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Pharmaceuticals metabolites

Josephs, J.L. Sanders, M. Langish, R.A. Whitney, J. Phillips, J.J. Detection and Characterization of Pharmaceutical Metabolites, Degradants and Impurities by the Application of MS/MS Software Algorithms, in Proceedings of the 51st ASMS Conference on Mass Spectrometry and Allied Topics, Montreal, Canada, June 8-12, 2003. [Pg.400]

The occurrence and fate of pharmaceuticals from various prescription classes and related metabolites and medicinal products for veterinary use in aquatic environments as well as their removal is one of the emerging issues in environmental chemistry.More than 80 different prescribed pharmaceuticals, metabolites, and veterinary drugs have been detected in aquatic environment (e.g., sewage influent and effluent samples, surface and groundwater, and even drinking water), as reported by studies carried out in several European countries. United States, Canada, and Brazil. ... [Pg.954]

The development of IMS has provided an invaluable tool to the field of molecular analysis. Direct analysis of tissues or individual cells offers a mechanism to determine molecular spatial orientation and to evaluate molecular signatures indicative of disease. The technology is commercially available and is widely used as a discovery tool to monitor the spatial distribution of elements, Upids, pharmaceuticals, metabolites, peptides, and proteins and to evaluate molecular activities in biological processes. Assessment of a variety of compounds can be performed in parallel, without the use of isotopic labeling. The potential of IMS has driven methodology and instrumentation developments such as... [Pg.14]

Markers of water pollution show the presence of pollution sources. These include herbicides indicative of agricultural runoff, fecal coliform bacteria that are characteristic of pollution from sewage, and pharmaceuticals, pharmaceutical metabolites, and even caffeine that show contamination by domestic wastewater. [Pg.75]

Retrospective analysis to search for compounds not included in the initial analysis is an attractive feature of TOP MS-based methods. Without additional injection of the samples, it is feasible to investigate the presence of other contaminants or metabolites. This has allowed the detection and identification of pharmaceutical metabolites in wastewater [51]. Obviously, this possibility is also available to other compounds, pesticides included, provided that they are compatible with the sample treatment and LC—MS analysis applied. A detailed comparison of the capabilities of LC—MS using QqQ, TOP, and QTOP for quantification, confirmation, and screening in the field of PRA is given in [45]. [Pg.333]

Hernandez F, Ibtoez M, Gracia-Lor E, Sancho JV. Retrospective LC—QTOF-MS analysis searching for pharmaceutical metabolites in urban wastewater. J Sep Sci 2011 34 3517-26. http //dx.doi.org/10.1002/jssc.201100540. [Pg.336]

Chan, E. C. Y. New, L. S. Yap, C. W. Goh, L. T. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23, 384—394. [Pg.255]

It is possible that some APIs and adjuvants have been present in the environment for years or even decades. A lack of information about the presence of such micro-pollutants is largely due to a shortage of appropriate analytical methods making compounds difficult to detect. The broader availability of LC-MS and LC-MS/MS in particular permits the detection of polar compounds, such as most pharmaceuticals, metabolites and transformation products, that have not previously been amenable to analysis. Today, there is evidence of the occurrence of some 180 different drugs (parent compounds) and many metabolites in sewage treatment plant effluent, surface water and ground water and the number will increase with the development of new analytical methods. [Pg.118]

K. Langford and K. V. Thomas, Input of selected human pharmaceutical metabolites into Norwegian aquatic environment, J. Environ. Monit., 2011, 13, 416 21. [Pg.398]

Dibenz[h,e]azepine-6,11-diones ent-Morphinan nomenclature, 1, 29 Morphinan, 1,2,3,4-tetrahydro-nomenclature, 1, 29 14-a-Morphinan, N-methyl-synthesis, 1, 480 Morphinans nomenclature, 1, 29 as pharmaceuticals, 1, 148 synthesis, 2, 377 Morphine, 2, 512 as analgesic, 1, 167 as metabolite of normorphine, 1, 235 as pharmaceutical, 1, 146, 147, 148 synthesis, 1, 480 Morphine alkaloids structure, 4, 534 Morphin-7-en nomenclature, 1, 29 Morphinone, dihydro-as pharmaceutical, 1, 147 Morpholine — see also 1,4-Oxazine, tetrahydrocarcinogenicity, 1, 229 corrosion inhibitor, 1, 409 metabolism, 1, 226 nomenclature, 3, 996 structure, 2, 5 synthesis, 2, 89 Morpholine, 4-aciyloyl-polymers, 1, 291 Morpholine, alkenyl-polymers, 1, 291... [Pg.704]

Drugs with endocrinological functions or side-effects are common, but oestrogenic hormones in oral contraceptives are particularly widely used. Pharmaceuticals and their metabolites eventually find their way into the environment, predominantly via excretion into sewage. ... [Pg.15]

Diclofenac is an exceedingly potent COX inhibitor slightly more efficacious against COX-2 than COX-1. Its absorption from the gastrointestinal tract varies according to the type of pharmaceutical formulation used. The oral bioavailability is only 30-80% due to a first-pass effect. Diclofenac is rapidly metabolised (hydroxylation and conjugation) and has a plasma half-life of 1.5 h. The metabolites are excreted renally and via the bile. [Pg.875]

An example of a separation primarily based on polar interactions using silica gel as the stationary phase is shown in figure 10. The macro-cyclic tricothecane derivatives are secondary metabolites of the soil fungi Myrothecium Verrucaia. They exhibit antibiotic, antifungal and cytostatic activity and, consequently, their analysis is of interest to the pharmaceutical industry. The column used was 25 cm long, 4.6 mm in diameter and packed with silica gel particles 5 p in diameter which should give approximately 25,000 theoretical plates if operated at the optimum velocity. The flow rate was 1.5 ml/min, and as the retention time of the last peak was about 40 minutes, the retention volume of the last peak would be about 60 ml. [Pg.305]

Organophosphate flame retardants and plasticisers Perfluorinated compounds Pharmaceuticals and personal care products Polar pesticides and their degradation/transformation products Surfactants and their metabolites... [Pg.200]

Quintana JB, Weiss S, Reemtsma T (2005) Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res 39 2654-2664... [Pg.226]

The application areas for LC-MS, as will be illustrated later, are diverse, encompassing both qualitative and quantitative determinations of both high-and low-molecular-weight materials, including synthetic polymers, biopolymers, environmental pollutants, pharmaceutical compounds (drugs and their metabolites) and natural products. In essence, it is used for any compounds which are found in complex matrices for which HPLC is the separation method of choice and where the mass spectrometer provides the necessary selectivity and sensitivity to provide quantitative information and/or it provides structural information that cannot be obtained by using other detectors. [Pg.187]


See other pages where Pharmaceuticals metabolites is mentioned: [Pg.153]    [Pg.557]    [Pg.1]    [Pg.3]    [Pg.131]    [Pg.329]    [Pg.331]    [Pg.1310]    [Pg.2321]    [Pg.451]    [Pg.259]    [Pg.102]    [Pg.136]    [Pg.160]    [Pg.163]    [Pg.404]    [Pg.153]    [Pg.557]    [Pg.1]    [Pg.3]    [Pg.131]    [Pg.329]    [Pg.331]    [Pg.1310]    [Pg.2321]    [Pg.451]    [Pg.259]    [Pg.102]    [Pg.136]    [Pg.160]    [Pg.163]    [Pg.404]    [Pg.1]    [Pg.517]    [Pg.575]    [Pg.710]    [Pg.710]    [Pg.2134]    [Pg.55]    [Pg.58]    [Pg.72]    [Pg.196]    [Pg.39]    [Pg.915]    [Pg.130]    [Pg.201]    [Pg.202]    [Pg.218]    [Pg.75]    [Pg.179]    [Pg.810]   
See also in sourсe #XX -- [ Pg.64 ]




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