Peroxisome proliferator activator receptor-/ PPAR

A peroxisome proliferator-activated receptor (PPAR) binding site was identified in the murine FATP1 promoter. Several reports have shown a positive regulation of mouse FATPs by ligands that activate PPAR-a, PPAR-y, or PPAR-y/RXR heterodimers. [Pg.498]

Peroxisome Proliferator-Activated Receptor (PPARs) HMG-CoA Reductase Inhibitors... [Pg.502]

Peroxisome Proliferator-Activated Receptors (PPARs) Diabetes Mellitus... [Pg.637]

Peraza MA, Burdick AD, Marin HE et al (2006) The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR). Toxicol Sci 90 269-295... [Pg.893]

Di- and mono-esters of phthalic acid, an ortho-dicarboxylic acid derivative of benzene. These compounds are widely used as industrial plasticizers to coat polyvinylchloride surfaces of plastics used in food packaging and medical devices (iv drip bags, blood storage bags, etc.) and are common environmental contaminants. Several phthalate mono-esters are peroxisome proliferator chemicals and can activate the peroxisome proliferator-activated receptor PPAR. [Pg.976]

Peroxisome-proliferator activated receptors (PPARs) are lipid-activated transcription factors exerting several functions in development and metabolism. PPARa is implicated in the regulation of lipid metabolism, lipoprotein synthesis, and inflammatory response in liver and other tissues. [Pg.468]

Peroxisome Proliferator activated receptor (PPAR-GAMMA-2) Insulin Variation of insulin efficacy in the treatment of diabetes (93) Susceptibility to type II diabetes (93)... [Pg.66]

Peroxisome proliferator-activated receptors (PPARs) PPREs Regulate multiple aspects of lipid metabolism Activated by fibrates and thiazolidinediones Zinc finger... [Pg.72]

Peroxisome proliferator-activated receptors (PPARs) are transcription factors that bind to DNA response elements (PPREs) and control multiple aspects of lipid metabolism. Individual members of this family of zinc-finger proteins are activated by a variety of natural and xenobiotic dgands, including ... [Pg.73]

Ajulemic acid (77) Cannabinoid CP 7075 (IP 751, ajulemic acid, CT-3) (synthetic version) Neurological (neuropathic pain) Suppresses IL-lp and mahix metalloproteinases (MMPs) through a peroxisome proliferator-activated receptor (PPAR) y-mediated mechanism Phase I Cervelo Pharmaceuticals 615-618... [Pg.65]

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) AGONISTS FOR TYPE 2... [Pg.117]

Sundvold H, Lien S 2001 Identification of a novel peroxisome proliferator-activated receptor (PPAR) gamma promoter in man and transactivation by the nuclear receptor RORalphal. Biochem Biophys Res Commun 287 383-390... [Pg.99]

The 3,4-dihydro-22/-l,3-benzoxazin-4-one derivative DRF-2519 587, bearing a 2,4-thiazolidinedione moiety in the side chain attached to the nitrogen atom, proved to be an activator of the a- and y-types of the peroxisome proliferator-activated receptors (PPAR-a and -7), which endowed it with antidiabetic and hypolipidemic potential. Compound 587 demonstrated significant plasma glucose-, insulin-, and lipid-lowering activity in mice and improvement in lipid parameters in fat-fed rats <2006BMC584>. [Pg.449]

Jow, L. Mukheijee, R. (1995) The human peroxisome proliferator-activated receptor (PPAR) subtype NUCl represses the activation of hPPAR a and thyroid hormone receptors. J. biol. Ghent., 270, 3836-3840... [Pg.135]

Lee, J., Richburg, J.H., Younkin, S.C. Boekelheide, K. (1997) The Fas system is a key regulator of germ cell apoptosis in the testes. Endocrinology, 128, 2081-2088 Lewis, D.F.V Lake, B.G. (1993) Interaction of some peroxisome prolrferators with the mouse liver peroxisome proliferator-activated receptor (PPAR) a molecular modelling and quantitative stracture-activity relationship (QSAR) study. Xenobiotica, 23, 79-96 Lewis, L.M., Flechtner, T.W., Kerkay, J., Pearson, K.H. Nakamoto, S. (1978) Bis(2-ethyl-hexyl) phthalate concentrations in the serum of hemodialysis patients. Clin. Chem., 24, 741-746... [Pg.137]

Although prostanoids can activate peroxisome proliferator-activated receptors (PPARs) if added in sufficient concentration in vitro, it remains questionable whether these compounds attain concentrations sufficient to function as endogenous nuclear-receptor ligands in vivo. [Pg.404]

Research has now established that the peroxisome proliferators act on a receptor, called the peroxisome proliferator-activated receptor (PPAR), discovered in 1990. There are now known to be three receptors PPARa, PPARS, and PPARy. These are parts of the nuclear hormone super family. The PPARs are ligand-dependent transcription factors, which have different functions and tissue locations. [Pg.305]

Proteins in a family of ligand-activated transcription factors, the peroxisome proliferator-activated receptors (PPARs), respond to changes in dietary lipid by... [Pg.915]

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