Peroxisome proliferator-activated PPAR

Sulindac is a racemic sulfoxide. Its deoxygenated metabolite (i.e., a sulfide) induces apoptosis, probably through inhibition of PPAR (Peroxisome Proliferator-Activated Receptor) It is probably the reason why suhndac seems to protect against colorectal cancers. Indeed, sulindac inhibits colorectal tumor cell growth. One other metabolite of sulindac, the sulfone exulind, is an inductor of apoptosis, and is currently in Phase III clinical trials for treatment of tumors (Figure 8.3). [Pg.317]

PPAR Peroxisome proliferator-activated receptor VLDL Very-low-density lipoproteins... [Pg.776]

PPAR peroxisome proliferator-activated receptor. Receptor involved in the induction of peroxisomal enzymes other responses to certain chemicals. [Pg.419]

LDL, low-density lipoprotein ATP, adenosine triphosphate TNF, tumor necrosis factor HMG-CoA, 3-hydroxy-3-methyl-glutaryl-coenzyme A PPAR, peroxisome proliferator-activated receptor. [Pg.94]

ER Estrogen Receptor, AR Androgen Receptor, GR Glucocorticoid Receptor, TR Thyroid Receptor, RAR Retinoic Acid Receptor, RXR Retinoie X Receptor, PR Progesterone Receptor, VDR Vitamin D Receptor, PPAR Peroxisome Proliferator-Activated Receptor, PXR Pregnane X Receptor, ROR Retinoic Acid-Related Orphan Receptor, NHF-4 Hepatocyte Nuclear Eactor 4, ERR Estrogen-Related Receptor... [Pg.2]

PPAR peroxisome proliferator-activated receptor SMZ sulfamethoxazole... [Pg.949]

PPAR peroxisome proliferator-activated zVAD-fmk benzyloxycarbonyl-Val-Ala-Asp-... [Pg.577]

Fig. 4.4 HRE structure of the RXR heterodimer. Shown isthe consensus sequence of the HREs of the RXR heterodimers (see Fig. 4.7) and the different possible arrangements of the hexameric half-site sequences. The hexamers can be arranged palindromically as inverted repeats (a), as everted repeats (b), or as direct repeats (c). n indicates the number of base pairs that lie between the two hexamers. RXR receptor for 9-cis-retinoic acid RAR receptor for all-trans retinoic acid T3R receptor for the T3 hormone PPAR peroxisome proliferator activated receptor VDR receptor for vitamin D3.

Abbreviations AA arachidonic acid AFA alpha-linolenic acid AP-1 activator protein 1 COX cyclooxygenase DFIA docosahexaenoic acid EPA eicosapentaenoic acid IF interleukin FA linoleic acid FOX lipoxygenase EPS lipopolysaccaride FT leukotriene NF-kB nuclear factor-kappa B, PG prostaglandin PPARs peroxisome proliferator-activated receptors PUFA polyunsaturated fatty acids, RvEl resolvin El, TNFa tumor necrosis factor alpha, TX thromboxane... [Pg.133]

NDA-New drug application ANDA-Abbreviated new drug application CV-cardiovascular PPAR-Peroxisome Proliferator Activator Receptor MMV-Medicines for Malaria Venture GAVI-Global Alliance for Vaccines and Immunization EMEA-European Medicinal Evaluation Agency... [Pg.167]

Improvement of insulin action in T2D subjects must therefore be a primary aim for the normalisation of blood glucose values, mainly in the postprandial state. Normalisation of insulin sensitivity in peripheral tissues in T2D has, however, never been the main objective, as we possessed no tools carrying the potential for reaching this objective. However, the recently discovered PPAR (peroxisome proliferator-activated receptor) gamma agonists, namely gUtazones, carry this potential. [Pg.101]

The thiazolidinediones (e.g. rosiglitazone) appear to decrease insulin resistance through activation of gamma-PPAR (peroxisome proliferator-activated receptor). They are used in type 2 diabetes. [Pg.468]

The abbreviations used are HMG-CoA, 3-hydroxy-3-melhylglutaryl-CoA CAT, chloramphenicol acetyltransferase PPAR, peroxisome proliferator-activated receptor PPRE, peroxisome proliferator-responsive element NRRE, nuclear receptor responsive element RXR, retinoid X receptor hRXRa, human 9-cis-retinoic acid receptor a mPPARa, mouse peroxisome proliferator-activated receptor a COUP-TP, chicken ovalbumin upstream-promoter transcription factor, HNF-4, hepatocyte nuclear factor 4 EMSA, electrophoretic mobility shift analysis tk, thymidine kinase NEFA, nonesterified fatty acids... [Pg.84]

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