Peripheral vascular disease derivatives

Dopamine agonists are contraindicated in patients with a history of psychotic illness or recent myocardial infarction, or with active peptic ulceration. The ergot-derived agonists are best avoided in patients with peripheral vascular disease. 

Cl, confidence interval Ml, myocardial infarction PVD, peripheral vascular disease TIA, transient ischemic attack. Hazard ratios derived from the model are used for the scoring system. The score for the five-year risk of stroke is the product the individual scores for each of the risk factors present. The score is converted into a risk with a graph. Source. Rothwell et at. (2005). 

Ticlopidine is a thienopyridine derivative with potent antiplatelet activity associated with inhibition of ADP-induced platelet aggregation. It was first used in Europe in 1978 in the secondary prevention of stroke and coronary events, the treatment of peripheral vascular disease, and after vascular stent placement. However, the use of ticlopidine has been progressively restricted in some countries because of its serious adverse effects. It has largely been superseded by clopidogrel. 

Iduridin ibacitabine. ifenprodil [inn, usan] (Ifenprodil tartrate [jan]) is a benzylpiperidinohydroxyphenylpropanol derivative, an a-ADRENOCEPTOR ANTAGONIST that iS a VASODILATOR. It was formerly used in treating peripheral vascular disease. It is also a GLUTAMATE RECEPTOR ANTAGONIST (NMDA) and is an experimental NEUROPROTECTIVE AGENT. 

Nicergoiine is an ergot derivative used to treat symptoms of mental deterioration associated with cerebrovascular insufficiency as well as in peripheral vascular disease. Fumagalli et al. (1992) reported an airborne dermatitis on the face of a chemical technician who had been exposed to powders containing this drug and its chemical intermediates during their production. 

Epoetin delta differs from the other erythropoietin derivatives in that it is produced in a human cell line using gene-activation technology. It has been approved in Europe but not in the USA for the treatment of anemia associated with chronic kidney disease. In patients with cancer and anemia who were given epoetin delta, possible treatment-related serious adverse events were hypertension, increased serum creatinine, and peripheral vascular disease [99 ]. There was a correlation with higher doses, suggesting that a dose of 150 lU/kg would be most appropriate to start with for this indication. 

Rufaihah, A.J., Huang, N.E., lame, S., Lee, J.C., Nguyen, H.N., Byers, B., De, A., Okogbaa, J., Rollins, M., Reijo-Pera, R. Endothelial cells derived from human ipscs increase capillary density and improve perfusion in a mouse model of peripheral arterial disease. Arteriosclerosis, Thrombosis And Vascular Biology 31, e72-e79 (2011)... 

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