Pharmacological Activities and Clinical Trials

Adverse effects. A causal role of acute cannabis intoxication in motor vehicle and other accidents has been shown by the pres- 

Amnesic syndrome. A 26-year-old woman suffered disseminated intravascular coagulation (Die) and a brief respiratory arrest fol- 

Amyotrophic lateral sclerosis. One hundred thirty one respondents with amyotrophic lateral sclerosis—13 of whom reported using cannabis in the last 12 months—were examined. The results indicated that cannabis might be moderately effective at reducing symptoms of appetite loss, depression, pain, spasticity, and drooling. Cannabis was reported ineffective in reducing difficulties with speech and swallowing, and sexual dysfunction. The longest relief was reported for depression (approx 2-3 hours 

Analgesic activity. Ethanol (50%) extract of the entire plant, administered intraperi-toneally to mice at a dose of 250 mg/kg, was active vs tail pressure method Flavonoid fraction of the leaf, administered intraperi-toneally to mice, was active 5 The inflorescence, administered orally to male rats, produced weak activity vs paw pressure test. 

Anaphrodisiac effect. Tincture of the resin, administered intraperitoneally to male mice at a dose of 12.5 mg/kg, produced a significant reduction in mounts and attempted mounts. Other behaviorial activities were unaffected . Angiotensin-converting enzyme inhibition. Ethanol (100%) extract of the dried leaf at a concentration of 333.3 pg/mL produced weak activity, and the water extract was inactive . 

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PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Antibacterial activity. Alcohol extract of black tea, assayed on Salmonella typhi and Salmonella paratyphi A, was active on all strains of Salmonella paratyphi A, and only 42.19% of Salmonella typhi strains were inhibited hy the extract ". Ffot water extract of the dried entire plant and the tannin fraction, on agar plate, were active on Escherichia coli. Pseudomonas aeruginosa, and Staphylococcus aureus. ... 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Acquired immunodeficiency syndrome activity. Coconut oil and monolaurin —a coconut oil byproduct— were administered to 12 women and 3 men who were in the early stage of human immunodeficiency virus infection. Ten patients took different doses of monolaurin, and five patients took coconut oil. It was believed that the treatment would lead to higher CD4 counts and a lower viral load. The trial was abandoned because it received only lukewarm approval from the governmenC s ... 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Allergenic activity. Oleoresin powder, administered externally to adults, was active. Reactions to patch test occurred most commonly in patients who were regularly exposed to the substance, or who already had dermatitis on the fingertips. Previously unexposed patients had few reactions (i.e., no irritant reactions... 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS 5-Hydroxytryptamine inhibition. Ethanol (80%) extract of the dried stem hark, in cell culture at a dose of 10 pg/mL, inhibited the uptake of serotonin (5HT) in rat brainstem neurons L... 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Alkaline phosphatase stimulation. Extract of the leaf, administered orally to adults, was active. Patients with subacute hepatic necrosis had negative workup, except for consumption of 15 tablets of the herbal extract per day for 4 months L Anthelmintic activity. Water and petroleum ether extracts of the dried oleoresin were active on Eimeria tenella in chicken - . Anti-amoebic activity. The resin of Larrea produced inhibitory activity at a concentration of 1 ppm on Entamoeba invadens PZ axenic cultures. The nordihydroguaiaretic acid activity was observed at 10" to 10" concentrations - . 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS 8-Oxodeoxyguanosine level increase. 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Abortifacient effect. Dried seeds, administered intravaginally to pregnant women, were active s . The seedcoat, administered intrauterine to pregnant women at a dose of 350 g/person, was active s . 

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