Phenyl-2-propanone, structure

Compare electrostatic potential maps of enolates derived from 2-butanone, 4,4-dimethyl-2-pentanone, 4,4,4-trifluoro-2-butanone and l-phenyl-2-propanone with those of acetone. Which substituents cause significant changes in the electronic structure of these enolates and what are the nature of these changes Justify your answers by making drawings of any important resonance contributors. 

Chemical Name 2-(Diethylamino)-l-phenyl-l-propanone hydrochloride Common Name Amfepramone Structural Formula ... 

Draw structures for these compounds a) (Z)-Oct-3-en-2-one c) 2,4-PentadienaI e) 1-Phenyl-1-propanone... 

The other factor that may determine the type of cell death is the chemical structure of inducing agents [14]. We have recently found that u,(>-unsaluraled ketones such as 4,4-dimethyl-2-cyclopenten-l-one, a-methy-lene-y-butyrolactone, 5,6-dihydro-2H-pyran-2-one [15], codeinone [16], and morphinone [17] and a-hydroxylketones such as 3,3,3-trifluoro-2-hydroxy-1-phenyl-1-propanone induced caspase-independent cell death [18], induced vacuolization or autophagosome formation engulfing organelles, but without induction of apoptosis markers. 

Thietanones also have been obtained by treatment of aliphatic ketones with an a-methylene group with thionyl chloride, usually in the presence of a base as shown for the synthesis of 359. A 3-thietanone was suggested as a possible structure for the product obtained by the acid-catalyzed hydrolysis of the bis-thioglycolic thioacetal of substituted benzaldehydes, but an elemental analysis was the only evidence. Treatment of l-diazo-3-phenylthio-2-propanone with acid gives the -phenyl salt of 3-thietanone (Section VII.1.). Similar 5-alkyl salts may be intermediates, but they readily decompose either by loss of the 5-alkyl group or... 

Hydroxy Alkyl Phenyl Ketones The basic structures, 2-hydroxy-2-methyl-l-phenyl-1-propanone HAP and 1-hydroxy-cyclohexyl-1-phenyl ketone HCAP, are also well known [17] and still largely used (10.10) and studied [2i,f,18]. The para substitution of the benzoyl group (with an amino, an ether, or a thioether group) drastically changes the electronic transitions but does not significantly affect the reactivity of the derived benzoyl initiating radical. 

The title compounds, aryl substituted 3-phenyl-l,l,l-trlfluoro-2-propanones of Structure A, were synthesized from the appropriate thlophenol using 3-bromo-l,1,l-trifluoro-2-propanone (BTFA) and trlethylamine according to the previously published procedure (Z. ) I general, the products were formed at good yields (80-... 

Borohydride reduction of ketones. The reduction of ketones to alcohols by sodium borohydride in benzene-water has been reported to be catalyzed by this salt (6, 249). However, no asymmetric induction was noted in the case of 2-octanone, 1-phenyl-1-propanone, or acetophenone. More recently, asymmetric induction has been observed with more hindered ketones. The maximum was observed with r-butyl phenyl ketone when an enantiomeric excess of 14% of the (R)-alcohol could be obtained. The enantiomeric excess is only 3.6% in the reduction of isopropyl phenyl ketone. No asymmetric induction was observed when ( —)(R)-N,N-dimethyl-N-dodecylamphetaminium bromide was used as catalyst. The structure of the chiral catalyst is evidently important. ... 

Normally water-insoluble drugs with a phenyl ring can form molecular complexes with surfactants. The chemical structures of l-(2,4,6-trihydroxyphenyl)-l-propanone (flopro-pione), an anti-spasmodic, and 4-chloro-m-cresol (a germicide) are shown in Figure 4.34. They became soluble in aqueous solutions in the presence of surfactants, probably because of complex formation. In order to understand the nature of complex formation, the cationic surfactants CTAB and MTAB were used. The complex crystals between CTAB and 4-chrolo-m-cresol (XXIII), MTAB and flopropione (XXIV), and CTAB and flopropione (XXV) were obtained from the solutions of methanol, methanol and aqueous solutions, respectively. 

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