Pentoxifylline Theophylline

C7HsN402 83-67-0) see Pentifylline Protheobromine theobromine sodium salt (C7H7N4Na02 1010-59-9) sec Pentoxifylline theophylline... 

Pentoxifylline is stmcturaHy related to other methylxanthine derivatives such as caffeine [58-02-2] (1,3,7-trimethylxanthine), theobromine [83-67-0] (3,7-dimethylxanthine), and theophylline [58-55-9] (3,7-dihydro-1,3-dimethyl-1 H-piirine-2,6-dione or 1,3-dimethylxanthine), which also show radioprotective activity in some instances, suggesting that methylxanthines as a dmg class may radioprotect through a common mechanism (see Alkaloids). In a retrospective analysis of cervical and endometrial cancer patients receiving primary or adjuvant XRT, no association between caffeine consumption and incidence of acute radiation effects has been found. However, there was a decreased incidence of severe late radiation injury in cervical cancer patients who consumed higher levels of caffeine at the time of thek XRT (121). The observed lack of correlation between caffeine consumption and acute radiation effects is consistent with laboratory investigations using pentoxifylline. 

Bromoethyl)theophylline Pimefylline nicotinate 2-Bromo- -fluoro-17a 1 -dihydroxy-9/3,11/3-oxido-pregna-1,4-diene-3,20-dione-17,21 -acetate Halopredone acetate 1 -Bromo-5-hexanone Pentoxifylline... 

CNS stimulants can be classified as Psychomotor stimulants compounds that display a stimulatory effect primarily on brain functions and which activate mental and physical activity of the organism. They are made up of methylxanthines (caffeine, theophylline, pentoxifyllin), amphetamines (dextroamphetamine, methamphetamine), and also methylphenidate and pemoline. Respiratory stimulants or analeptics compounds, which cause certain activations of mental and physical activity of the organism, and primarily excite the vasomotor and respiratory centers of the medulla (doxapram, almitrine).Drwgi that suppress appetite or anorectics drags that activate mental and physical activity of the organism, but primarily accentuate the excitatory center of satiation in the hypothalamus (phentermine, diethylpropion).In order to increase mental capability, nootropics — drugs that increase the functional state of the brain — are sometimes used, the effect of which is associated with blood flow and metabolism of the brain. 

Oral equivalent to 64, 127, 254, 382 mg theophylline tablets 32, 64 mg/5 mL syrup Pentoxifylline (generic, Trental)... 

PENTOXIFYLLINE BRONCHODILATORS- THEOPHYLLINE Possibly t theophylline levels Uncertain possibly competitive inhibition of theophylline metabolism (pentoxifylline is also a xanthine derivative) Warn patients of the possibility of adverse effects of theophylline monitor levels if necessaiy... 

The xanthines used in nnedicine are quite a homogenous group as regards UV spectra. All the compounds listed (caffeine [002], pentoxifylline [006], diprophylline [1406], etofylline [1407], theobromine [1414], theophylline [1415]) have a good, constant absorption band at 272 2 nm e approximately 9000-10000 in methanol minimum 242 2 nm (see figure 10). 

The drug pentoxifylline, a 2-hexanoyl analog of such xanthines as theophylline and caffeine, has the ability to lower blood viscosity by increasing the flexibility of red blood cell membranes in patients. This is most probably due to PDE inhibition, which increases c-AMP levels. Unlike the vasodilators considered earlier, pentoxifylline is effective in claudication. 

The methylxanthines consist of aminophylline, dyphylline, enprofylline, and pentoxifylline. Aminophylline is the most widely used of the soluble theophyllines. 

The methylxanthines consist of aminophylline, dyphyl-line, enprofylline, and pentoxifylline. Aminophylline (theophylline ethylenediamine) is the most widely used of the soluble theophyllines. Its main therapeutic effect is bronchodilation. In addition, it causes CNS stimulation, cardiac acceleration, diuresis, and gastric secretion. Aminophylline is available in an oral, rectal (pediatric), or intravenous solution, which is used in the treatment of status asthmaticus. Although it is a less effective bronchodilator than beta-adrenergic agonists, it is particularly useful in preventing nocturnal asthma (see also Figure 94). 

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