeric) Uses Photoinitiator for adhesives, coatings, electronics, inks Features Highly reactive nonyellowing fast cure response good through cure low color and odor (cured film) low volatility optimum absorp. 263-325 nm... 

Chem. Descrip. Oligo (2-hydro) -2-methyl-1-4 (1-methylvinyl) phenyl propanone emulsion... 

Turro et al. studied the effect of substituents upon the efficiency of 2-hydroxy-2-methyl-l-phenyl propanone in initiation of polymerization of acrylic monomers. The parent compound decomposes in the following manner ... 

C2sH Br,0 2.3-Dibrom-3-phwM-[4-biom-phenyl]-propanon.(l) 7II 382. 

Phenyl-1.3-bis-[4-methojy-phenyl]-propanon-(S) 8 II420.. Phenyl- x.a-biB-[4-inetboxy-pheiiyl]-propionald yd 8 1 672. 

GnHqCIN0( 2-Chlor-3-benzamino-1.3.di> phenyl-propanon-(l) 14 II86. 

For example, a ferredoxin hydrogenase (EC 1.12.7.2) has been isolated recently from the hyperthermophile Pyrococcus fUriosus [38]. The performance of this biocatalyst, which showed a remarkable stability under operative conditions, has been investigated for the NADPH regeneration in the reduction of prochiral ketones catalyzed by the thermophilic NADPH-dependent ADH from Thermoanaerohium sp. Total turnover numbers (TTNs mole product/mole consumed cofactor NADP" ") of 100 and 160 could be estimated in the reduction of acetophenone and (2S)-hydroxy-l-phenyl-propanone, respectively. As a side note, it should be mentioned that, although the activity of the P. furiosus hydrogenase increased exponentially with temperature up to its maximum above 80 °C, the reactions had to be performed at much lower temperature (40 °C) because of the thermal instability of NADPH. 

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