Proximal tubular injury

The authors thought that this was the first report of acute transient proximal tubular injury with ecstasy. In contrast to SIADH, there was a high urine output in the presence of hyponatremia and solute diuresis. [Pg.605]

Endre ZH, Ratcliffe PJ, Tange JD, Ferguson DJ, Radda GK, Ledingham JG Erythrocytes alter the pattern of renal hypoxic injury predominance of proximal tubular injury with moderate hypoxia. Clin.Sci. 76 19-29,1989... [Pg.207]

EdelsteinCE Editorial Comment Calcium-mediated proximal tubular injury-what is the role of cysteine proteases Nephrol.Dial. Transplant. 15 141 -144,2000... [Pg.208]

Zager RA, Johnson AC, Flanson SY, Lund S, Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-a generation and systemic release. Am J Physiol, 2005, 289 F289-97. [Pg.291]

Nortier JL, Deschodt-Lanckman MM, Simon S,Thielemans NO, de Prez EG, Depierreux MF,Tielemans CL, Richard C, Lauwerys RR, Bernard AM, Vanherweghem JL. Proximal tubular injury in Chinese herbs nephropathy monitoring by neutral endopeptidase... [Pg.766]

Bames JL, McDowell EM, McNeil JS, et al. 1980. Studies on the pathophysiology of acute renal failure. V. Effect of chronic saline loading on the progression of proximal tubular injury and functional impairment following administration of mercuric chloride in the rat. Vichows Arch B 32 233-260. [Pg.583]

Pfaller W, Thorwartl U, Nevinny-Stickel M, Krall M, Schober M, Joannidis M, Hobisch A (1994) Clinical value of fructose 1,6 bisphos-phatase in monitoring renal proximal tubular injury. Kidney Int Suppl 47 S68-S75... [Pg.474]

Daemen MARC, Van t Veer C, Denecker G, Heemskerk VH, Wolfs TGAM, Clauss M, Vandenabeele P, Buurman W Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J.CIin.Invest. 104 541-549, 1999 Edelstein CL Editorial Comment Calcium-mediated proximal tubular injury-what is the role of cysteine proteases Nephrol.Dial.Transplant. 15 141-144, 2000... [Pg.104]

Nouwen EJ, Verstrepen WA, Buyssens N, Zhu MQ, De Broe ME. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab Invest 1994 479-493. [Pg.167]

Proximal tubular injury due to nephrotoxicants occurs more frequently than other nephrotoxic effects, and this probably reflects a combination of the proportion of the total renal blood supply received by the renal cortex and the number of xenobiotics reabsorbed and excreted within the proximal tubule. Xenobiotics can alter or inhibit the transport processes of passive diffusion and/or carrier transporters for both anionic/base and cationic molecules. [Pg.72]

Celluria can indicate proximal tubular injury (Davies and Kennedy 1967 Prescott and Ansari 1969), but it does not occur in every case. Celluria may occur after an initial delay following dosing peak and then be absent even during continued treatment or rechallenge. Cellular examinations do not appear to be useful when investigating chronic tubular injury and acute distal tubular damage except to confirm hematuria. [Pg.81]

Kanki, M., et al.. Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats. Toxicology, 2014. 324 p. 158-68. [Pg.451]

Adults a50 ig/dl PbB Chronic occupational Pb nephropathy Mainly proximal tubular injury hyperuricemia Wedeen etal. (1986), Coyer (1989), NAS/ NRC(1972)... [Pg.416]

Chisolm (1962, 1968) recorded the presence of the full Fanconi Syndrome of toxic proximal tubular injury in young children, i.e., aminoaciduria, gluco-suria, and hyperphosphaturia, while other researchers have described elevated urinary levels of amino acids or glucose. The threshold in PbB associated with early tubular injury in acute childhood lead poisoning leading to Fanconi Syndrome was reported as typically >150 pg/dl, and lower levels of Pb,... [Pg.570]

Variably aged subjects Acute Pb exposures Kidney injury sites Proximal tubular injury Pejic (1928)... [Pg.571]

Variably aged subjects High exposures of variable duration Early proximal tubular injury Formation of tubular cell intranuclear inclusion bodies, mitochondrial changes, tubular cytomegaly Blackman (1936), Cramer etal. (1974)... [Pg.571]

Lesser or earlier manifestations of kidney injury appear to be associated with lower levels of Pb exposure, as would be expected in dose—response terms. Chia et al. (1995b) reported that urinary ai-microglobulin was increased in Pb workers with a mean PbB of 33 p.g/dl versus a control group mean of 9 pg/dl, while Dos Santos et al. (1994) found that urinary NAG, a biomarker for early kidney proximal tubular injury, was elevated and positively correlated with duration of Pb exposure. [Pg.577]

MinowaY, Kondo C, UeharaT et al (2012)Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats. Toxicology 297 47-56. doi 10.1016/j. tox.2012.03.014... [Pg.366]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...