Heart weight

In this study, beagle dogs were also treated with the compound in the diet at doses of 0, 4, 13, or 38 mg/kg/day for 14 days (Hart 1976). No deviation in heart weight or abnormal histopathological findings were reported in beagles that received diisopropyl methylphosphonate in the diet at doses of 0,... 

Cardiovascular Heart weight, wall thickness, left ventricular (LV) and right ventricular (RV) end-diastolic and end-systolic lumen volumes (EDV and ESV, respectively), cardiac output (CO), heart rate, and LV diastolic filling pressure Magnetic resonance imaging Dog Opie189... 

Klintschar, M., StiUer, D., Schwaiger, P., and Kleiber, M. (2005) DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes association with unexpected death from acute myocardial infarction and increased heart weight. Forensic Sci. Int. 153, 142-146. 

Limited information is available regarding cardiovascular effects in animals. No alterations in relative heart weight were observed in rats or guinea pigs exposed to 1,4-dichlorobenzene at an air concentration of 173 ppm, 7 hours a day, 5 days a week for up to 12 exposures (Hollingsworth et al. 1956). Similar... 

A significant increase in absolute heart weight was reported in male and female rats exposed to... 

There were no histopathological changes and no change in the relative heart weight in rats following exposure by gavage to single doses of up to 12,000 mg/kg kerosene or 12,150 mg/kg Deobase (Muralidhara et al. 1982). Data for Deobase are limited because effects were reported for only one dose. 

Cardiovascular Effects. Hexachlorobutadiene did not alter heart weights or cause treatment-related lesions of the heart in rats or mice exposed for intermediate durations (90-148 days) at dose levels of 19.2-20 mg/kg/day (NTP 1991 Schwetz et al. 1977 Yang et al. 1989) and 100 mg/kg/day (Kociba et al. 1971) or after lifetime exposure at dose levels of 20 mg/kg/day (Kociba et al. 1977a). 

Changes in heart weight were observed in animals after longer term oral exposure to nickel, but the significance of these effects is not known (Ambrose et al. 1976 American Biogenics Corporation 1988). Parenteral studies in dogs indicate that exposure to 0.01-10 mg nickel/kg/day results in coronary... 

Cardiovascular Effects. Altered heart rate has been observed in humans following oral exposure to aluminum phosphide (Chopra et al. 1986 Khosla et al. 1988) however, the cardiotoxicity probably resulted from exposure to phosphine gas, rapidly released from aluminum phosphide in the mouth and stomach, rather than the aluminum. Oral exposure in rodents and dogs to other forms of aluminum has not been shown to affect heart weight or histology. 

Cardiovascular Effects. Cardiovascular effects have been detected in animals following acute-, intermediate-, and chronic-duration oral exposure to 2,3,7,8-TCDD. These included changes in heart weight, pathophysiological effects, and degenerative changes. However, exposures at or near a lethal dose were required to elicit these effects. 

Decreased absolute heart weight was reported in minks 28 days after a single oral dose of 5 g/kg, but not at 2.5 g/kg (Hochstein et al. 1988). A reduction of absolute heart weight which is attributed to weight loss was also found in monkeys at 70 g/kg (relative heart weight was increased) (McConnell et al. 1978a). Histological examinations of the heart were normal in the monkeys. This examination was not performed in minks. Doses in both species were near the lethal dose. 

In other studies with rats, intermediate and chronic oral exposure to barium chloride and barium acetate in drinking water have not been associated with any changes in heart weight or with any gross or microscopic lesions of the heart (Schroeder and Mitchener 1975a Tardiff et al. 1980). 

Cardiovascular Effects. No gross or histological alterations in the heart or changes in heart weight were observed in rats treated dermally with doses of 50-250 mg 4- nitrophenol/kg/day for 120 days (Angerhofer 1985). 

In experimental animals, the cardiovascular system does not appear to be a target for acrolein. Nonspecific inflammatory lesions in the heart were reported in rats, dogs, monkeys, and guinea pigs after intermediate-duration exposure to similar concentrations of acrolein (Lyon et al. 1970). Also, an increase in relative heart weight was observed in hamsters and rats exposed to 4.9 ppm of acrolein (Feron et al. 1978). 

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