1- PROPANONE, 2,2-dimethyl-1-phenyl

Preparation of a,a-Dimethyl- -Phenylpropionamide Sodamide was prepared from 7.6 grams of sodium in 350 cc of liquid ammonia with 0.9 gram of hydrous ferric chloride. The ammonia was replaced by 250 cc of toluene, the mixture was heated to 60°C and 71.4 grams of 1,3-diphenyl-2,2-dimethyl propanone-1 dissolved in 150 cc of toluene was added. The mixture was stirred and heated on a steam bath for 5 hours. A clear red color appeared in 15 minutes and disappeared after about an hour. After cooling, water was added, the organic layer was washed, dried, and concentrated to give 36.5 grams of a,a-dimethyl- -phenyl propionamide which crystallized slowly after the addition of an equal volume of petroleum ether. The product melted at 62°C after crystallization from benzene-petroleum ether. 

Compare electrostatic potential maps of enolates derived from 2-butanone, 4,4-dimethyl-2-pentanone, 4,4,4-trifluoro-2-butanone and l-phenyl-2-propanone with those of acetone. Which substituents cause significant changes in the electronic structure of these enolates and what are the nature of these changes Justify your answers by making drawings of any important resonance contributors. 

A solution of 20.7 g (0.1 mmol) of (46 ,56 )-5-amino-2.2-dimethyl-4-phenyl-l,3-dioxane and 19.4 g (0.1 mol) of 3,4-dimethoxyphenyl-2-propanone in 70 mL of CH3OH is warmed to 60 "C and 9 mL of acetic acid is added. After 15 min the mixture is cooled with an ice bath. The precipitated product is filtered off, stirred with 1 L of water for 1 h to dissolve inorganic salts, and again collected by filtration. Drying over NaOH and recrystallization from CH3OH gives the product yield 33.6 g (82%) mp 127 128°C [a] 2 + 85.7 (c = 1, CHC1,). 

KETONE, ferf-butyl phenyl [1-Propanone, 2,2-dimethyl-l-phenyl-], 55, 122 Ketone, methyl ethyl- [2-Butanone, 55, 25 KFTONES, acetylenic [Ketones, ethynic]... 

Exercise 17-14 The Haller-Bauer cleavage of 2,2-dimethyl-1-phenyl-1-propanone with sodium amide forms benzenecarboxamide and 2-methylpropane. Write a mechanism for the Haller-Bauer reaction analogous to the haloform cleavage reaction. 

The other factor that may determine the type of cell death is the chemical structure of inducing agents [14]. We have recently found that u,(>-unsaluraled ketones such as 4,4-dimethyl-2-cyclopenten-l-one, a-methy-lene-y-butyrolactone, 5,6-dihydro-2H-pyran-2-one [15], codeinone [16], and morphinone [17] and a-hydroxylketones such as 3,3,3-trifluoro-2-hydroxy-1-phenyl-1-propanone induced caspase-independent cell death [18], induced vacuolization or autophagosome formation engulfing organelles, but without induction of apoptosis markers. 

C9H10N2 2,3-dimethyl-2H-indazole 50407-18-6 559.15 49.595 1,2 16666 C9H10O2 2-hydroxy-1-phenyl-1-propanone 5650-40-8 524.15 46.209 1,2... 

Probkm 28.28 Using 9-BBN plus any alkenes and unhalogenated acids or ketones, outline all steps in the synthesis of (a) 2-heptanone (b) 4-methylpentanoic acid (c) 4-methyl-2-hexanone (d) l-cyclohexyl-2-propanone (e) ethyl (trans Z-methylcyclopentyl)acetate (f) l>phenyl-4-methyM-pentanone (g) i-cyclopentyl-33 dimethyl-2-butaBone. 

Synonyms. 2-(Dimethylamino) propiophenone 2-(Dimethylamino)-l-phenyl-propanone N-Methylephedrone Dimepropion a-(Dimethylamino) propiophenone Benzoyl-a-dimethyl-amino ethane. 

Borohydride reduction of ketones. The reduction of ketones to alcohols by sodium borohydride in benzene-water has been reported to be catalyzed by this salt (6, 249). However, no asymmetric induction was noted in the case of 2-octanone, 1-phenyl-1-propanone, or acetophenone. More recently, asymmetric induction has been observed with more hindered ketones. The maximum was observed with r-butyl phenyl ketone when an enantiomeric excess of 14% of the (R)-alcohol could be obtained. The enantiomeric excess is only 3.6% in the reduction of isopropyl phenyl ketone. No asymmetric induction was observed when ( —)(R)-N,N-dimethyl-N-dodecylamphetaminium bromide was used as catalyst. The structure of the chiral catalyst is evidently important. ... 

Hydroxy-4,5-dihydroxymethyl-2-methylpyridine HCI. See Pyridoxine HCI a-Hydroxy-a,a,a-dimethylacetophenone. See 2-Hydroxy 2-methyl 1-phenyl 1-propanone m-Hydroxy-N,N-dimethyl aniline. See Dimethylaminomethyl phenol Hydroxydimethylarsine oxide. See Cacodylic acid... 

Contrast and compare the relative acidities of 1-phenyl-l-ethanone, 1-phenyl-1-propanone, 2-methyl-l-phenyl-l-propanone, and 2,2-dimethyl-l-phenyl-l-propanone. 

Dimethyl-1 -phenyl-1 -propanone, D-60443 (3-Hydroxyphenoxy)acetic acid Me ether, Et ester, in H-70204... 

Cyclolycoserone, C-70229 Cyclolycoserone 3 -Epimer, in C-70229 l-(2,4-Dihydroxyphenyl)-3-[3,4-dihydroxy-2-(3,7-dimethyl-2,6-octadienyl)phenyl]-1 -propanone, D-80357 I -Epilycoscronc, m L-70045... 

Methyl-l-[2,4,6-trihydroxy-3-(3-hydroxy-3,7-dimethyl-6-octenyl) phenyl]-l propanone (Hyperjovinol A)... 

Ethyl-6-hydroxy-4-methylphenyl)-1 -propanone, 1866 1 -(3-Ethyl-4-hydroxy-5-methylphenyl)-1 -propanone, 1866 1 -(5-Ethyl-2-hydroxy-3-methylphenyl)-1 -propanone, 1867 1 -(5-Ethyl-2-hydroxyphenyl)-2-methyl-1 -propanone, 2031 1 -(2-Ethyl-3-methoxyphenyl)-1 -propanone, 1867 1 -(2-Ethyl-6-methoxyphenyl)-1 -propanone, 1867 1 -(3-Ethyl-4-methoxyphenyl)-1 -propanone, 1867 1 -(4-Ethyl-2-methoxyphenyl)-1 -propanone, 1868 1 -(2-Hydroxy-3,5-dimethylphenyl)-2-methyl-1 -propanone, 2031 1 -(2-Hydroxy-4,5-dimethylphenyl)-2-methyl-1 -propanone, 2031 1 -(2-Hydroxy-4,6-dimethylphenyl)-2-methyl-1 -propanone, 2032 l-(4-Hydroxy-3,5-dimethylphenyl)-2-methyl-l-propanone, 2032 1 - [2-Hydroxy-4-( 1 -methylethyl)pheny 1]-1 -propanone, 1868 1 - [2-Hydroxy-5-( 1 -methylethy l)pheny 1]-1 -propanone, 1868 1 - [4-Hydroxy-3 -(1 -methylethy l)phenyl]-1 -propanone, 1868 l-(2-Hydroxy-4-methylphenyl)-2,2-dimethyl-l-propanone, 2086 l-(2-Hydroxy-5-methylphenyl)-2,2-dimethyl-l-propanone, 2087 l-(4-Hydroxy-3-methylphenyl)-2,2-dimethyl-l-propanone, 2087 l-(2-Hydroxy-5-methylphenyl)-l-propanone (Ethyl ether), 1804 1 -(2-Hydroxy-3-propylpheny 1)-1 -propanone, 1868 1 -(2-Hydroxy-4-propylpheny 1)-1 -propanone, 1869 1 -(2-Hydroxy-5-propylpheny 1)-1 -propanone, 1869 1 -(4-Hydroxy-3-propylpheny 1)-1 -propanone, 1869 1 -(2-Methoxy-3,4-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-3,5-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-3,6-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-4,5-dimethylpheny 1)-1 -propanone, 1870 1 -(2-Methoxy-4,6-dimethylphenyl)-l -propanone, 1870 1 -(4-Methoxy-2,3 -dimethylphenyl)-1 -propanone, 1871 1 -(4-Methoxy-2,5-dimethylphenyl)-l -propanone, 1871 1 -(4-Methoxy-2,6-dimethylphenyl)-l -propanone, 1871 1 -(4-Methoxy-3,5-dimethylphenyl)-l -propanone, 1871 1 -(2-Methoxy-3-methylphenyl)-2-methyl-1 -propanone, 2032 l-(2-Methoxy-4-methylphenyl)-2-methyl-l-propanone, 2033 l-(2-Methoxy-5-methylphenyl)-2-methyl-l-propanone, 2033 l-(3-Methoxy-4-methylphenyl)-2-methyl-l-propanone, 2033 1 -(4-Methoxy-2-methylphenyl)-2-methyl-1 -propanone, 2033... 

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