Theophylline tablets

The rapid and non-destructive analysis features of NIR make it an ideal method to investigate film-coated tablets. Kirsch and Drennen101 analyzed theophylline tablets... 

While particle size continues to be the physical property most frequently determined by NIR spectroscopy, several other parameters including the dissolution rate and the thickness and hardness of the ethylcellulose coating on theophylline tablets have also been determined using NIR, all with good errors of prediction.94 Tablet hardness, which dictates mechanical stability and dissolution rate, has been determined in hydrochlorothiazide tablets.95... 

Oral equivalent to 64, 127, 254, 382 mg theophylline tablets 32, 64 mg/5 mL syrup Pentoxifylline (generic, Trental)... 

Q. Xun Dang, L. Xia Yan, Z.-Pei Sun, and D.-Kui Ling, Separation and simultaneous determination of the active ingredients in theophylline tablets by micellar electrokinetic capillary chromatography, J. Chromatogr., 630 363 (1993). 

Theophylline tablets made by both direct compression and wet granulation have been assessed. There is almost no difference between direct compression and wet granulation methods (see Figures 12-14) under the following conditions appropriate formulation (sufficient level of HPMC in the tablet) and precise control of the wet granulation process. Direct compression using Metolose SR is recognized as a suitable process for matrix tablets. 

Rodriguez, L., Cini, M., Cavallari, C., Passerini, N., Fabrizio Saettone, M., Fini, A., and Caputo, O. (1998), Evaluation of theophylline tablets compacted by means of novel ultrasound-assisted apparatus, Int. J. Pharm., 170, 201-208. 

Zhang, F. McGinity, J.W. Properties of hot-melt extruded theophylline tablets containing poly (vinyl acetate). Drug Dev. Ind. Pharm. 2000, 29 (6), 938-948. 

Phadnis, N.V. Suryanarayanan, R. Polymorphism in anhydrous theophylhne-implications for the dissolution rate of theophylline tablets. J. Pharm. Sci. 1997, 86 (11), 1256-1263. 

Caneron CG, McGinity JW. Controlled-release theophylline tablet formulations containing acrylic resins, part 3 influence of filler excipient. Drug Dev Ind Pharm 1987 13(2) 303-318. 

In one paper by Kirsch and Drennen [62], three experiments were performed on coated tablets. In the first experiment, intact theophylline tablets coated with an ethylcellulose polymer were analyzed by acousto-optic tunable filter (AOTF) spectrometers. Tablets were coated with increasing levels of ethylcellulose to vary the dissolution profiles. After spectra were collected, the dissolutions were run on a U.S.P. Type II dissolution apparatus. The time required for 50% of the drug to enter solution was used as the measure of dissolution rate. Principal component (PC) regression was used to develop the calibration. This gave a SEE of 2.8 min, a coefficient of variation of 0.977, and a SEP of 6.6 min the time to 50% dissolution ranged from 48 to 93 min. 

A dosage interval of 12 h appears to be appropriate to use in dogs for oral sustained-release anhydrous theophylline tablets (Koritz et al, 1986) and oral sustained-release morphine sulphate tablets (Dohoo et al, 1994). Following oral administration of these sustained-release dosage forms, the average systemic availability of theophylline is 76% and of morphine is 21%. Gastro-... 

Choline Theophyllinate Tablets (100 mg) Chymotrypsine Tablets (27 mg) Cimetidine Tablets (200 mg) Cimetidine Tablets (280 mg) Cimetidine Tablets (400 mg) Clenbuterol Tablets (20 pg)... 

Ethambutol Tablets (400 mg), DC Ethambutol Tablets (400 mg), WG Ethambutol Tablets (800 mg) Etophylline + Theophylline Tablets... 

Goldenheim PD, Conrad EA, Schein LK. Treatment of asthma by a controlled-release theophylline tablet formulation a review of the North American experience with nocturnal dosing. Chronobiol Int 1987 4(3) 397-408. 

Table 26 Benchmarking between HPLC and HPTLC for assay of theophylline tablets...

E. Sanchez, C. M. Evora, and M. Llabres, Effect of humidity and packaging on the long-term aging of commercial sustained-release theophylline tablets, Int. J. Pharm. 83, 59-63 (1992). 

A patient with chronic obstructive pulmonary disease had a 53% reduction in his serum theophylline levels accompanied by bronchospasm when he was fed continuously through a nasogastric tube with OsmoUte. The interaction occurred with both theophylline tablets (Theo-Dur) and liquid theophylline, but not when the theophylline was given intravenously as aminophylline. It was also found that the interaction could be avoided by interrupting feeding 1 hour either side of the oral liquid theophylline dose. Conversely, hourly administration of 100 mL of OsmoUte did not affect the extent of theophylline absorption from a slow-release preparation Slo-bid Gyrocaps) in healthy subjects, although the rate of absorption was slowed. Similarly, in healthy subjects, hourly administration of 100 mL of Ensure for 10 hours did not affect the rate or extent of absorption of theophylline from Theo-24 tablets. ... 

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