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Peptides as Biomarkers

Orioli, M., Aldini, G., Benfatto, M. C., Facini, R. M., and Carini, M. (2007). HNE Michael adducts to histidine and histidine-containing peptides as biomarkers of lipid-derived carbonyl stress in urines LC-MS/MS profiling in Zucker obese rats. Anal. Biochem. 79, 9174-9184. [Pg.147]

Rapid Profiling of Human Pathogenic Bacteria and Antibiotic Resistance Employing Specific Tryptic Peptides as Biomarkers... [Pg.275]

Taking advantage of the methodologies referred in the preceding text, the systematic study of all salivary secretory peptidome components, PTMs, and protein-peptide complexes has been the initial key step of saliva basic knowledge for further application to clinical applications (52-56). Besides their potential use as biomarkers, salivary peptides have been studied so far mainly in relation to their function in the oral cavity, for example, in the modulation of enamel mineralization (57,58), diurnal variations (45), age-dependent modifications (11,27,59), or diet influence (60). [Pg.228]

Cataliotti A, Malatino LS, Jougasaki M, Zoccali C, Castellino P, Giacone G, et al. Circulating natriuretic peptide concentrations in patients with end-stage renal disease role of brain natriuretic peptide as a biomarker for ventricular remodeling. Mayo Clin Proc 2001 76 1111-9. [Pg.1662]

Vorovich EE, Chuai S, Ii M, Averna J, Marwin V, Wolfe D, Reilly MP, Cappola TP (2008) Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure. Am Heart J 155(6) 992-997. doi 10.1016/j.ahj.2008.01.007... [Pg.477]

Recombinant antibodies offer a number of potential benefits over monoclonal antibodies, as they can be derived from almost any animal in which the immunoglobulin DNA sequences have been described. This aspect of recombinant antibody technology is of particular benefit, as biomarkers for disease diagnosis are often proteins and peptides, which are highly conserved in animals closely related to humans. This can be a particular problem in mice, which frequently develop tolerance for the immunizing antigen, rendering traditional monoclonal antibody development to... [Pg.211]

Engle, S.K., Watson, D.E. (2016). Natriuretic peptides as cardiovascular safety biomarkers in rats comparison with blood pressure, heart rate, and heart weight. Toxicol. Sci. 149(2) 458 72. [Pg.394]

Inoue K, Garner C, Ackermann BL, Oe T, Blair lA. Liquid chromatography/tandem mass spectrometry characterization of oxidized amyloid beta peptides as potential biomarkers of Alzheimer s disease. Rapid Commun Mass Spectrom 2006 20 911—918. [Pg.676]

Set-up and publish lists of organism-specific biomarkers (proteins or peptides) as a community resource for quick and reliable identification... [Pg.295]

All four of the proteomic technologies mentioned above (2D-PAGE, HPLC, MS, and protein arrays) are dependent on the use of bioinformatics as a tool for data mining and elucidation. Often, MS runs generate lists of thousands of potential peptide biomarkers, and only with the help of dedicated software tools can the data be analyzed. Computer searches involving databanks of peptides and proteins are used to compare the lists of masses of the proteolytic peptides to theoretical proteolytic products. Matches between the observed mass and the calculated mass can serve as a way of identifying proteins of interest [28-32],... [Pg.165]

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