Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Pharmaceutical capsules

Uses of gelatin are based on its combination of properties reversible gel-to-sol transition of aqueous solution viscosity of warm aqueous solutions abUity to act as a protective coUoid water permeabUity and insolubUity in cold water, but complete solubUity in hot water. It is also nutritious. These properties are utilized in the food, pharmaceutical, and photographic industries. In addition, gelatin forms strong, uniform, clear, moderately flexible coatings which readily sweU and absorb water and are ideal for the manufacture of photographic films and pharmaceutical capsules. [Pg.206]

Pharmaceuticals Thiazides Industrial process streams Pharmaceutical capsules 5 X 10 9 mol L1 0.06 pmol (hydroflumethiazide),... [Pg.222]

Micke, G. A., Fujiya, N. M., Tonin, F. G., de Oliveira Costa, A. C., and Tavares, M. F. M. (2006). Method development and validation for isoflavones in soy germ pharmaceutical capsules using micellar electrokinetic chromatography. /. Pharm. Biomed. Anal. 41(5), 1625—1632. [Pg.167]

Fluorescence from pharmaceutical capsule shells and tablet coatings has hindered measurement of their composition by Raman spectroscopy. By switching from the conventional backscattering mode to a transmission mode, Matousek et al. demonstrated that fluorescence could be eliminated in many instances [8]. Backscattering- and transmission-mode Raman spectra of several samples are shown in Figure 7.5. Each spectrum was acquired in 10s with 80mW 830-mn laser power. Matousek et al. also speculate that signal acquisition times could be relatively easily shortened to well below 0.1 s when the transmission mode is combined with optimized optics [8]. [Pg.210]

Figure 7.6 Raman spectra of a pharmaceutical capsule using different measurement configurations. (Bottom) Capsule alone, (a) Commercial backscattering system with small sample area (b) Commercial backscattering system defocused to make sample area slightly larger (c) WAI backscattering probe (d) Transmission mode. (Top) Capsule contents. Reprinted from Eliasson et al. (2008) [41] with permission from Elsevier. Figure 7.6 Raman spectra of a pharmaceutical capsule using different measurement configurations. (Bottom) Capsule alone, (a) Commercial backscattering system with small sample area (b) Commercial backscattering system defocused to make sample area slightly larger (c) WAI backscattering probe (d) Transmission mode. (Top) Capsule contents. Reprinted from Eliasson et al. (2008) [41] with permission from Elsevier.
P. Matousek and A.W. Parker, Non-invasive probing of pharmaceutical capsules using transmission Raman spectroscopy, J. Raman Spectrosc., 38, 563-567 (2007). [Pg.231]

C. Eliasson, N.A. Macleod, L.C. Jayes, F.C. Clarke, S.V. Hammond, M.R. Smith, and P. Matousek, Non-invasive quantitative assessment of the content of pharmaceutical capsules using hansmission Raman spectroscopy, J. Pharm. Biomed. Anal., 47, 221-229 (2008). [Pg.232]

Podczeck F. Powder, granule and pellet properties for filling of two-piece hard capsules, Chapter 5 in Pharmaceutical Capsules, 2nd ed. In Podczeck F, Jones BE, eds. London Pharmaceutical Press, 2004, 108. [Pg.433]

Fig. 3.12. Non-invasive Raman spectra of pharmaceutical capsules. The spectra were obtained using a laboratory instrument configured in the transmission Raman geometry and a standard commercial Raman microscope (Renishaw) in conventional backscattering geometry. The Raman spectra of an empty capsule shell (lowest trace) and the capsule content itself (top trace, the capsule content was transferred into an optical cell) are shown for comparison. The dashed lines indicate the principal Raman bands of the capsule and of the API (this figure was published in [65], Copyright Elsevier (2008))... Fig. 3.12. Non-invasive Raman spectra of pharmaceutical capsules. The spectra were obtained using a laboratory instrument configured in the transmission Raman geometry and a standard commercial Raman microscope (Renishaw) in conventional backscattering geometry. The Raman spectra of an empty capsule shell (lowest trace) and the capsule content itself (top trace, the capsule content was transferred into an optical cell) are shown for comparison. The dashed lines indicate the principal Raman bands of the capsule and of the API (this figure was published in [65], Copyright Elsevier (2008))...
Ozaltin and Kocer [28] used a derivative spectroscopic method for the determination of omeprazole in pharmaceuticals. Capsule contents were powdered and a sample equivalent to one capsule content was sonicated with 10 ml ethanol, diluted to 100 ml with 0.1 M borate buffer of pH 10 and further diluted as necessary. Spectra were recorded at 50 nm/min with a 3-nm slit width second-order derivative curves were obtained for 200-400 nm using A2 = 31.5 and N = 9. The calibration graph for peak-to-peak measurements between 303 and 310 nm were linear for 0.2-40 yg/ml omeprazole and the RSDs were 1.09-4.55%. Mean recovery was 100.7%. Result agreed with those obtained by polarography. [Pg.206]

Another proposed process employed injection molding in which starch and limited amounts of plasticizing water are heated under pressure to temperatures above the Tg and Tm to transform the native starch into a homogenous, destructured, thermoplastic melt. The process melt is then cooled to below the Tg of the system before pressure release to maintain the moisture content. Additives include natural and synthetic polymers, plasticizers and lubricants.136-139 159 160 The technology has been used to prepare pharmaceutical capsules and shaped objects, such as disposable cutlery, straws and pens. [Pg.641]

Podczeck F, Jones BE, ed. Pharmaceutical Capsules, 2nd edn. London Pharmaceutical Press, 2004. [Pg.297]

A similar need exists in the quality control of pharmaceutical capsules and coated tablets, where their bulk content may be required. Although in many applications conventional Raman spectroscopy has proven to be very effective, in some cases the Raman signal or interfering fluorescence emanating from the capsule shell or tablet coating can severely reduce the sensitivity of conventional Raman spectroscopy. [Pg.421]

Figure 12.14 Comparison of performance of the conventional backscattering and transmission Raman geometries in probing various pharmaceutical capsules. The acquisition times were 10 s, unless indicated otherwise, with a laser power of 80mW. designates Raman band originating from capsule shell. Reprinted with permission from Ref [37] 2007, John Wiley Sons. Figure 12.14 Comparison of performance of the conventional backscattering and transmission Raman geometries in probing various pharmaceutical capsules. The acquisition times were 10 s, unless indicated otherwise, with a laser power of 80mW. designates Raman band originating from capsule shell. Reprinted with permission from Ref [37] 2007, John Wiley Sons.
Capsules manufactured for use on automatic filling machines, which covers almost all pharmaceutical capsules, have locking devices moulded into the side of the capsule (Figure 11.29). There are two locking positions, a pre-lock to prevent premature opening prior to the... [Pg.444]

Podczeck, R, Jones, B.E. Pharmaceutical Capsules, Pharmaceutical Press London, U.K., 2004. [Pg.530]

Kerosene Methyl oleate Silica, hydrated Soybean (Glycine soja) oil Vegetable oil carrier, pharmaceutical capsules Glyceryl caprylate carrier, pharmaceutical coatings Glyceryl caprate... [Pg.4935]

Stearamide MEA-stearate Stearyl methacrylate coating agent, pharmaceutical capsules Sucrose... [Pg.4969]


See other pages where Pharmaceutical capsules is mentioned: [Pg.743]    [Pg.207]    [Pg.418]    [Pg.690]    [Pg.862]    [Pg.210]    [Pg.207]    [Pg.743]    [Pg.55]    [Pg.65]    [Pg.195]    [Pg.57]    [Pg.417]    [Pg.417]    [Pg.3159]    [Pg.356]    [Pg.421]    [Pg.126]    [Pg.444]    [Pg.120]    [Pg.264]    [Pg.103]    [Pg.309]    [Pg.1113]    [Pg.1724]   
See also in sourсe #XX -- [ Pg.376 ]

See also in sourсe #XX -- [ Pg.376 ]




SEARCH



Quality pharmaceutical capsule

© 2024 chempedia.info