Peptide biochemical degradation

Elliott DF. Specific chemical methods for the fission of peptide bonds. I. /V-acyl to O-acyl transformation in the degradation of silk fibroin. Biochem J 542, 1952. 

An eloquent example of the biochemical complexity of peptide degradation in blood is afforded by dynorphin A-( 1-13) (Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys), a potent opioid peptide. When incubated at 37° with human plasma, dynorphin A-(l -13) had a tm value of < 1 min, and... 

I. F. Benter, E. M. Hirsh, A. J. Tuchman, P. E. Ward, N-Terminal Degradation of Low Molecular Weight Opioid Peptides in Human Cerebrospinal Fluid , Biochem. Pharmacol. 1990, 40, 465-472. 

The biochemical processes accompanying maturation appear to begin early in the development of the enamel at a time when the organic matrix and its protein constituents are immature. If consists of the selective loss and the selective retention of certain components from the enamel suggesting protein and/or peptide degradation or depolymerization. 

A number of approaches have been used to prove that a suspected transmitter resides in the presynaptic terminal of the pathway under study. These include biochemical analysis of regional concentrations of suspected transmitters, often combined with interruption of specific pathways, and microcytochemical techniques. Immunocytochemical techniques have proved very useful in localizing peptides and enzymes that synthesize or degrade nonpeptide transmitters. 

John H, Huynh KD, Hedtmann C, Walden M, Schulz A, Anspach FB, Forssmann WG (2005) In vitro degradation of the antimicrobial human peptide HEM-y 130-146 in plasma analyzed by a validated quantitative LC-MS/MS procedure. Anal Biochem 341 173-186... 

Horsthemke B, Bauer K (1982) Substrate specificity of an adenohypophyseal endopeptidase capable of hydrolyzing LHRH preferential cleavage of peptide bonds involving the carboxyl terminus of lower of it of hydrophobic and basic amino acids. Biochemistry 21 1033-1036 Horsthemke B, Knisataschek H, Rivier J, Sandow J, Bauer K (1981) Degradation of LHRH and analogs by adenohypophyseal peptidases. Biochem biophys Res Commun 100 753-759... 

Nam ST, Kim DH, Lee MB, Nam HJ, Kang JK, Park MJ et al (2013) Insect peptide CopA3-induced protein degradation of p27Kipl stimulates proliferation and protects neuronal cells from apoptosis. Biochem Biophys Res Commun 437 35-40... 

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