1- PROPANONE, 2,2-dimethyl-l-phenyl

KETONE, ferf-butyl phenyl [1-Propanone, 2,2-dimethyl-l-phenyl-], 55, 122 Ketone, methyl ethyl- [2-Butanone, 55, 25 KFTONES, acetylenic [Ketones, ethynic]... 

A solution of 20.7 g (0.1 mmol) of (46 ,56 )-5-amino-2.2-dimethyl-4-phenyl-l,3-dioxane and 19.4 g (0.1 mol) of 3,4-dimethoxyphenyl-2-propanone in 70 mL of CH3OH is warmed to 60 "C and 9 mL of acetic acid is added. After 15 min the mixture is cooled with an ice bath. The precipitated product is filtered off, stirred with 1 L of water for 1 h to dissolve inorganic salts, and again collected by filtration. Drying over NaOH and recrystallization from CH3OH gives the product yield 33.6 g (82%) mp 127 128°C [a] 2 + 85.7 (c = 1, CHC1,). 

Preparation of a,a-Dimethyl- 3-Phenylpropionamide Sodamide was prepared from 7.6 grams of sodium in 350 cc of liquid ammonia with 0.9 gram of hydrous ferric chloride. The ammonia was replaced by 250 cc of toluene, the mixture was heated to 60°C and 71.4 grams of l,3-diphenyl-2,2-dimethyl propanone-1 dissolved in 150 cc of toluene was added. The mixture was stirred and heated on a steam bath for 5 hours. A clear red color appeared in 15 minutes and disappeared after about an hour. After cooling, water was added, the organic layer was washed, dried, and concentrated to give 36.5 grams of a,a-dimethyl-p-phenyl propionamide which crystallized slowly after the addition of an equal volume of petroleum ether. The product melted at 62°C after crystallization from benzene-petroleum ether. 

Synonyms. 2-(Dimethylamino) propiophenone 2-(Dimethylamino)-l-phenyl-propanone N-Methylephedrone Dimepropion a-(Dimethylamino) propiophenone Benzoyl-a-dimethyl-amino ethane. 

Contrast and compare the relative acidities of 1-phenyl-l-ethanone, 1-phenyl-1-propanone, 2-methyl-l-phenyl-l-propanone, and 2,2-dimethyl-l-phenyl-l-propanone. 

Acetyl-6-hydroxyphenyl)-2,2-dimethyl-1 -propanone, 2171 1 -[3-(Cyclopropyhnethyl)-2,4-dihydroxyphenyl]-1 -propanone, 1885 1 -[2-Hydroxy-4-methoxy-5-(2-propenyl)phenyl]-1 -propanone, 1885 l-[2-Hydroxy-5-methoxy-3-(2-propenyl)phenyl]-l-propanone, 1885 1 -[2-Hydroxy-6-methoxy-3-(2-propenyl)phenyl]-1 -propanone, 1885 1 -[4-Hydroxy-2-methoxy-5-(2-propenyl)phenyl]-1 -propanone, 1886 1,1 -(2-Hydroxy-5-methyl-1,3-phenylene)bis-1 -propanone, 2111 1,1 -(4-Hydroxy-5-methyl-1,3-phenylene)bis-1 -propanone, 2111 l,l -(4-Methoxy-l,3-phenylene)bis-1 -propanone, 2111 1 - [2-Methoxy-4-(2-propenyloxy)phenyl] -1 -propanone, 1886 1 - [2-Methoxy-6-(2-propenyloxy)phenyl] -1 -propanone, 1886... 

Hydroxy[ 1,1 -biphenyl]-3-yl)-2,2-dimethyl- 1-propanone, 2097 l-[2-Hydroxy-5-(phenylethyl)phenyl]-l-propanone, 1941 1 -(4-Methoxy[ 1,1 -biphenyl]-3-yl)-2-methyl-1 -propanone, 2052 l-[4-Methoxy-3-(phenylinethyl)phenyl]-l-propanone, 1941... 

Acetyl-2,4-dihy droxy-6-methoxy-5-methylpheny l)methyl]-3,4-dihydro-3,5,7-trihydroxy-2,2-dimethyl-2H-1 -benzopyran-8-yl] -2-methyl-1 -propanone, 2163 1 - [3 - [(3 - Acetyl-2,4-dihydroxy-6-methoxy-5-methylphenyl)methyl] -2,4,6-trihydroxy-5-(2-hydroxy-3-methyl-3-butenyl)phenyl]-2-methyl-1 -propanone, 2163 l-[2,4,6-Trihydroxy-3-(2-methyl-l-oxopropyl)-5-[[2,4,6-trihydroxy-3-methyl-5-(1 -oxobutyl)-phenyl]methyl]phenyl] -1 -butanone, 2164... 

The other factor that may determine the type of cell death is the chemical structure of inducing agents [14]. We have recently found that u,(>-unsaluraled ketones such as 4,4-dimethyl-2-cyclopenten-l-one, a-methy-lene-y-butyrolactone, 5,6-dihydro-2H-pyran-2-one [15], codeinone [16], and morphinone [17] and a-hydroxylketones such as 3,3,3-trifluoro-2-hydroxy-1-phenyl-1-propanone induced caspase-independent cell death [18], induced vacuolization or autophagosome formation engulfing organelles, but without induction of apoptosis markers. 

Cyclolycoserone, C-70229 Cyclolycoserone 3 -Epimer, in C-70229 l-(2,4-Dihydroxyphenyl)-3-[3,4-dihydroxy-2-(3,7-dimethyl-2,6-octadienyl)phenyl]-1 -propanone, D-80357 I -Epilycoscronc, m L-70045... 

Ethyl-6-hydroxy-4-methylphenyl)-1 -propanone, 1866 1 -(3-Ethyl-4-hydroxy-5-methylphenyl)-1 -propanone, 1866 1 -(5-Ethyl-2-hydroxy-3-methylphenyl)-1 -propanone, 1867 1 -(5-Ethyl-2-hydroxyphenyl)-2-methyl-1 -propanone, 2031 1 -(2-Ethyl-3-methoxyphenyl)-1 -propanone, 1867 1 -(2-Ethyl-6-methoxyphenyl)-1 -propanone, 1867 1 -(3-Ethyl-4-methoxyphenyl)-1 -propanone, 1867 1 -(4-Ethyl-2-methoxyphenyl)-1 -propanone, 1868 1 -(2-Hydroxy-3,5-dimethylphenyl)-2-methyl-1 -propanone, 2031 1 -(2-Hydroxy-4,5-dimethylphenyl)-2-methyl-1 -propanone, 2031 1 -(2-Hydroxy-4,6-dimethylphenyl)-2-methyl-1 -propanone, 2032 l-(4-Hydroxy-3,5-dimethylphenyl)-2-methyl-l-propanone, 2032 1 - [2-Hydroxy-4-( 1 -methylethyl)pheny 1]-1 -propanone, 1868 1 - [2-Hydroxy-5-( 1 -methylethy l)pheny 1]-1 -propanone, 1868 1 - [4-Hydroxy-3 -(1 -methylethy l)phenyl]-1 -propanone, 1868 l-(2-Hydroxy-4-methylphenyl)-2,2-dimethyl-l-propanone, 2086 l-(2-Hydroxy-5-methylphenyl)-2,2-dimethyl-l-propanone, 2087 l-(4-Hydroxy-3-methylphenyl)-2,2-dimethyl-l-propanone, 2087 l-(2-Hydroxy-5-methylphenyl)-l-propanone (Ethyl ether), 1804 1 -(2-Hydroxy-3-propylpheny 1)-1 -propanone, 1868 1 -(2-Hydroxy-4-propylpheny 1)-1 -propanone, 1869 1 -(2-Hydroxy-5-propylpheny 1)-1 -propanone, 1869 1 -(4-Hydroxy-3-propylpheny 1)-1 -propanone, 1869 1 -(2-Methoxy-3,4-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-3,5-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-3,6-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-4,5-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-4,6-dimethylphenyl)-l -propanone, 1870 1 -(4-Methoxy-2,3 -dimethylphenyl)-1 -propanone, 1871 1 -(4-Methoxy-2,5-dimethylphenyl)-l -propanone, 1871 1 -(4-Methoxy-2,6-dimethylphenyl)-l -propanone, 1871 1 -(4-Methoxy-3,5-dimethylphenyl)-l -propanone, 1871 1 -(2-Methoxy-3-methylphenyl)-2-methyl-1 -propanone, 2032 l-(2-Methoxy-4-methylphenyl)-2-methyl-l-propanone, 2033 l-(2-Methoxy-5-methylphenyl)-2-methyl-l-propanone, 2033 l-(3-Methoxy-4-methylphenyl)-2-methyl-l-propanone, 2033 1 -(4-Methoxy-2-methylphenyl)-2-methyl-1 -propanone, 2033... 

Dihydroxy-3-propylphenyl)-2-methyl-1 -propanone, 2040 1 -(2,4-Dimethoxy-3,5-dimethylphenyl)-1 -propanone, 1899 l-(2,3-Dimethoxy-5-methylphenyl)-2-methyl-l-propanone, 2040 1 -(3,4-Dimethoxy-2-methylphenyl)-2-methyl-1 -propanone, 2040 l-(3,4-Dimethoxy-5-methylphenyl)-2-methyl-l-propanone, 2041 1 -(2,4-Dimethoxyphenyl)-2,2-dimethyl-1 -propanone, 2092 1 -(2,5-Dimethoxyphenyl)-2,2-dimethyl-1 -propanone, 2093 1 -(3,4-Dimethoxyphenyl)-2,2-diniethyl-1 -propanone, 2093 1 - [2-( 1,1 -Dimethylethoxy)-6-hydroxyphenyl] -1 -propanone, 1899 1 - [5-( 1,1 -Dimethylethyl)-2,4-dihydroxyphenyl] -1 -propanone, 1899 l-(3-Ethoxy-4-hydroxyphenyl)-l-propanone (Ethyl ether), 1845 1 -(2-Ethyl-4,5-dimethoxyphenyl)-1 -propanone, 1899 1 -(4-Ethyl-2,5-dimethoxyphenyl)-1 -propanone, 1900 l-(4-Ethyl-3,5-dimethoxyphenyl)-l-propanone, 1900 1 -(5-Ethyl-2,4-dimethoxyphenyl)-1 -propanone, 1900 1 - [4-Hydroxy-3 -methoxy-5-( 1 -methylethyl)phenyl] -1 -propanone, 1900 l-(4-Hydroxy-3-methoxyphenyl)-l-propanone (Propyl ether), 1817 1 -(2-Hydroxy-6-methoxy-3 -propylphenyl)-1 -propanone, 1901 1 -(4-Hydroxy-3 -methoxy- 5-propylphenyl)-1 -propanone, 1901 1 - [4-Hydroxy-3 -[(1 -methylethoxy)methyl]phenyl] -1 -propanone, 1901 1 - [4-Hydroxy-3 -(propoxymethyl)phenyl] -1 -propanone, 1901 l-[3-(Hydroxymethyl)-4-methoxyphenyl]-2,2-dimethyl-l-propanone, 2093 1 - [ 3 - (1 -Hy droxypropy 1) -4-methoxypheny 1] -1 -propanone, 1902 l-[5-(l-Hydroxypropyl)-2-methoxyphenyl]-l-propanone, 1902... 

Butyl-2,4,6-trihydroxyphenyl)-2-methyl-1 -propanone, 2045 1 -[2,4-Dimethoxy-5-( 1 -hydroxypropyl)phenyl]-1 -propanone, 1915 1 -[2,6-Dimethoxy-3-( 1 -hydroxypropyl)phenyl]-1 -propanone, 1915 2,2-Dimethyl-l-(2,4,6-trimethoxyphenyl)-l-propanone, 2094 l-(2-Hydroxy-4,6-dimethoxy-3,5-dimethylphenyl)-2-methyl-l-propanone, 2045 l-(4-Hydroxy-3,5-dimethoxyphenyl)-l-propanone (Propyl ether), 1854... 

Hydroxy-3-methyl-6-phenyl-2-benzofuranyl)-2,2-dimethyl-l-propanone, 2103... 

Methyl-l-[2,4,6-trihydroxy-3-(3-hydroxy-3,7-dimethyl-6-octenyl)phenyl]-1-propanone, 2057... 

Methoxyphenyl-2,6-dj)-2-methyl-1 -propanone, 2021 l-(2,3,5-Trihydroxyphenyl)-l-propanone, 1773 l-(2,3,6-Trihydroxyphenyl)-l-propanone, 1773 l-[2-Methoxy-6-(2-pyridinyl)phenyl]-l-propanone, 2004 l-[5-Methoxy-2-(2-pyridinyl)phenyl]-l-propanone, 2005 l-(2,5-Dihydroxy-3,4-dipropylphenyl)-l-propanone, 1929 l,l -(2,2 -Dihydroxy[l,l -binaphthalene]-6,6 -diyl)bis[2,2-dimethyl-l-propanone (racemic), 2170 l,l -(2,2 -Dihydroxy[l,l -binaphthalene]-6,6 -diyl)bis[2,2-dimethyl-l-propanone (IR), 2170 1,1 -(2,2 -Dihydroxy [ 1,1 -binaphthalene]-6,6 -diyl)bis[2,2-dimethyl-l-propanone (15), 2170 2,2-Dimethyl-l-(3, 4, 5 -trimethoxy[l,l -biphenyl]-2-yl)-l-propanone, 2099... 

Hyperevoline. l,l -(l,7a,13a,13b-Tetrahydro-5,8,10-trihydroxy-2,2,6,9,13, 13-hexamethyl-2H, 13H-bis-l-benzopyrano[5,4-bc 3, 4 -e]pyran-4,ll-diyl) bis[2-methyl-l-propanone (7aoc, 13aoc, 13bP), 2155-2156 Hyperjovinol A. 2-Methyl-1 -[2,4,6-trihydroxy-3-(3-hydroxy-3,7-dimethyl-6-octenyl)phenyl]-l -propanone, 2057... 

P-Kosin. 1 -[3-[[2-Hydroxy-4,6-dimethoxy-3-methyl-5-( 2-methyl-l -oxopropyl) phenyl] methyl]-2,4,6-trihydroxy-5-methylphenyl]-2-methyl-l -propanone, 2150 Kosotoxin. 4-[[2,6-Dihydroxy-4-methoxy-3-methyl-5-(2-methyl-l-oxopropyl)-phenyl]methyl]-3,5-dihydroxy-2,4-dimethyl-6-(2-methyl-l-oxopropyl)-2,5-cyclohexadien-l-one, 2148-2149... 

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