Peptococcus

Fig. 2. Protein backbone representations of (a) the 2[4Fe-4S] ferredoxin from Peptococcus aerogenes, (b) the proposed structure of the FA/FB-binding protein of PSl based on the 4 A crystsd structure (25), and (c) the [3Fe-4S][4Fe-4S] ferredoxin from Sulfolo-bus acidocaldarius. Ligands to clusters Fa and Fb, important residues as well as the loop extension (see text) EU e highlighted in darker gray.

Fig. 3. Sequence comparison of the FA/FB-binding subunits of PSl from tobacco and the RC of green sulfur bacteria with that of the 2[4Fe-4S] ferredoxin from Peptococcus aerogenes. Cysteine ligands to the right-hand cluster in the three structures of Fig. 2 (i.e., cluster Fb for the case of the FA/FB-protein) are marked by open boxes Emd residues ligating the left-hand cluster by hatched boxes.

The anaerobe Peptococcus (Micrococcus) aerogenes had a dehydrogenase that carried out specific hydroxylation at the 6-positions of 2- and 8-hydroxypurine, and was therefore distinct from xanthine dehydrogenase from which it could be separated (Woolfolk et al. 1970). It was also able to carry out dismutation of 2-hydroxypurine to xanthine (2,6-dihydroxypurine) and hypoxanthine (6-hydroxypurine). 

Figure 26 X-Ray structure of the active site of the 8Fe ferredoxin of Peptococcus aerogenes...

Arrangement is according to the atomic number of the reacting element. Currently Peptococcus aerogenes. 

Figure 3. Amino add sequence of Peptococcus aerogenes ferredoxin.

Lincosamides (lincomycin and clindamycin) are representatives of a very small group of drugs synthesized up of an amino acid bound to an amino sugar. Lincosamides bind with the 50 S ribosomal subunit of bacteria and inhibit protein synthesis. They also inhibit pep-tidyltransferase action. Lincosamides are bacteriostatic antibiotics however, when they reach a certain level in the plasma, they also exhibit bactericidal action against some bacteria. Lincosamides are highly active against anaerobic infections such as Peptococcus, Peptostreptococcus, Actinomyces, Propionibacterium, and Clostridium fringens, a few types of Peptococcus and Clostridium. 

Intra-abdominal Infections - Enterococcus faecalis, S. aureus (penicillinase-producing), Staphylococcus epidermidis, E. coli, Klebsiella sp., Enterobacter sp., Proteus sp., M. morganii, P. aeruginosa, Citrobactersp., Clostridium sp., Bacteroides sp. including Bacteroides fragilis, Fusobacterium sp. Peptococcus sp., Peptostreptococcus sp., Eubacterium sp., Proplonibacterium sp.. Bifidobacterium sp. 

More severe infections - More severe infections, particularly those caused by Bacteroides fragilis, Peptococcus sp. or Clostridium sp. other than C. perfringens. 1.2 to 2.7 g/day in 2 to 4 equal doses. 

Peptococcus sp. Peptostreptococcus Microaerophilic streptococci Clostridium perfringens Clostridium tetani Veillonella sp. 

Skin and skin structure infections - Caused by Bacteroides sp. including the B. fragilis group, Clostridium sp., Peptococcus sp., Peptostreptococcus niger, and Fusobacterium sp. 

Adman, E. T., Watenpaugh, K. D., and Jensen, L. H. (1975). NH---S hydrogen bonds in Peptococcus aerogenes ferrodoxin, Clostridium pasteurianum rubredoxin and Chromatium high potential iron protein. Proc. Natl. Acad. Sci. U.S.A. 72,4854—4858. 

Fe-xS] ferredoxins, 33 54-55 rubredoxin, 33 44-51 hydrophobic effect, 33 60-62 significance, 33 40-44 metal complexes of, 7 218-220 model complexes, catalysis by, 33 61-62 Peptococcus aerogenes ferredoxin, structure, 38 242, 244-245... 

Gram-positive (Clostridia, Peptococcus, Actinomyces, Peptostreptococcus) Penicillin, clindamycin Vancomycin, carbapenem,6 chloramphenicol... 

Gram-positive cocci. Leuconostoc, Micrococcus, Peptococcus, Staphylococcus (S. aureus, boils, infections), Streptococcus (S. pyogenes, scarlet fever, throat infections, S. pneumoniae, pneumonia)... 

The bacterial ferredoxins from Peptococcus, Clostridium (Fig. 16-16B),267/268 Desulfovibrio, and other anaerobes each contain two Fe4S4 clusters with essentially the same structure as that of the Chromatium HIPIP.267 269 Each cluster can accept one electron. 

From the biological area, iron-sulfur clusters in biomolecules such as rubredoxin mononuclear Fe-S clusters (Rao et at., 1972), plant-type ferredoxin 2Fe-2S clusters (Johnson, 1975) and bacterial-type ferredoxin 4Fe-2S clusters (Thompson et at., 1974) are readily distinguished from one another by their Mossbauer spectra. The temperature dependence of relaxation effects can provide information about the types of internuclear interaction and can even lead to estimates of the distance between paramagnetic sites, for example, the two 4Fe-4S clusters in ferredoxin in Peptococcus aerogenes (Adman etal., 1973). 

Europine (165) Peptococcus heliotrinreducans (7a-Hydroxy-l-methylene-8a-pyrrolizidine) (173) (-) 166... 

Both the microorganisms mentioned above metabolized lasiocarpine (162), the gram-negative coccus leading to unidentified product(s) 165), and Peptococcus heliotrinreducans producing the 1-methylene derivative 175 166). 

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