Pharmaceutical industry trends

S. Gorog, Steroid analysis in pharmaceutical industry, Trends Anal. Chem., 3 157-161 (1984). 

Lyall A. Bioinformatics in the pharmaceutical industry. Trends Biotechnol 1996 14(8) 308-312. 

Ibid., pp. 109-112 Heinz Redwood, The Pharmaceutical Industry Trends, Problems, and Achievements (Felixstowe, England Oldwicks Press, 1987), pp. 26-30, for the new technologies. Redwood s dates for the extractive chemical wave are 1917-1932. See also Peter Temin, Taking Your Medicine Drug Regulation in the United States (Cambridge, MA Harvard University Press, 1980), pp. 4, 59, 63-64, 221. 

Redwood, H., The Pharmaceutical Industry Trends, Problems, and Achievements (Suffolk, United Kingdom Oldwicks Press, 1988). 

A recent trend in the pharmaceutical industry has been to harness the intrinsic tissue-protective properties of NO for improving the gastric tolerance of nonsteroidal antiinflammatory drugs (NS AIDs). This trend has led to the synthesis of hybrid, chimeric molecules containing an NSAID or aspirin moiety and a NO-donor functionality [153, 154]. One such hybrid is a NO-releasing derivative of aspirin, NCX-4016. In a doubleblind, randomized, placebo-controlled gastrointestinal safety assessment in healthy subjects, NCX-4016 (400 or 800 mg twice daily for 7 days) acted like aspirin as an inhibitor of arachidonic acid-induced platelet aggregation in vitro [155]. Whether... 

Even with the progression away from govemmenf and regulation, fhe effecf fhis trend on the pharmaceutical industry remains substantial. The loosening of Occupational Safety... 

Sample preparation (SP) is generally not given adequate attention in discussions of pharmaceutical analysis even though its proper execution is of paramount importance in achieving fast and accurate quantification (see Chapter 5). Non-robust SP procedures, poor techniques, or incomplete extraction are the major causes of out-of-trend and out-of-specification results. The common SP techniques have been reviewed with a strong focus on tablets or capsules, as they are the primary products of the pharmaceutical industry. Detailed descriptions of SP methods for assays and impurity testing are provided with selected case studies of single- and multi-component products. 

Theoretical calculations can also provide physicochemical data, which can be used as an input for 3D-QSAR correlation studies [134,141]. There is a current trend in the area of lead-finding in the pharmaceutical industry to use calculations to set up computer search profiles to be used in the screening of large structural databases, such as the chemical suppliers databases and the internal company databases. 

Rather than comparing these two series directly, Scherer computes the deviations of each series from its best-fitting linear trend. He finds a high correlation between these two sets of deviations and concludes that the similarity of trend deviation patterns suggest that there was indeed cyclical co-movement in pharmaceutical industry growth margins and R D... 

---