Abortifacients, effects

Gardner, D.R., Panter, K.E., James, L.F. and Stegelmeier, B.L. (1998). Abortifacient effects of lodgepole pine (Pinus contorta) and common juniper (Juniperus communis) on cattle. Vet. Human Toxicol., 40, 260-263. 

Abortifacient effect. Ethanol (95%) extract of the dried seed, administered by gastric intubation to pregnant mice at doses of 30 mg/animal and 40 mg/kg on days 4-6, was inactive° h Petroleum ether extract of the dried seed, administered subcutaneously... 

Abortifacient effect. The smoke of the dried leaf by pregnant women was act-... 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Abortifacient effect. Dried seeds, administered intravaginally to pregnant women, were active s . The seedcoat, administered intrauterine to pregnant women at a dose of 350 g/person, was active s . 

Abortifacient effect. Ethanol (50%) extract of the dried leaf, administered intra-gastrically to rats at a dose of 200 mg/kg, was... 

These agents are contraindicated in women of childbearing age, unless they are using adequate contraceptive measures, because of uncertain abortifacient effects. They have been used as illegal abortifacients in some countries (47). 

Because the type I interferons produced no adverse effects on embryofetal development and the early abortifacient effect could be predicted based on a measurement of female endocrine changes, the need to conduct additional macaque embryofetal development studies for type I interferons in nonhuman primates was considered unnecessary. Therefore, for the second-generation pegylated versions of the alpha interferons, only hormonal analysis was conducted in macaques. This is the only known example of where mechanistic studies have been accepted in place of developmental studies in accordance with ICH S6 guidance. 

Spilman, C. Roseman, T. Luteolytic and abortifacient effects in rhesus monkeys of silicone vaginal rings containing 15(S) 15-methyl-prostaglandin F2 alpha methyl ester. Contraception 1975, 11, 409-18. 

When used as an abortifacient. the drug often causes liver failure and hemorrhage, leading to death. Pennyroyal is sometimes used with black cohosh to accelerate the abortifacient effect. Coma and death have been reported. Pennyroyal is an example of an herb that has no safe uses. It should not be sold. 

Documented effects Extracts from the fruits and branches have cytotoxic effects on cancer cell Unes in vitro (Jafarian-Dehkordi et al. 2004). Results from experiments with mice indicate that the abortifacient effect of essential oil from Juniperus sabina is related to an implantation inhibiting effect induced by sabinyl acetate (Pages et al. 1996). CycloUgnans, isolated from the leaves, exhibits anti-cancer and anti-viral activity (San Feliciano et al. 1993). 

Phytomedicine preparations in Europe are contraindicated in pregnancy and inflammatory kidney diseases. Prolonged use or overdose may cause kidney damage. Studies using albino rats showed that juniper extract reduced fertility and had an abortifacient effect. ... 

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